3-METHYL-2-PYRROLIDINONE
- Product Name
- 3-METHYL-2-PYRROLIDINONE
- CAS No.
- 2555-05-7
- Chemical Name
- 3-METHYL-2-PYRROLIDINONE
- Synonyms
- 3-methylpyrrolidin-2-one;α-Methylbutyrolactam;3-Methyl-2-pyrrolidone;3-METHYL-2-PYRROLIDINONE;alpha-Methylbutyrolactame;2-Pyrrolidinone,3-methyl-;(R,S)-3-Methyl-pyrrolidin-2-one;alpha-Methylbutyrolactam~3-Methyl-2-pyrrolidone
- CBNumber
- CB8756738
- Molecular Formula
- C5H9NO
- Formula Weight
- 99.13
- MOL File
- 2555-05-7.mol
3-METHYL-2-PYRROLIDINONE Property
- Melting point:
- 55°C
- Boiling point:
- 118-120 °C(Press: 10 Torr)
- Density
- 0.979±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 16.66±0.40(Predicted)
- Appearance
- White to off-white Solid
Safety
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- Y8455
- Product name
- 3-Methylpyrrolidin-2-one
- Packaging
- 100mg
- Price
- $109
- Updated
- 2021/12/16
- Product number
- 085718
- Product name
- 3-Methylpyrrolidin-2-one
- Purity
- 97%
- Packaging
- 1g
- Price
- $249
- Updated
- 2021/12/16
- Product number
- Y8455
- Product name
- 3-Methylpyrrolidin-2-one
- Packaging
- 10g
- Price
- $1432
- Updated
- 2021/12/16
- Product number
- 085718
- Product name
- 3-Methylpyrrolidin-2-one
- Purity
- 97%
- Packaging
- 10g
- Price
- $1932
- Updated
- 2021/12/16
- Product number
- A180761
- Product name
- 3-Methylpyrrolidin-2-one
- Purity
- 97%
- Packaging
- 100mg
- Price
- $37
- Updated
- 2021/12/16
3-METHYL-2-PYRROLIDINONE Chemical Properties,Usage,Production
Synthesis Reference(s)
Tetrahedron, 43, p. 1811, 1987 DOI: 10.1016/S0040-4020(01)81492-7
Synthesis
108303-99-7
2555-05-7
1-Benzyl-3-methylpyrrolidin-2-one (0.323 g, 1.7 mmol, 1.0 eq.) was used as a starting material and dissolved in toluene (2 mL, 1 M). Trifluoromethanesulfonic acid (0.604 mL, 6.8 mmol, 4.0 eq.) was added to this solution. The reaction mixture was placed in a microwave reactor and heated at 195°C for 25 minutes. Upon completion of the reaction, the mixture was poured into a small amount of saturated aqueous sodium bicarbonate solution for neutralization. The aqueous phase was extracted with ethyl acetate and the organic phase was again washed with saturated aqueous sodium chloride solution. The combined aqueous phases were again extracted with ethyl acetate. All organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated in vacuum. The crude product was purified by silica gel column chromatography with a gradient of dichloromethane solution of 0-10% methanol as eluent to give 3-methyl-2-pyrrolidinone (0.087 g). The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 6.49 (br s, 1H), 3.37-3.26 (m, 2H), 2.53-2.28 (m, 2H), 1.80-1.65 (m, 1H), 1.21-1.19 (d, 3H, J = 6.6 Hz).
References
[1] Patent: US2015/284362, 2015, A1. Location in patent: Paragraph 0299
[2] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 3, p. 293 - 297
3-METHYL-2-PYRROLIDINONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-METHYL-2-PYRROLIDINONE manufacturers
- Product
- 3-Methyl-2-pyrrolidinon 2555-05-7
- Price
- US $0.00/KG
- Min. Order
- 0.0001KG
- Purity
- 98%min
- Supply Ability
- 100kgs/month
- Release date
- 2022-05-10