ChemicalBook > CAS DataBase List > 3-METHYL-2-PYRROLIDINONE

3-METHYL-2-PYRROLIDINONE

Product Name
3-METHYL-2-PYRROLIDINONE
CAS No.
2555-05-7
Chemical Name
3-METHYL-2-PYRROLIDINONE
Synonyms
3-methylpyrrolidin-2-one;α-Methylbutyrolactam;3-Methyl-2-pyrrolidone;3-METHYL-2-PYRROLIDINONE;alpha-Methylbutyrolactame;2-Pyrrolidinone,3-methyl-;(R,S)-3-Methyl-pyrrolidin-2-one;alpha-Methylbutyrolactam~3-Methyl-2-pyrrolidone
CBNumber
CB8756738
Molecular Formula
C5H9NO
Formula Weight
99.13
MOL File
2555-05-7.mol
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3-METHYL-2-PYRROLIDINONE Property

Melting point:
55°C
Boiling point:
118-120 °C(Press: 10 Torr)
Density 
0.979±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
16.66±0.40(Predicted)
Appearance
White to off-white Solid
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific
Product number
Y8455
Product name
3-Methylpyrrolidin-2-one
Packaging
100mg
Price
$109
Updated
2021/12/16
Matrix Scientific
Product number
085718
Product name
3-Methylpyrrolidin-2-one
Purity
97%
Packaging
1g
Price
$249
Updated
2021/12/16
AK Scientific
Product number
Y8455
Product name
3-Methylpyrrolidin-2-one
Packaging
10g
Price
$1432
Updated
2021/12/16
Matrix Scientific
Product number
085718
Product name
3-Methylpyrrolidin-2-one
Purity
97%
Packaging
10g
Price
$1932
Updated
2021/12/16
CHESS
Product number
3564
Product name
3-Methyl-pyrrolidin-2-one
Purity
98
Packaging
1g
Price
$12000
Updated
2021/12/16
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3-METHYL-2-PYRROLIDINONE Chemical Properties,Usage,Production

Synthesis Reference(s)

Tetrahedron, 43, p. 1811, 1987 DOI: 10.1016/S0040-4020(01)81492-7

Synthesis

108303-99-7

2555-05-7

1-Benzyl-3-methylpyrrolidin-2-one (0.323 g, 1.7 mmol, 1.0 eq.) was used as a starting material and dissolved in toluene (2 mL, 1 M). Trifluoromethanesulfonic acid (0.604 mL, 6.8 mmol, 4.0 eq.) was added to this solution. The reaction mixture was placed in a microwave reactor and heated at 195°C for 25 minutes. Upon completion of the reaction, the mixture was poured into a small amount of saturated aqueous sodium bicarbonate solution for neutralization. The aqueous phase was extracted with ethyl acetate and the organic phase was again washed with saturated aqueous sodium chloride solution. The combined aqueous phases were again extracted with ethyl acetate. All organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated in vacuum. The crude product was purified by silica gel column chromatography with a gradient of dichloromethane solution of 0-10% methanol as eluent to give 3-methyl-2-pyrrolidinone (0.087 g). The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 6.49 (br s, 1H), 3.37-3.26 (m, 2H), 2.53-2.28 (m, 2H), 1.80-1.65 (m, 1H), 1.21-1.19 (d, 3H, J = 6.6 Hz).

References

[1] Patent: US2015/284362, 2015, A1. Location in patent: Paragraph 0299
[2] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 3, p. 293 - 297

3-METHYL-2-PYRROLIDINONE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-METHYL-2-PYRROLIDINONE manufacturers

Shanghai Rlavie Technology Co ltd
Product
3-Methyl-2-pyrrolidinon 2555-05-7
Price
US $0.00/KG
Min. Order
0.0001KG
Purity
98%min
Supply Ability
100kgs/month
Release date
2022-05-10

2555-05-7, 3-METHYL-2-PYRROLIDINONERelated Search:

CAPTAFOL DIHYDROCYTOCHALASIN B CYTOCHALASIN E CYTOCHALASIN C 1-methyl-3-pyrrolidinone ALPHA-METHYL-ALPHA-PROPYLSUCCINIMIDE CYTOCHALASIN A 1,2-Cyclohexanedicarboximide Cytochalasin H CIS-1,2,3,6-TETRAHYDROPHTHALIMIDE 3-METHYL-2-PYRROLIDINONE N-Methyl-2-pyrrolidone L-Pyroglutaminol (S)-(+)-5-(Hydroxymethyl)-2-pyrrolidinone p-toluenesulfonate 1-METHYL-3-TRIFLUOROMETHYL-2-PYRAZOLIN-5-ONE 5-METHYL-2-PYRROLIDINONE 4-methyl-2-Pyrrolidinone 3-AMINO-2,2,5,5-TETRAMETHYL-1-PYRROLIDINYLOXY

  • (R,S)-3-Methyl-pyrrolidin-2-one
  • 2-Pyrrolidinone,3-methyl-
  • 3-methylpyrrolidin-2-one
  • α-Methylbutyrolactam
  • 3-METHYL-2-PYRROLIDINONE
  • alpha-Methylbutyrolactam~3-Methyl-2-pyrrolidone
  • alpha-Methylbutyrolactame
  • 3-Methyl-2-pyrrolidone
  • 2555-05-7
  • Pyrrolidines