NEUROPEPTIDE Y (HUMAN, RAT)

NEUROPEPTIDE Y (HUMAN, RAT) Property

storage temp. 

-15°C

Sequence

Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr

Hazard and Precautionary Statements (GHS)

NEUROPEPTIDE Y (HUMAN, RAT) Chemical Properties,Usage,Production

Uses

Neuropeptide Y (human) free acid is the deamidated form of Neuropeptide Y (human, rat, mouse) (HY-P0198). The amidation of Neuropeptide Y C-terminal tyrosine is critical for its function. Non-amidated Neuropeptide Y fails to elicit G protein signaling[1][2][4].

References

[1] Cajado et al. Neuropeptide Y family-degrading metallopeptidases in the Tityus serrulatus venom partially blocked by commercial antivenoms. Toxicol Sci. 2014 Dec;142(2):418-26. DOI:10.1093/toxsci/kfu193
[2] Sung CP, et al. Neuropeptide Y upregulates the adhesiveness of human endothelial cells for leukocytes. Circ Res. 1991 Jan;68(1):314-8. DOI:10.1161/01.res.68.1.314
[3] Gordon EA, et al. Characterization of functional neuropeptide Y receptors in a human neuroblastoma cell line. J Neurochem. 1990 Aug;55(2):506-13. DOI:10.1111/j.1471-4159.1990.tb04164.x
[4] Chaehee Park, et al. Structural basis of neuropeptide Y signaling through Y1 receptor. Nat Commun. 2022 Feb 14;13(1):853. DOI:10.1038/s41467-022-28510-6