2-Formylfuran-5-boronic acid

Product Name: 2-Formylfuran-5-boronic acid
CAS No.: 27329-70-0
Chemical Name: 2-Formylfuran-5-boronic acid
Synonyms: 5-FORMYL-2-FURYLBORONIC ACID;5-Formylfuran-2-ylboronic acid;FFBA;AKOS BRN-0038;CHEMBRDG-BB 3200975;TIMTEC-BB SBB004171;RARECHEM AH PB 0213;5-Borono-2-furaldehyde;5-FORMYL-THIOBORONICACID;Lapanitinib Intermediate 4
CBNumber: CB8766094
Molecular Formula: C5H5BO4
Formula Weight: 139.9
MOL File: 27329-70-0.mol

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2-Formylfuran-5-boronic acid Property

Melting point:: 136 °C (dec.) (lit.)
Boiling point:: 379.3±52.0 °C(Predicted)
Density: 1.36±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: 1.38g/l
pka: 7.11±0.53(Predicted)
form: powder
color: brown
Water Solubility: Insoluble in water.
Sensitive: Air Sensitive
BRN: 1637050
InChI: InChI=1S/C5H5BO4/c7-3-4-1-2-5(10-4)6(8)9/h1-3,8-9H
InChIKey: JUWYQISLQJRRNT-UHFFFAOYSA-N
SMILES: B(C1=CC=C(C=O)O1)(O)O
CAS DataBase Reference: 27329-70-0(CAS DataBase Reference)

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Safety

Hazard Codes: C,Xi
Risk Statements: 34-36/37/38
Safety Statements: 26-36/37/39-45-37/39-27
RIDADR: UN 3261 8/PG 3
WGK Germany: 3
Hazard Note: Irritant
TSCA: No
HazardClass: IRRITANT, KEEP COLD
PackingGroup: Ⅲ
HS Code: 29321900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 512346
Product name: 5-Formyl-2-furanylboronic acid
Purity: ≥95%
Packaging: 5g
Price: $144
Updated: 2025/07/31

Sigma-Aldrich

Product number: 512346
Product name: 5-Formyl-2-furanylboronic acid
Purity: ≥95%
Packaging: 1g
Price: $28.4
Updated: 2023/06/20

TCI Chemical

Product number: F0611
Product name: 5-Formyl-2-furanboronic Acid (contains varying amounts of Anhydride)
Packaging: 1g
Price: $20
Updated: 2025/07/31

TCI Chemical

Product number: F0611
Product name: 5-Formyl-2-furanboronic Acid (contains varying amounts of Anhydride)
Packaging: 5g
Price: $47
Updated: 2025/07/31

TRC

Product number: F700345
Product name: (5-Formylfuran-2-yl)boronicAcid
Packaging: 25g
Price: $175
Updated: 2021/12/16

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2-Formylfuran-5-boronic acid Chemical Properties,Usage,Production

Chemical Properties

beige to brown powder

Uses

suzuki reaction

Uses

As a bifunctional reagent used in the synthesis of π -extended heteroarylfuran systems. Reactant involved in Suzuki coupling for synthesis of stable dye-sensitized solar cells. Reactant involved in synthesis of biologically active molecules including, heteroarylation for the synthesis of HIF-1 inhibitors, disalicylic acid-furanyl derivatives to inhibit ephrin binding, HIV-1 integrase inhibitors, epidermal growth factor receptor inhibitors.

Synthesis

13529-27-6

27329-70-0

Under nitrogen protection, 20.16 g (0.118 mol) of 2-(diethoxymethyl)furan, 33.4 g (0.177 mol) of triisopropyl borate, and 40 mL of anhydrous tetrahydrofuran (THF) were added to a dry 500 mL three-necked flask equipped with a mechanical stirrer, an internal thermometer, and a dosing funnel. The water content of the reaction mixture was determined by Karl-Fischer titration to ensure that it was less than 800 μg/mL. the reaction mixture was cooled to an internal temperature of -10 °C. The reaction mixture was then purified to a temperature of -10 °C. The water content of the reaction mixture was determined by titration. With the temperature maintained at -10 °C to 0 °C, 84 mL (25 wt%, 1.84 M THF solution containing heptane and ethylbenzene from Chemmetal, content determined by titration, 1.3 equivalents) of LDA solution was slowly added through the addition funnel over a period of 1 hour. Upon completion of addition, the reaction mixture was transferred via cannula to a pre-cooled aqueous hydrochloric acid solution (prepared by mixing 33 mL of concentrated hydrochloric acid and 55 mL of water). The reaction temperature was controlled not to exceed 30 °C. The resulting tan slurry of 5-formylfuran-2-boronic acid was cooled to 0°C and filtered. The filter cake was washed twice with 20 mL of cold water to obtain 17.6 g of wet filter cake. The wet filter cake was dried in a vacuum oven at 40 °C to give 12.41 g of an off-white product, 5-formylfuran-2-boronic acid, in a total yield of 75%. The amount of unreacted furfural in the crude product was determined to be less than 0.1% by analysis.

References

[1] Patent: EP1403271, 2004, A1. Location in patent: Page 3, 4
[2] Organic and Biomolecular Chemistry, 2003, vol. 1, # 9, p. 1447 - 1449

2-Formylfuran-5-boronic acid Preparation Products And Raw materials

Raw materials

Triethyl orthoformate Ammonium chloride Triisopropyl borate Furfural n-Butyllithium

Preparation Products

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2-Formylfuran-5-boronic acid Suppliers

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View Lastest Price from 2-Formylfuran-5-boronic acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2-Formylfuran-5-boronic acid 27329-70-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-09

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: 2-Formylfuran-5-boronic acid 27329-70-0
Price: US $999.00-666.00/ton
Min. Order: 1ton
Purity: 99%
Supply Ability: 5000
Release date: 2024-08-13

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Formylfuran-5-boronic acid 27329-70-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

27329-70-0, 2-Formylfuran-5-boronic acidRelated Search:

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5-Formylfuran-2-boronicacid,97%

5-FORMYL-THIOBORONICACID

2-FORMAYLFURAN-5-BORONIC ACID

5-Formyl-2-furanboronic Acid (contains varying amounts of Anhydride)

(5-formyl-2-furanyl)Boronic

5-Formylfuran-2-ylboronic acid

5-Formylfuran-2-boronic acid ,98%

5-Formyl-2-furanylboronic acid,5-Formyl-2-furanboronic acid

(5-formyl-2-furyl)boronic acid(SALTDATA: FREE)

2-Formylfuran-5-boronic acid,90%,tech.

2-Formylfuran-5-boronic acid,99%

2-ForMylfuran-5-boronic acid ,97%

Boronic acid, B-(5-forMyl-2-furanyl)-

2-ForMyl-5-furanboronicacid

5 - base furan forMaldehyde - 2 - boric acid

5-ForMyl-2-Furyl Boronic Acid(FFBA)

2-Formylfuran-5-boronic acid 5-Formyl-2-furylboronic acid

Lapanitinib Intermediate 4

5-Formyfuran-2-boronic acid

5-formylfurane-2-boronic acid

5-Formylfuran-2-boronic acid, 95%, for synthesis

2-Formylfuran-5-boronic acid5-

(5-formylfuran-2-yl)boronicaci

5-Formaldehyde-furan-2-boric acid

B-(5-Formyl-2-furanyl)boronic acid

5-Formylfuran-2-boronic acid 98%

2-Formylfuran-5-boronic acid - [F3420]

(2-Formylfuran-5-yl)boronic acid

B-(5-Formyl-furan-2-yl)boronic acid

27329-70-0

27239-70-0

C5H5BO4

BORONIC ACID

Organometallic Reagents

Heteroaryl

Boronic Acids and Derivatives

Boronic Acids

Pyrans

Lapatinib