Nafcillin sodium salt monohydrate
- Product Name
- Nafcillin sodium salt monohydrate
- CAS No.
- 7177-50-6
- Chemical Name
- Nafcillin sodium salt monohydrate
- Synonyms
- nafcillin sodium;Nafcillin sodium hydrate;Nafcillin sodium monohydrate;D00928;CL 8491;Unipen (tn);Naproxillin sodium;Emorfazone Impurity 1;Nafcillin sodium (usp);NAFCILLINSODIUMSTERILE
- CBNumber
- CB8769646
- Molecular Formula
- C21H25N2NaO6S
- Formula Weight
- 456.49
- MOL File
- 7177-50-6.mol
Nafcillin sodium salt monohydrate Property
- storage temp.
- 2-8°C
- solubility
- H2O: soluble50mg/mL
- form
- A crystalline solid
- color
- White to off-white
- CAS DataBase Reference
- 7177-50-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-42/43
- Safety Statements
- 26-36-24/25
- WGK Germany
- 3
- HS Code
- 29411099
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284Wear respiratory protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- N3269
- Product name
- Nafcillin sodium salt monohydrate
- Packaging
- 5g
- Price
- $191
- Updated
- 2024/03/01
- Product number
- 1450007
- Product name
- Nafcillin sodium
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- 21008
- Product name
- Nafcillin (sodium salt hydrate)
- Purity
- ≥95%
- Packaging
- 1g
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 21008
- Product name
- Nafcillin (sodium salt hydrate)
- Purity
- ≥95%
- Packaging
- 5g
- Price
- $152
- Updated
- 2024/03/01
- Product number
- PHR1704
- Product name
- Nafcillin Sodium
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 1g
- Price
- $137
- Updated
- 2022/05/15
Nafcillin sodium salt monohydrate Chemical Properties,Usage,Production
Originator
Unipen,Wyeth,US,1964
Uses
Sodium Nafcillin Monohydrate is used as an antibiotic, used in the treatment, used in the treatment of gram-positive bacteria.
Uses
Antibacterial;Bacterial transpeptidase inhibitor
Uses
Nafcillin sodium salt monohydrate is an antibiotic resistant to beta-lactamase.
Definition
ChEBI: Nafcillin sodium monohydrate is an organic sodium salt and a hydrate. It contains a nafcillin sodium.
Manufacturing Process
A stirred suspension of 12.6 grams 6-aminopenicillanic acid in 130 ml dry alcohol-free chloroform was treated with 16 ml triethylamine and then with 13.8 grams of a solution of 2-ethoxy-1-naphthoyl chloride in 95 ml chloroform. After being washed successively with 58 ml each of 1 N and then 0.1 N hydrochloric acid the chloroform solution was extracted with N aqueous sodium bicarbonate (58 ml + 6 ml). The combined bicarbonate extracts were washed with 20 ml ether and then evaporated at low temperature and pressure to give the crude sodium salt of 2-ethoxy-1-naphthylpenicillin [also called sodium 6-(2-ethoxy-1-naphthamido)penicillinate] as a yellow powder (20.3 grams). This was dissolved in 20 ml water at 30°C and diluted with 180 ml n-butanol, also at 30°C, with stirring. Slow cooling to 0°C gave colorless needles of the product.
brand name
Nallpen (GlaxoSmithKline).
Therapeutic Function
Antibacterial
Clinical Use
Nafcillin sodium, 6-(2-ethoxy-1-naphthyl)penicillin sodium(Unipen), is another semisynthetic penicillin that resultedfrom the search for penicillinase-resistant compounds. Likemethicillin, nafcillin has substituents in positions ortho tothe point of attachment of the aromatic ring to the carboxamidegroup of penicillin. No doubt, the ethoxy group andthe second ring of the naphthalene group play steric roles instabilizing nafcillin against penicillinase. Very similar structureshave been reported to produce similar results in somesubstituted 2-biphenylpenicillins.
Unlike methicillin, nafcillin is stable enough in acid topermit its use by oral administration. When it is givenorally, its absorption is somewhat slow and incomplete,but satisfactory plasma levels may be achieved in about1 hour. Relatively small amounts are excreted throughthe kidneys; most is excreted in the bile. Even thoughsome cyclic reabsorption from the gut may occur, nafcillingiven orally should be readministered every 4 to 6 hours.This salt is readily soluble in water and may be administeredintramuscularly or intravenously to obtain highplasma concentrations quickly for the treatment of seriousinfections.
Nafcillin sodium may be used in infections causedsolely by penicillin G-resistant staphylococci or whenstreptococci are present also. Although it is recommendedthat it be used exclusively for such resistant infections, nafcillin is also effective against pneumococci and groupA -hemolytic streptococci. Because, like other penicillins,it may cause allergic side effects, it should be administeredwith care.
Nafcillin sodium salt monohydrate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Nafcillin sodium salt monohydrate manufacturers
- Product
- Nafcillin sodium salt monohydrate 7177-50-6
- Price
- US $0.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2021-04-25
- Product
- Nafcillin sodium salt monohydrate 7177-50-6
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-08-07