ChemicalBook > CAS DataBase List > 1-Hydroxybenzotriazole hydrate

1-Hydroxybenzotriazole hydrate

Product Name: 1-Hydroxybenzotriazole hydrate
CAS No.: 123333-53-9
Chemical Name: 1-Hydroxybenzotriazole hydrate
Synonyms: 1-HYDROXYBENZOTRIAZOLE MONOHYDRATE;HOBT H2O;HOBT HYDRATE;HOBT.H20;1H-benzo[d][1,2,3]triazol-1-ol hydrate;N-HYDROXYBENZOTRIAZOLE HYDRATE;HOBTM;e hydrate;CAS:123333-53-9;HOBT MONOHYDRATE
CBNumber: CB8775919
Molecular Formula: C6H7N3O2
Formula Weight: 153.14
MOL File: 123333-53-9.mol

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1-Hydroxybenzotriazole hydrate Property

Melting point:: 155-158 °C(lit.)
Boiling point:: 248.8°C (rough estimate)
Density: 1.065 g/cm
refractive index: 1.6910 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMF: 100 mg/mL, clear
form: Solid
color: White to Off-White
Water Solubility: slightly soluble
BRN: 4515
Stability:: Hygroscopic
InChI: InChI=1S/C6H5N3O.H2O/c10-9-6-4-2-1-3-5(6)7-8-9;/h1-4,10H;1H2
InChIKey: PJUPKRYGDFTMTM-UHFFFAOYSA-N
SMILES: ON1N=NC2C=CC=CC1=2.O
CAS DataBase Reference: 123333-53-9(CAS DataBase Reference)

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Safety

Hazard Codes: F
Risk Statements: 5-11-R5-R11-44-1
Safety Statements: 15-16-35-7/9-33-S7/9-S33-S16-60-37-26
RIDADR: UN 3380 4.1/PG 1
WGK Germany: -
F: 4.10-8
Hazard Note: Highly Flammable
HazardClass: 4.1
HS Code: 29339980

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H319Causes serious eye irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P230Keep wetted with …

P233Keep container tightly closed.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P380+P375in case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 157260
Product name: 1-Hydroxybenzotriazole hydrate
Purity: wetted with not less than 14 wt. % water, 97%
Packaging: 25g
Price: $83.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: 157260
Product name: 1-Hydroxybenzotriazole hydrate
Purity: wetted with not less than 14 wt. % water, 97%
Packaging: 100g
Price: $187.15
Updated: 2025/07/31

Sigma-Aldrich

Product number: 711489
Product name: 1-Hydroxybenzotriazole hydrate
Purity: wetted with not less than 20 wt. % water, 97%
Packaging: 50g
Price: $137
Updated: 2025/07/31

Sigma-Aldrich

Product number: 711489
Product name: 1-Hydroxybenzotriazole hydrate
Purity: wetted with not less than 20 wt. % water, 97%
Packaging: 250g
Price: $464
Updated: 2025/07/31

Sigma-Aldrich

Product number: 711489
Product name: 1-Hydroxybenzotriazole hydrate
Purity: wetted with not less than 20 wt. % water, 97%
Packaging: 1kg
Price: $1440
Updated: 2025/07/31

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1-Hydroxybenzotriazole hydrate Chemical Properties,Usage,Production

Chemical Properties

White to off-white powder

Uses

1-Hydroxybenzotriazole hydrate can be used as a condensation reagent to prepare:

Poly-γ-glutamic acid methyl ester from a dimer of γ-glutamic acid.
Oxadiazoles via cyclo condensation of amidoximes with trifluoroacetic anhydride or benzoic acid derivatives.

Uses

A common additive for peptide coupling.

Uses

1-Hydroxybenzotriazole hydrate is used as an additive for oligonucleotide couplings and in racemization-free peptide couplings.

General Description

1-Hydroxybenzotriazole is a coupling reagent used to synthesize amides by the condensation reaction between the activated ester/acid and the amino group of protected amino acids. It is also used as a racemization suppressor during peptide synthesis.

reaction suitability

reaction type: Addition Reactions

Toxics Screening Level

The ITSL 1-Hydroxy benzotriazole has been changed from 0.04 μg/m3 to 0.1 μg/m3 based on an annual averaging time.

1-Hydroxybenzotriazole hydrate Preparation Products And Raw materials

Raw materials

4-Methylmorpholine

Preparation Products

Cefodizime

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View Lastest Price from 1-Hydroxybenzotriazole hydrate manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 1-Hydroxybenzotriazole hydrate 123333-53-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20T
Release date: 2025-08-30

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 1-Hydroxybenzotriazole hydrate 123333-53-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-03

Hebei Chuanghai Biotechnology Co., Ltd

Product: 1-Hydroxybenzotriazole hydrate 123333-53-9
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-23

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HOBt hydrate (<5 ppm hydrazine)

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N-HYDROXYBENZOTRIAZOLE MONOHYDRATE

N-HYDROXYBENZOTRIAZOLE HYDRATE

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TIMTEC-BB SBB000114

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1-HYDROXY BENZOTRIAZOLE MONOHYDATE

HOBt(hydrate) N-Hydroxybenzotnazole Hydrate

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1-Hydroxybenzotriazole hydrate, contains 11-16% water, 98%

1-Hydroxybenzotriazole (HOBt) hydrate

1-Hydroxybenzotriazole hydrate (HOBt)

N-Hydroxybenzotriazole monohydrate (HOBt)

1-Hydroxy-1H-benzotriazole Hydrate

1-Oxy-benztriazol Hydrate

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1-Hydroxybenzotriazole hydrate ,99%

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1-HYDROXYBENZOTRIAZOLE N-HYDRATE

1-HYDROXYBENZOTRIAZOLE MONOHYDRATE

1-HYDROXYBENZOTRIAZOLE HYDRATE

HOBT MONOHYDRATE

HOBT hydrate [1-Hydroxybenzotriazole hydrate]

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HOBT,1-Hydroxybenzotriazole hydrate

HOBT Monohydrate pure, 99%