ChemicalBook > CAS DataBase List > 4-Vinylpyridine

4-Vinylpyridine

Product Name
4-Vinylpyridine
CAS No.
100-43-6
Chemical Name
4-Vinylpyridine
Synonyms
4VP;4-Ethenylpyridine;4-vinylpyridine monomer;4-VINYLPYRIDINE;4-vinyl-pyridin;Vinylpyridine,4-;4-ethenyl-pyridin;4-Pyridylethylene;Pyridine, 4-vinyl-;gamma-vinylpyridine
CBNumber
CB8852582
Molecular Formula
C7H7N
Formula Weight
105.14
MOL File
100-43-6.mol
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4-Vinylpyridine Property

Melting point:
<25 °C
Boiling point:
62-65 °C/15 mmHg (lit.)
Density 
0.975 g/mL at 25 °C (lit.)
vapor pressure 
2.28hPa at 25℃
refractive index 
n20/D 1.549(lit.)
Flash point:
125 °F
storage temp. 
-20°C
solubility 
Chloroform, Methanol (Slightly)
form 
Liquid
pka
pK1:5.62(+1) (25°C)
color 
Clear colorless to yellow-brown
Water Solubility 
29 G/L (20 ºC)
BRN 
104506
Exposure limits
ACGIH: TWA 1 mg/m3
OSHA: TWA 2 mg/m3
NIOSH: IDLH 50 mg/m3; Ceiling 2 mg/m3
Stability:
Stable. Incompatible with strong acids, strong oxidizing agents.
LogP
1.36 at 20℃
CAS DataBase Reference
100-43-6(CAS DataBase Reference)
NIST Chemistry Reference
Pyridine, 4-ethenyl-(100-43-6)
EPA Substance Registry System
4-Vinylpyridine (100-43-6)
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Safety

Hazard Codes 
T
Risk Statements 
10-25-34-42/43-23/25
Safety Statements 
23-26-36/37/39-45-28A-16
RIDADR 
UN 3073 6.1/PG 2
WGK Germany 
3
RTECS 
UU1045000
8-10
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29333990
Hazardous Substances Data
100-43-6(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H226Flammable liquid and vapour

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
V3204
Product name
4-Vinylpyridine
Purity
contains 100 ppm hydroquinone as inhibitor, 95%
Packaging
5ml
Price
$27.5
Updated
2024/03/01
Sigma-Aldrich
Product number
V3204
Product name
4-Vinylpyridine
Purity
contains 100 ppm hydroquinone as inhibitor, 95%
Packaging
100ml
Price
$54
Updated
2024/03/01
TCI Chemical
Product number
V0150
Product name
4-Vinylpyridine (stabilized with HQ)
Purity
>95.0%(GC)
Packaging
25mL
Price
$40
Updated
2024/03/01
TCI Chemical
Product number
V0150
Product name
4-Vinylpyridine (stabilized with HQ)
Purity
>95.0%(GC)
Packaging
500mL
Price
$450
Updated
2024/03/01
Alfa Aesar
Product number
H36621
Product name
4-Vinylpyridine, 96%, low polymer, stab. with 100ppm hydroquinone
Packaging
25ml
Price
$43.65
Updated
2024/03/01
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4-Vinylpyridine Chemical Properties,Usage,Production

Description

4-vinylpyridine (4VP) is a pyridine derivative with a vinyl group in the 4-position. It is a colorless liquid, although impure samples are often brown. This compound belongs to a class of polar vinyl monomers that are important in many applications due to the ability of their polymers to form complexes of the electron-rich pyridine ring and to form polyelectrolytes through protonation or quaternization with alkyl or aryl halides. 4VP is sometimes used in biochemistry to alkylate protein cysteine residues. When compared to other alkylation agents, such as iodoacetamide, acrylamide, and N-ethylmaleimide, 4VP is less reactive, meaning the completion rate of cysteine alkylation is lower, but it also yields fewer side reactions[1].

Chemical Properties

dark brown to yellow liquid. 2.9g can be dissolved in 100g of water at 20℃, soluble in methanol, ether, benzene, acetone, and slightly soluble in ether. When exposed to light and heat, polymerization occurs, and 0.1%-0.2% hydroquinone is often added as a polymerization inhibitor during storage.

Uses

4-Vinylpyridine acts as a co-monomer in styrene-butadiene polymers to promote adhesion between the rubber compound and supporting fibers (or cords) in tires, belts and hoses. It serves as an intermediate for manufacturing chemicals and pharmaceuticals. Further, it is used as a reagent for the modification of cysteine. In addition to this, it is used to make poly(4-vinylpyridine) and elastomers.

Application

4-Vinylpyridine was used as a monomer in polymer chemistry and induced nonimmunological contact urticaria and allergic contact dermatitis. No crossreactivity is observed between pyridine derivatives. It can be copolymerized with many other monomers, in particular cationic monomers, such as acrylamide, acrylates, and also with other vinyl-based monomers (e.g. styrene).?

Preparation

4-Vinylpyridine is synthesized by reacting 4-picoline with formaldehyde to generate 4-pyridineethanol, which is then dehydrated.

Flammability and Explosibility

Flammable

Purification Methods

6 2 . Purify the monomer by fractional distillation under a good vacuum and in a N2 atmosphere and store it in sealed ampoules under N2, and keep it in the dark at -20o. The picrate has m 175-176o. [UV: Coleman & Fuoss J Am Chem Soc 77 5472 1955, Overberger et al. J Polymer Sci 27 381 1958, Petro & Smyth J Am Chem Soc 79 6142 1957.] It is used for alkylating SH groups in peptides [Anderson & Friedman Can J Biochem 49 1042 1971, Cawins & Friedman Anal Biochem 35 489 1970]. [Beilstein 20 II 170, 20 III/IV 2887, 20/6 V 213.]

References

[1] Baskaran, D. and A. Müller. “Anionic Polymerization of Polar Vinyl Monomers.” (2012): 623-655

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4-Vinylpyridine Suppliers

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View Lastest Price from 4-Vinylpyridine manufacturers

Hebei Chuanghai Biotechnology Co,.LTD
Product
4-Vinylpyridine 100-43-6
Price
US $5.00/KG
Min. Order
1KG
Purity
99% min
Supply Ability
100tons
Release date
2024-08-20
Hebei Mojin Biotechnology Co., Ltd
Product
4-Vinylpyridine 100-43-6
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-10-13
Career Henan Chemical Co
Product
4-Vinylpyridine 100-43-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
25kg
Release date
2019-07-11

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