ChemicalBook > CAS DataBase List > 4'-Hydroxypropiophenone
4'-Hydroxypropiophenone
- Product Name
- 4'-Hydroxypropiophenone
- CAS No.
- 70-70-2
- Chemical Name
- 4'-Hydroxypropiophenone
- Synonyms
- PHP;b360;B 360;H-365;Mepal;Frenon;Paroxon;VANATONE;Bio-Fren;Hypostat
- CBNumber
- CB8854142
- Molecular Formula
- C9H10O2
- Formula Weight
- 150.17
- MOL File
- 70-70-2.mol
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4'-Hydroxypropiophenone Property
- Melting point:
- 36-38 °C(lit.)
- Boiling point:
- 152-154 °C26 mm Hg(lit.)
- Density
- 1.09 g/cm3 (20℃)
- refractive index
- 1.5360 (estimate)
- FEMA
- 2005 | ACETANISOLE
- Flash point:
- >230 °F
- storage temp.
- Store below +30°C.
- solubility
- methanol: 0.1 g/mL, clear
- pka
- 8.87±0.26(Predicted)
- form
- Solid
- color
- White
- Water Solubility
- 0.34 g/l (15 ºC)
- Merck
- 14,7044
- BRN
- 907511
- LogP
- 2.030
- CAS DataBase Reference
- 70-70-2(CAS DataBase Reference)
- NIST Chemistry Reference
- 1-Propanone, 1-(4-hydroxyphenyl)-(70-70-2)
- EPA Substance Registry System
- 1-Propanone, 1-(4-hydroxyphenyl)- (70-70-2)
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Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 37-24/25-36-26
- WGK Germany
- 3
- RTECS
- UH1925000
- TSCA
- Yes
- HS Code
- 29145000
- Toxicity
- LD50 orally in Rabbit: 11800 mg/kg
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- H55405
- Product name
- 4′-Hydroxypropiophenone
- Purity
- 98%
- Packaging
- 100g
- Price
- $39.96
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 8.20692
- Product name
- 4′-Hydroxypropiophenone
- Purity
- for synthesis
- Packaging
- 100g
- Price
- $70.4
- Updated
- 2024/03/01
TCI Chemical
- Product number
- H0299
- Product name
- 4'-Hydroxypropiophenone
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $28
- Updated
- 2024/03/01
TCI Chemical
- Product number
- H0299
- Product name
- 4'-Hydroxypropiophenone
- Purity
- >98.0%(GC)
- Packaging
- 500g
- Price
- $161
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- A15314
- Product name
- 4'-Hydroxypropiophenone, 99%
- Packaging
- 100g
- Price
- $41.65
- Updated
- 2024/03/01
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4'-Hydroxypropiophenone Chemical Properties,Usage,Production
Chemical Properties
white powder
Uses
gonadotropic hormone inhibitor
Uses
Intermediates of Liquid Crystals
Uses
p-Hydroxypropiophenone is a 4-hydroxyphenyl ketone used in the preparation of potential antitumor agents. p-Hydroxypropiophenone is a lignin degrradation product.
Definition
ChEBI: P-Hydroxypropiophenone is a member of acetophenones.
Preparation
Preparation by Fries rearrangement of phenyl propionate
with aluminium chloride in refluxing carbon disulfide ? then at 130–150° for 2–3 h after solvent elimination (45–50%)
with aluminium chloride in nitrobenzene at 50° for 18 h (72%) or at ? 20° for 48 h (60%)
with aluminium chloride in nitromethane at 20° for 7–8 days (80%)
with aluminium chloride in chlorobenzene using microwave irradiation for ? 3 min at 106° (62%)
with aluminium chloride in ethylene dichloride at 95° for 5 h or in heptane at ? 80–90° for 7 h (36%), in benzene or in tetrachloroethane at 80°; with aluminium chloride in the presence of propionyl chloride at 50–60° for ? 6 h (49%)
with aluminium chloride without solvent at 50° for 10 h
with titanium tetrachloride in nitromethane at 20° for 7 days (56%) or ? without solvent at 50° for 10 h (39%)
with polyphosphoric acid at 100° (61%)
with boron trifluoride at 50° for 3 h (46%)
with stannic chloride at 50° for 3 h (10%).
Synthesis Reference(s)
The Journal of Organic Chemistry, 30, p. 2491, 1965 DOI: 10.1021/jo01018a528
Safety Profile
Poison by intraperitoneal, subcutaneous, and parenteral routes. An experimental teratogen. Other experimental reproductive effects. A flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.
target
Estrogen receptor
Purification Methods
4'-Hydroxypropiophenone [70-70-2] M 150.2, m 149o, b 140-145o/0.5mm, 8.05. Crystallise the phenone from H2O (m 149.8-150.2o) or EtOH (m 147o). The benzoyl derivative has m 117o, and the semicarbazone has m 183o (EtOH). [Beilstein 8 H 102, 8 II 104, 8 III 379.]
4'-Hydroxypropiophenone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4'-Hydroxypropiophenone manufacturers
Dorne Chemical Technology co. LTD
- Product
- 4'-Hydroxypropiophenone 70-70-2
- Price
- US $10.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 99%
- Supply Ability
- 10 ton
- Release date
- 2024-03-26
Shandong Hanjiang Chemical Co., Ltd
- Product
- 4'-Hydroxypropiophenone 70-70-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10T
- Release date
- 2024-01-19
Hebei Duling International Trade Co. LTD
- Product
- 4'-Hydroxypropiophenone 70-70-2
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2023-03-15
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