4'-Hydroxypropiophenone

Product Name: 4'-Hydroxypropiophenone
CAS No.: 70-70-2
Chemical Name: 4'-Hydroxypropiophenone
Synonyms: PHP;b360;B 360;H-365;Mepal;Frenon;Paroxon;VANATONE;Bio-Fren;Hypostat
CBNumber: CB8854142
Molecular Formula: C9H10O2
Formula Weight: 150.17
MOL File: 70-70-2.mol

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4'-Hydroxypropiophenone Property

Melting point:: 36-38 °C(lit.)
Boiling point:: 152-154 °C26 mm Hg(lit.)
Density: 1.09 g/cm3 (20℃)
refractive index: 1.5360 (estimate)
FEMA: 2005 | ACETANISOLE
Flash point:: >230 °F
storage temp.: Store below +30°C.
solubility: methanol: 0.1 g/mL, clear
pka: 8.87±0.26(Predicted)
form: Solid
color: White
Water Solubility: 0.34 g/l (15 ºC)
Merck: 14,7044
BRN: 907511
LogP: 2.030
CAS DataBase Reference: 70-70-2(CAS DataBase Reference)
NIST Chemistry Reference: 1-Propanone, 1-(4-hydroxyphenyl)-(70-70-2)
EPA Substance Registry System: 1-Propanone, 1-(4-hydroxyphenyl)- (70-70-2)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 36/37/38
Safety Statements: 37-24/25-36-26
WGK Germany: 3
RTECS: UH1925000
TSCA: Yes
HS Code: 29145000
Toxicity: LD50 orally in Rabbit: 11800 mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H55405
Product name: 4′-Hydroxypropiophenone
Purity: 98%
Packaging: 100g
Price: $39.96
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.20692
Product name: 4′-Hydroxypropiophenone
Purity: for synthesis
Packaging: 100g
Price: $70.4
Updated: 2024/03/01

TCI Chemical

Product number: H0299
Product name: 4'-Hydroxypropiophenone
Purity: >98.0%(GC)
Packaging: 25g
Price: $28
Updated: 2024/03/01

TCI Chemical

Product number: H0299
Product name: 4'-Hydroxypropiophenone
Purity: >98.0%(GC)
Packaging: 500g
Price: $161
Updated: 2024/03/01

Alfa Aesar

Product number: A15314
Product name: 4'-Hydroxypropiophenone, 99%
Packaging: 100g
Price: $41.65
Updated: 2024/03/01

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4'-Hydroxypropiophenone Chemical Properties,Usage,Production

Chemical Properties

white powder

Uses

gonadotropic hormone inhibitor

Uses

Intermediates of Liquid Crystals

Uses

p-Hydroxypropiophenone is a 4-hydroxyphenyl ketone used in the preparation of potential antitumor agents. p-Hydroxypropiophenone is a lignin degrradation product.

Definition

ChEBI: P-Hydroxypropiophenone is a member of acetophenones.

Preparation

Preparation by Fries rearrangement of phenyl propionate
with aluminium chloride in refluxing carbon disulfide ? then at 130–150° for 2–3 h after solvent elimination (45–50%)
with aluminium chloride in nitrobenzene at 50° for 18 h (72%) or at ? 20° for 48 h (60%)
with aluminium chloride in nitromethane at 20° for 7–8 days (80%)
with aluminium chloride in chlorobenzene using microwave irradiation for ? 3 min at 106° (62%)
with aluminium chloride in ethylene dichloride at 95° for 5 h or in heptane at ? 80–90° for 7 h (36%), in benzene or in tetrachloroethane at 80°; with aluminium chloride in the presence of propionyl chloride at 50–60° for ? 6 h (49%)
with aluminium chloride without solvent at 50° for 10 h
with titanium tetrachloride in nitromethane at 20° for 7 days (56%) or ? without solvent at 50° for 10 h (39%)
with polyphosphoric acid at 100° (61%)
with boron trifluoride at 50° for 3 h (46%)
with stannic chloride at 50° for 3 h (10%).

Synthesis Reference(s)

The Journal of Organic Chemistry, 30, p. 2491, 1965 DOI: 10.1021/jo01018a528

Safety Profile

Poison by intraperitoneal, subcutaneous, and parenteral routes. An experimental teratogen. Other experimental reproductive effects. A flammable liquid. When heated to decomposition it emits acrid smoke and irritating fumes. See also KETONES.

target

Estrogen receptor

Purification Methods

4'-Hydroxypropiophenone [70-70-2] M 150.2, m 149o, b 140-145o/0.5mm, 8.05. Crystallise the phenone from H2O (m 149.8-150.2o) or EtOH (m 147o). The benzoyl derivative has m 117o, and the semicarbazone has m 183o (EtOH). [Beilstein 8 H 102, 8 II 104, 8 III 379.]

4'-Hydroxypropiophenone Preparation Products And Raw materials

Raw materials

Carbon disulfide phenyl propionate

Preparation Products

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4'-Hydroxypropiophenone Suppliers

Americas 1 Austria 1 Belgium 1 Canada 4 China 392 Czech Republic 1 Europe 3 France 2 Germany 11 India 54 Japan 10 Singapore 1 Slovakia 1 South Korea 2 Switzerland 2 The Netherlands 1 Ukraine 2 United Kingdom 10 United States 57 Global 556

TOKYO CHEMICAL INDUSTRY CO., LTD.

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Kanto Chemical Co., Inc.

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View Lastest Price from 4'-Hydroxypropiophenone manufacturers

Dorne Chemical Technology co. LTD

Product: 4'-Hydroxypropiophenone 70-70-2
Price: US $10.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 99%
Supply Ability: 10 ton
Release date: 2024-03-26

Hebei Weibang Biotechnology Co., Ltd

Product: 4'-Hydroxypropiophenone 70-70-2
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-11

Shaanxi Dideu Medichem Co. Ltd

Product: 4'-Hydroxypropiophenone 70-70-2
Price: US $0.10/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10
Release date: 2024-08-04

70-70-2, 4'-HydroxypropiophenoneRelated Search:

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ACETANISOLE

AKOS 90580

AKOS BBS-00003225

AKOS BBS-00003216

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B 360

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