2-Methyltetrahydrofuran
- Product Name
- 2-Methyltetrahydrofuran
- CAS No.
- 96-47-9
- Chemical Name
- 2-Methyltetrahydrofuran
- Synonyms
- 2-MeTHF;METHF;METHYLTETRAHYDROFURAN;Furan, tetrahydro-2-methyl-;2-Methyloxolane;2-Methyltetrahydrofu;TETRAHYDRO-2-METHYLFURAN;2-Methyltetrahydrofuran,For Grignard reaction,anhydrous, stabilized;2 METHYLE Thf;Tetrahydrosylvan
- CBNumber
- CB8854728
- Molecular Formula
- C5H10O
- Formula Weight
- 86.13
- MOL File
- 96-47-9.mol
2-Methyltetrahydrofuran Property
- Melting point:
- -136 °C
- Boiling point:
- 78-80 °C(lit.)
- Density
- 0.86 g/mL at 25 °C(lit.)
- vapor pressure
- 136 hPa (20 °C)
- refractive index
- n20/D 1.406(lit.)
- Flash point:
- 10.4 °F
- storage temp.
- Store below +30°C.
- solubility
- 150g/l
- form
- Liquid
- color
- Clear colorless
- explosive limit
- 1.2-5.7%(V)
- Water Solubility
- 15 g/100 mL (25 C)
- FreezingPoint
- -136℃
- BRN
- 102448
- Dielectric constant
- 6.97
- Stability:
- Stable, but highly flammable. Incompatible with oxidizing agents, strong acids, strong bases. May form explosive peroxides in storage, so often supplied with an inhibitor added.
- LogP
- 1.1 at 20℃
- CAS DataBase Reference
- 96-47-9(CAS DataBase Reference)
- NIST Chemistry Reference
- Furan, tetrahydro-2-methyl-(96-47-9)
- EPA Substance Registry System
- Furan, tetrahydro-2-methyl- (96-47-9)
Safety
- Hazard Codes
- F,Xi
- Risk Statements
- 11-19-36/37-2017/11/19
- Safety Statements
- 16-23-39-33-26
- RIDADR
- UN 2536 3/PG 2
- WGK Germany
- 2
- RTECS
- LU2800000
- Autoignition Temperature
- 270 °C
- TSCA
- Yes
- HazardClass
- 3
- PackingGroup
- II
- HS Code
- 29321900
- Toxicity
- LD50 orally in Rabbit: > 300 - 2000 mg/kg LD50 dermal Rat > 2000 mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 85488
- Product name
- 2-Methyltetrahydrofuran
- Purity
- analytical standard
- Packaging
- 5ml
- Price
- $68.1
- Updated
- 2024/03/01
- Product number
- 85488
- Product name
- 2-Methyltetrahydrofuran
- Purity
- analytical standard
- Packaging
- 10ml
- Price
- $123
- Updated
- 2024/03/01
- Product number
- 8.21093
- Product name
- 2-Methyltetrahydrofuran
- Purity
- (stabilised) for synthesis
- Packaging
- 250ML
- Price
- $104
- Updated
- 2024/03/01
- Product number
- 8.21093
- Product name
- 2-Methyltetrahydrofuran
- Purity
- (stabilised) for synthesis
- Packaging
- 1L
- Price
- $204
- Updated
- 2024/03/01
- Product number
- 155810
- Product name
- 2-Methyltetrahydrofuran
- Purity
- ReagentPlus , ≥99.5%, contains 150-400 ppm BHT as stabilizer
- Packaging
- 2.5l
- Price
- $405
- Updated
- 2024/03/01
2-Methyltetrahydrofuran Chemical Properties,Usage,Production
Description
2-Methyltetrahydrofuran (MeTHF or 2-MTHF) is a bio-based solvent that is recognized as the most favorable of ether solvents. The relatively high boiling point (80?C) and low melting point (-137?C) provide a broad temperature range for a myriad of processing conditions. It is a potential greener solvent alternative for organic synthesis. It shows resistance to reduction by lithium making it a promising candidate as electrolytes in lithium batteries. Its polarity and Lewis base strength is intermediate between tetrahydrofuran (THF) and diethyl ether. The ring opening reaction of 2-MTHF has been studied using acid chloride and iodide.
Chemical Properties
Colorless liquid; ether-like odor. Solubility in waterincreases with a decrease in temperature. Freelysoluble in most organic solvents.
Uses
2-Methyltetrahydrofuran acts as a solvent in organic synthesis. It is considered as a replacement for terahydrofuran due to its higher reaction temperature and easy separation after reaction. It is also useful in the electrolyte formulation for secondary lithium electrodes and as a component in alternative fuels. Further, it is used as a solvent for spectroscopic studies at -1960C. It also acts as a solvent for Grignard reagent in organometallic reactions. In addition to this, it plays an important role as a motor fuel.
Uses
2-Methyltetrahydrofuran may be used as solvent for phosphatidylserine synthesis.
It may be used as an alternative solvent to:
- DMSO (dimethyl sulfoxide) or MTBE (methyl tertiary butyl ether) in the C-C bond forming reactions catalyzed by lyase enzyme.
- THF in the reaction between Grignard reagents and carbonyl compounds.
- Methylene chloride in some biphase reactions.
Uses
ZerO2 products?are rigorously degassed with highly pure inert gas providing solvents and solutions?(anhydrous if specified)?with very low residual oxygen content.
General Description
This product is a biorenewable and thus aligns with "Safer Solvents and Auxiliaries" and "Use of Renewable Feedstocks".
2-Methyltetrahydrofuran (2-MTHF), a 2-methyl substituted tetrahdrofuran, is a biomass derived solvent. It is a potential greener solvent alternative for organic synthesis. It shows resistance to reduction by lithium making it a promising candidate as electrolytes in lithium batteries. Its polarity and Lewis base strength is intermediate between tetrahydrofuran (THF) and diethyl ether. The ring opening reaction of 2-MTHF has been studied using acid chloride and iodide to form secondary chlorides and primary iodides respectively. On long term storage, tetrahydrofuran forms organic peroxides. This process can be suppressed by adding butylated hydroxytoluene (BHT) as a stabilizer. BHT removes the free radicals required for the peroxide formation.
Hazard
Flammable, dangerous fire risk.
Flammability and Explosibility
Highly flammable
Potential Exposure
Used as a chemical intermediate and asolvent.
First aid
If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.
storage
Color Code—Red: Flammability Hazard: Store ina flammable liquid storage area or approved cabinet awayfrom ignition sources and corrosive and reactive materials.Prior to working with methyltetrahydrofuran you should betrained on its proper handling and storage. Store in tightlyclosed containers in a cool, well-ventilated area. Where possible, automatically pump liquid from drums or other storage containers to process containers. Drums must beequipped with self-closing valves, pressure vacuum bungs,and flame arresters. Use only nonsparking tools and equipment, especially when opening and closing containers ofthis chemical. Wherever this chemical is used, handled,manufactured, or stored, use explosion-proof electricalequipment and fittings.
Shipping
Methyltetrahydrofuran requires a shipping labelof “FLAMMABLE LIQUID.” It falls in Hazard Class 3 andPacking Group II.
Purification Methods
Likely impurities are 2-methylfuran, methyldihydrofurans and hydroquinone (stabiliser, which is removed by distillation under reduced pressures). It is washed with 10% aqueous NaOH, dried, vacuum distilled from CaH2, passed through freshly activated alumina under nitrogen, and refluxed over sodium metal under vacuum. Store it over sodium. [Ling & Kevan J Phys Chem 80 592 1976.] Distil it from sodium under vacuum, and store it with sodium-potassium alloy (this treatment removes water and prevents the formation of peroxides). Alternatively, it can be freed from peroxides by treatment with ferrous sulfate and sodium bisulfate, then solid KOH, followed by drying with, and distilling from, sodium, or type 4A molecular sieves under argon. It may be difficult to remove *benzene if it is present as an impurity (can be readily detected by its ultraviolet absorption in the 249-268nm region). [Ichikawa & Yoshida J Phys Chem 88 3199 1984.] It has also been purifed by percolating through Al2O3 and fractionated collecting fraction b 79.5-80o. After degassing, the material is distilled onto degassed molecular sieves, then distilled onto anthracene and a sodium mirror. The solvent is then distilled from the green solution onto potassium mirror or sodium-potassium alloy, from which it is distilled again. [Mohammad & Kosower J Am Chem Soc 93 2713 1971.] It should be stored in the presence of 0.1% of hydroquinone or 2,6-di-tert-butyl –p-cresol as stabiliser. The R(+)-enantiomer has b 78-80o/atm and []D +27.5o (neat), and the S(-)-enantiomer has b 86o/atm and [] D -27.0o (neat) [Iffland & Davis J Org Chem 42 4150 1977, Gagnaire & Butt Bull Soc Chim Fr 312 1961, Beilstein 17 III/IV 60, 17/1 V 78.] HARMFUL VAPOURS.
Incompatibilities
Strong oxidizers may cause fire andexplosion
2-Methyltetrahydrofuran Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Methyltetrahydrofuran manufacturers
- Product
- 2-Methyltetrahydrofuran 96-47-9
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2021-07-14
- Product
- 2-Methyltetrahydrofuran 96-47-9
- Price
- US $50.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-22
- Product
- 2-Methyltetrahydrofuran 96-47-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-06-27