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Dicyclopropane methylamine

Product Name
Dicyclopropane methylamine
CAS No.
13375-29-6
Chemical Name
Dicyclopropane methylamine
Synonyms
AKOS MSC-0147;icyclopropylmethanamine;Bicyclopropylmethylamine;Dicyclopropanemethanamine;Dicyclopropane methylamine;DICYCLOPROPYL METHYL AMINE;1,1-dicyclopropylmethanamine;C,C-Dicyclopropyl-methylamine;1,1-dicyclopropylmethanamine 1;1,1-Dicyclopropane methylamine
CBNumber
CB8855624
Molecular Formula
C7H13N
Formula Weight
111.18
MOL File
13375-29-6.mol
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Dicyclopropane methylamine Property

Boiling point:
55-65 °C(Press: 11 Torr)
Density 
1.092±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
10.65±0.50(Predicted)
form 
liquid
color 
Yellow
CAS DataBase Reference
13375-29-6(CAS DataBase Reference)
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Safety

RIDADR 
2735
HazardClass 
8
PackingGroup 
Ⅲ
HS Code 
2921309990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

TRC
Product number
D439330
Product name
1,1-Dicyclopropylmethanamine
Packaging
5g
Price
$745
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0295142
Product name
DICYCLOPROPYL METHYL AMINE
Purity
95.00%
Packaging
5MG
Price
$501.51
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD02396
Product name
Dicyclopropyl methylamine
Packaging
2g
Price
$240
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD02396
Product name
Dicyclopropyl methylamine
Packaging
5G
Price
$400
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD02396
Product name
Dicyclopropyl methylamine
Packaging
250mg
Price
$65
Updated
2021/12/16
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Dicyclopropane methylamine Chemical Properties,Usage,Production

Uses

1,1-Dicyclopropylmethanamine is used as a reactant in the preparation of 4-dicyclopropylamino-7-aryl-7H-purines as CRF-1 antagonists with differentiated binding kinetic profiles.

Synthesis

1453-52-7

13375-29-6

General procedure for the synthesis of (dicyclopropylmethyl)amine from dicyclopropylketone oxime: In a 500 mL autoclave, 100 g of dicyclopropylketone oxime, 6 g of Ruanne nickel, 350 mL of water, and 10 g of sodium hydroxide were added in sequence. After replacing the air in the kettle with nitrogen three times, hydrogen was introduced. The hydrogen pressure of the reaction system was controlled to be 2 MPa, and the temperature was maintained at 70-80 °C for 4 hours. Upon completion of the reaction, the hydrogen pressure was released, the reaction mixture was cooled with continuous stirring, and the nickel catalyst in Nguyen was removed by filtration. The aqueous phase was extracted three times with 200 mL of dichloromethane, and the organic phases were combined and purified by distillation. Fractions from 100-110 °C were collected at a pressure of 100 mmHg to obtain the target product dicyclopropylmethylamine. About 81 g of product was finally obtained in 85.8% yield.

References

[1] Patent: CN104672093, 2016, B. Location in patent: Paragraph 0027-0028
[2] Synlett, 1999, # 4, p. 409 - 410
[3] Chemische Berichte, 1984, vol. 117, # 2, p. 856 - 858
[4] Helvetica Chimica Acta, 1963, vol. 46, p. 1059 - 1060
[5] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 1, p. 156 - 167

Dicyclopropane methylamine Preparation Products And Raw materials

Raw materials

Preparation Products

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Dicyclopropane methylamine Suppliers

China 92 Europe 1 France 1 Germany 2 India 2 Russia 1 Slovakia 1 Ukraine 1 United Kingdom 5 United States 16 Global 122
CHIMMED Company
Tel
--
Fax
--
Email
synthesis@chimmed.ru
Country
Russia
ProdList
5006
Advantage
81
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View Lastest Price from Dicyclopropane methylamine manufacturers

Longyan Tianhua Biological Technology Co., Ltd
Product
Dicyclopropane methylamine 13375-29-6
Price
US $15.00/KG
Min. Order
25KG
Purity
99.99
Supply Ability
999
Release date
2020-10-24
Career Henan Chemical Co
Product
Dicyclopropane methylamine 13375-29-6
Price
US $1.00/kg
Min. Order
1kg
Purity
as need
Supply Ability
as request
Release date
2018-12-23

13375-29-6, Dicyclopropane methylamineRelated Search:

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  • DICYCLOPROPYL METHYL AMINE
  • Dicyclopropane methylamine
  • AKOS MSC-0147
  • 1,1-Dicyclopropane methylamine
  • 1,1-dicyclopropylmethanamine 1
  • 1,1-DICYCLOPROPYLMETHANAMINE HYDROCHLORIDE
  • a-cyclopropylcyclopropanemethanamine
  • α-Cyclopropylcyclopropanemethanamine
  • 1,1-dicyclopropylmethanamine
  • (dicyclopropylmethyl)amine(SALTDATA: HCl)
  • Dicyclopropanemethanamine
  • Cyclopropanemethanamine, α-cyclopropyl-
  • C,C-Dicyclopropyl-methylamine
  • icyclopropylmethanamine
  • Bicyclopropylmethylamine
  • 13375-29-6
  • Pharmaceutical Intermediates