ChemicalBook > CAS DataBase List > GABOXADOL HYDROCHLORIDE

GABOXADOL HYDROCHLORIDE

Product Name: GABOXADOL HYDROCHLORIDE
CAS No.: 85118-33-8
Chemical Name: GABOXADOL HYDROCHLORIDE
Synonyms: MK 0928);Einecs 285-687-7;gaboxadol hydrochloride;Gaboxadol HCl (Lu 02-030;GaboxadolHydrochloride>Lu 02-030 (hydrochloride);Gaboxadol hydrochloride solid, >=98% (HPLC);THIP HYDROCHLORIDE (GABOXADOL) POST-SYNA PTIC GABA RE;4,5,6,7-Tetrahydro-isoxazolo[5,4-c]pyridin-3(2H)-one HCl;4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol, (HCl salt)
CBNumber: CB8903866
Molecular Formula: C6H9ClN2O2
Formula Weight: 176.6
MOL File: 85118-33-8.mol

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GABOXADOL HYDROCHLORIDE Property

Melting point:: 236 °C
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: ethanol: soluble0.91mg/mL
form: solid
color: white
Merck: 14,4321

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
RTECS: NY3396800
HS Code: 2934.99.9001

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H336May cause drowsiness or dizziness

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T101
Product name: Gaboxadol hydrochloride
Purity: solid, ≥98% (HPLC)
Packaging: 25mg
Price: $126.96
Updated: 2025/07/31

Sigma-Aldrich

Product number: T101
Product name: Gaboxadol hydrochloride
Purity: solid, ≥98% (HPLC)
Packaging: 100mg
Price: $217.12
Updated: 2025/07/31

TCI Chemical

Product number: G0405
Product name: Gaboxadol Hydrochloride
Purity: >98.0%(HPLC)
Packaging: 25mg
Price: $160
Updated: 2025/07/31

Cayman Chemical

Product number: 16355
Product name: Gaboxadol (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $48
Updated: 2024/03/01

Cayman Chemical

Product number: 16355
Product name: Gaboxadol (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $86
Updated: 2024/03/01

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GABOXADOL HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

GABAergic Agonist

Uses

As a molecular probe to study GABA receptors.

Uses

Gaboxadol hydrochloride has been used in cell migration and invasion assay to assess liver cancer cell migration.

Uses

Gaboxadol is a sleep aid drug used for the treatment of chronic pain and insomnia. Gaboxadol is also known to exhibit antidepressant like properties through its agonistic activities towards GABA sites .

General Description

Gaboxadol, also referred to as 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP), is a GABA site agonist. It has great affinity to the δ subunit of extrasynaptic high-affinity GABAA receptors. Gaboxadol was first developed for the treatment of schizophrenia, epilepsy, primary insomnia and Huntington′s disease. It can easily cross the blood-brain barrier and is rapidly absorbed by the body.

Biochem/physiol Actions

GABAA receptor agonist.

in vivo

Gaboxadol hydrochloride (intraperitoneal injection; 0.5, 1, 1.5, 2, 3, 4, or 5 mg/kg; once daily; three-day interval) normalizes the distance traveled by Fmr1 KO2 mice to WT activity levels at 0.5 mg/kg, additionally, this compound has no effect on locomotor activity in Fmr1 KO2 mice^[2].

Animal Model:	Fmr1?KO2 mice (deletion of the promoter and first exon of?Fmr1?resulting in mRNA and protein null mice)^[2]
Dosage:	0.5, 1, 1.5, 2, 3, 4, or 5 mg/kg
Administration:	Intraperitoneal injection
Result:	Normalized Hyperactivity Observed in?Fmr1?KO2 mice.

storage

Store at RT

GABOXADOL HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from GABOXADOL HYDROCHLORIDE manufacturers

Zhengzhou Anbu Chem Co.,Ltd

Product: GABOXADOL HYDROCHLORIDE 85118-33-8
Price: US $7.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1000KGS
Release date: 2023-11-23

Henan Bao Enluo International TradeCo.，LTD

Product: GABOXADOL HYDROCHLORIDE 85118-33-8
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 10000MT
Release date: 2023-06-09

85118-33-8, GABOXADOL HYDROCHLORIDERelated Search:

TRIMETHYLENE OXIDE Aniline hydrochloride Trimethylamine hydrochloride Methylamine hydrochloride Betaine hydrochloride Dimethylamine hydrochloride THIP HYDROCHLORIDE

4,5,6,7-tetrahydro-[1,2]oxazolo[5,4-c]pyridin-6-ium-3-olate

4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3(2H)-one monohydrochloride

THIP HYDROCHLORIDE (GABOXADOL) POST-SYNA PTIC GABA RE

THIP hydrochloride, 4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol hydrochloride

Einecs 285-687-7

Isoxazolo[5,4-c]pyridin-3(2H)-one, 4,5,6,7-tetrahydro-, Monohydrochloride

Gaboxadol hydrochloride solid, >=98% (HPLC)

4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3-ol, (HCl salt)

4,5,6,7-tetrahydro-[1,2]oxazolo[5,4-c]pyridin-6-ium-3-olate:hydrochloride

4,5,6,7-TETRAHYDROISOXAZOLO[5,4-C]PYRIDIN-3-OL HCL, GABOXADOL-HCL

gaboxadol hydrochloride

GaboxadolHydrochloride&gt

Lu 02-030 (hydrochloride)

Gaboxadol HCl (Lu 02-030

MK 0928)

Isoxazolo[5,4-c]pyridin-3(2H)-one, 4,5,6,7-tetrahydro-, hydrochloride (1:1)

Gaboxadol hydrochloride (THIP hydrochloride), GABAA receptor agonist and GABAC receptor antagonist

4,5,6,7-Tetrahydro-isoxazolo[5,4-c]pyridin-3(2H)-one HCl

85118-33-8