(4S,5R)-3-tert-butoxycarbony-2-(4-anisy)-4-phenyl-5-oxazolidinecarboxylic acid

Product Name: (4S,5R)-3-tert-butoxycarbony-2-(4-anisy)-4-phenyl-5-oxazolidinecarboxylic acid
CAS No.: 196404-55-4
Chemical Name: (4S,5R)-3-tert-butoxycarbony-2-(4-anisy)-4-phenyl-5-oxazolidinecarboxylic acid
Synonyms: Docetaxel intermedaite;side chain of docetaxel;Said chain of Docetaxel;Duoxi Purple Shirt Alcohol Side Chain;(4S,5R)-3-(tert-butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyl...;3-tert-Butoxycarbony-2-(4-anisyl)-4-phenyl-5-oxazolidinecarboxylic acid;(4S,5R)-2-(4-Methoxyphenyl)-N-t-boc-4-phenyl-oxazolidine-5-carboxylic acid;5R)-3-tert-butoxycarbony-2-(4-anisy)-4-phenyl-5-oxazolidinecarboxylic acid;(4S,5R)-2-(4-Methoxy-phenyl)-3-N-Boc-4-phenyl-3,5-oxazolidine carboxylic acid;(4S,5R)-3-tert-butoxycarbony-2-(4-anisy)-4-phenyl-5-oxazolidinecarboxylic acid
CBNumber: CB8946995
Molecular Formula: C22H25NO6
Formula Weight: 399.44
MOL File: 196404-55-4.mol

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(4S,5R)-3-tert-butoxycarbony-2-(4-anisy)-4-phenyl-5-oxazolidinecarboxylic acid Property

Melting point:: 134-138℃
Boiling point:: 573.8±50.0 °C(Predicted)
Density: 1.238
storage temp.: 2-8°C
pka: 2.99±0.60(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C22H25NO6/c1-22(2,3)29-21(26)23-17(14-8-6-5-7-9-14)18(20(24)25)28-19(23)15-10-12-16(27-4)13-11-15/h5-13,17-19H,1-4H3,(H,24,25)/t17-,18+,19?/m0/s1
InChIKey: MSVWUXLRSKRKFZ-PAMZHZACSA-N
SMILES: O1[C@@H](C(O)=O)[C@H](C2=CC=CC=C2)N(C(OC(C)(C)C)=O)C1C1=CC=C(OC)C=C1

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Safety

Safety Statements: 24/25
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B689800
Product name: (4S,5R)-3-tert-Butoxycarbony-2-(4-anisyl)-4-phenyl-5-oxazolidineCarboxylicAcid
Packaging: 100mg
Price: $140
Updated: 2021/12/16

TRC

Product number: B689800
Product name: (4S,5R)-3-tert-Butoxycarbony-2-(4-anisyl)-4-phenyl-5-oxazolidineCarboxylicAcid
Packaging: 250mg
Price: $195
Updated: 2021/12/16

TRC

Product number: B689800
Product name: (4S,5R)-3-tert-Butoxycarbony-2-(4-anisyl)-4-phenyl-5-oxazolidineCarboxylicAcid
Packaging: 500mg
Price: $305
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB33371
Product name: (4S,5R)-3-tert-Butoxycarbony-2-(4-anisyl)-4-phenyl-5-oxazolidine carboxylic acid
Packaging: 100g
Price: $500
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0031670
Product name: (4S,5R)-3-TERT-BUTOXYCARBONY-2-(4-ANISYL)-4-PHENYL-5-OXAZOLIDINECARBOXYLIC ACID
Purity: 95.00%
Packaging: 5MG
Price: $501.3
Updated: 2021/12/16

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(4S,5R)-3-tert-butoxycarbony-2-(4-anisy)-4-phenyl-5-oxazolidinecarboxylic acid Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

(4S,5R)-3-tert-Butoxycarbony-2-(4-anisyl)-4-phenyl-5-oxazolidine carboxylic acid is an intermediate/impurity for docetaxel hydrate (D494420). It can also be used to synthesize quinoline-docetaxel analogues which exhibit anticancer activity.

Synthesis

1531632-32-2

196404-55-4

The (4S,5R)-3-(tert-butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylic acid precursor obtained in the previous step (4.83 g, 9.88 mmol) was dissolved in 10 mL of methanol and 1.0 g of palladium hydroxide was added as a catalyst. Hydrogen was introduced into the reaction system at room temperature (pressure maintained at 20 psi) and the reaction was carried out for 1 h, during which the progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was filtered to remove the catalyst, and the filtrate was concentrated under reduced pressure and purified by column chromatography (eluent ratio of petroleum ether/ethyl acetate = 5:1) to afford (4S,5R)-3-(tert-butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyl-oxazolidine-5-carboxylic acid as a white solid (2.68 g, 67.9% yield).

References

[1] Patent: US2016/340365, 2016, A1. Location in patent: Paragraph 0140; 0141
[2] Patent: US2016/297784, 2016, A1. Location in patent: Paragraph 0149; 0164; 0165
[3] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 1, p. 194 - 203

(4S,5R)-3-tert-butoxycarbony-2-(4-anisy)-4-phenyl-5-oxazolidinecarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(4S,5R)-3-tert-butoxycarbony-2-(4-anisy)-4-phenyl-5-oxazolidinecarboxylic acid Suppliers

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View Lastest Price from (4S,5R)-3-tert-butoxycarbony-2-(4-anisy)-4-phenyl-5-oxazolidinecarboxylic acid manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: (4S,5R)-3-tert-butoxycarbony-2-(4-anisy)-4-phenyl-5-oxazolidinecarboxylic acid 196404-55-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-11-19

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Docetaxel Side Chain 196404-55-4
Price: US $0.00/g
Min. Order: 1g
Purity: 98%min HPLC
Supply Ability: 10000G
Release date: 2021-08-18

WUHAN FORTUNA CHEMICAL CO., LTD

Product: (4S,5R)-3-tert-butoxycarbony-2-(4-anisy)-4-phenyl-5-oxazolidinecarboxylic acid 196404-55-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%min
Supply Ability: 10kg
Release date: 2021-10-21

196404-55-4, (4S,5R)-3-tert-butoxycarbony-2-(4-anisy)-4-phenyl-5-oxazolidinecarboxylic acid Related Search:

Docetaxel Metabolite M4 7-{[(2,2,2,-TRICHLOROETHYL)OXY]CARBONYL} BACCATIN III 2',3'-O,N-[(S)-(p-Methoxybenzylidene)]-7-O-(triethylsilyl)paclitaxel Deacetyltaxol 7-O-(TRIETHYLSILYL) BACCATIN III 7,10-Dimethoxy-10-DAB III (4S,5R)-2,4-diphenyl-4,5-dihydrooxazole-5-carboxylic acid Cabazitaxel Docetaxel intermediate 10-Deacetylbaccatin III Paclitaxel Cabazitaxel N-1 (4S,5R)-3-Benzoyl-2-(4-methoxyphenyl)-4-phenyl-5-oxazolidinecarboxylic acid Docetaxel 10-Oxo Docetaxel 2-Debenzoyl-2-pentenoyl Docetaxel (2S,4S,5R)-3-Boc-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylic Acid Docetaxel Impurity 5

(4R,5R)-3-(2,2-Dimethylpropanoyl)-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid

(4S,5R)-3-tert-butoxycarbony-2-(4-anisyl)--phenyl-5-oxazolidinecarboxylic acid

(4S,5R)-2-(4-methoxyphenyl)-4-phenyl-3,5-Oxazolidinedicarboxylic acid 3-(1,1-dimethylethyl)ester

side chain of docetaxel

(4S,5R)-3-tert-butoxycarbony-2-(4-anisy)-4-phenyl-5-oxazolidinecarboxylic acid

(4S,5R)-2-(4-Methoxyphenyl)-4-phenyl-3,5-oxazolidinedicarboxylic acid 3-tert-butyl ester

(4S,5R)-3-tert-Butoxycarbony-2-(4-anisyl)-4-phenyl-5-oxazolidinecarboxylic acid

(4S,5R)-2-(4-Methoxy-phenyl)-3-N-Boc-4-phenyl-3,5-oxazolidine carboxylic acid

(4S,5R)-2-(4-Methoxyphenyl)-N-t-boc-4-phenyl-oxazolidine-5-carboxylic acid

(4S,5R)-3-(tert-Butoxycarbonyl)-2-(4-Methoxyphenyl)-4-phenyloxazolidine-5-carboxylic acid

Docetaxel intermedaite

(4S,5R)-3-tert-butoxycarbony-2-(4-anisyl)-4-phenyl-5-oxazolidinercarboxylicacid

(4S,5R)-3-(tert-Butoxycarbonyl)-2-(4-Methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid

Said chain of Docetaxel

(4S,5R)-2-(4-methoxyphenyl)-3-[(2-methylpropan-2-yl)oxycarbonyl]-4-phenyl-1,3-oxazolidine-5-carboxylic acid

3-tert-Butoxycarbony-2-(4-anisyl)-4-phenyl-5-oxazolidinecarboxylic acid

Docetaxel Side Chain：(4S,5R)-2-(4-Methoxyphenyl)-4-phenyl-3,5-oxazolidinedicarboxylic acid 3-tert-butyl ester

(4S,5R)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid, 98.5%

3,5-Oxazolidinedicarboxylic acid, 2-(4-methoxyphenyl)-4-phenyl-, 3-(1,1-dimethylethyl) ester, (4S,5R)-

(4S,5R)-3-tert-butoxycarbony-2-(4-anisy)-4-phenyl-5-oxazolidinecarboxylic acid ISO 9001：2015 REACH

(4S,5R)-3-tert-Butoxycarbonyl-2-(4-anisyl)-4-phenyl-5-oxazolidinecarboxylic acid

5R)-3-tert-butoxycarbony-2-(4-anisy)-4-phenyl-5-oxazolidinecarboxylic acid

(4S,5R)-3-(tert-butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyl...

196404-55-4 (4S,5R)-3-tert-butoxycarbony-2-(4-anisy)-4-phenyl-5-oxazolidinecarboxylic acid

3-(1,1-Dimethylethyl) hydrogen (4S,5R)-2-(4-methoxyphenyl)-4-phenyl-3,5-oxazolidinedicarboxylate

(4S,5R)-3-tert-butoxycarbony-2-(4-anisy)-4-phenyl-5-oxazolidinecarboxylic acid, 10 mM in DMSO

(4S,5R)-3-(tert-Butoxy)-2-(4-methoxyphenyl)-4-phenyl-5-oxazolidinecarboxylicacid

Duoxi Purple Shirt Alcohol Side Chain

(4S,5R)-3-(tert-Butoxycarbonyl)-2-(4-methoxyphenyl)-4-phenyloxazolidine-5-carboxylic acid - [B90020]

3-(tert-Butyl) hydrogen (4S,5R)-2-(4-methoxy-phenyl)-4-phenyl-3,5-oxazolidinedicarboxylate

196404-55-4

API