ChemicalBook > CAS DataBase List > 5-Hydroxy-3-methylpyridine-2-carbonitrile

5-Hydroxy-3-methylpyridine-2-carbonitrile

Product Name
5-Hydroxy-3-methylpyridine-2-carbonitrile
CAS No.
228867-86-5
Chemical Name
5-Hydroxy-3-methylpyridine-2-carbonitrile
Synonyms
5-h;5-hydroxy-3-methylpicolinonitrile;5-Hydroxy-3-methylpyridin-2-carbonitrile;5-hydroxy-3-Methyl-2-Pyridinecarbonitrile;2-Carbonitrile-5-Hydroxy-3-methylpyridine;5-Hydroxy-3-methylpyridine-2-carbonitrile;2-Pyridinecarbonitrile, 5-hydroxy-3-methyl-;2-Pyridinecarbonitrile,5-hydroxy-3-methyl-(9CI);5-Hydroxy-3-methylpyridine-2-carbonitrile ISO 9001：2015 REACH;5-HYDROXY-3-METHYLPYRIDINE-2-CARBONITRILE,PURITY:95% MIN(HPLC)
CBNumber
CB8947826
Molecular Formula
C7H6N2O
Formula Weight
134.14
MOL File
228867-86-5.mol
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5-Hydroxy-3-methylpyridine-2-carbonitrile Property

Boiling point:
419.7±45.0 °C(Predicted)
Density 
1.26±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
3.36±0.23(Predicted)
Appearance
Light yellow to yellow Solid
CAS DataBase Reference
228867-86-5(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A416085
Product name
5-Hydroxy-3-methylpicolinonitrile
Packaging
10mg
Price
$45
Updated
2021/12/16
TRC
Product number
A416085
Product name
5-Hydroxy-3-methylpicolinonitrile
Packaging
50mg
Price
$130
Updated
2021/12/16
TRC
Product number
A416085
Product name
5-Hydroxy-3-methylpicolinonitrile
Packaging
100mg
Price
$200
Updated
2021/12/16
AK Scientific
Product number
1437AB
Product name
5-Hydroxy-3-methylpicolinonitrile
Packaging
5g
Price
$1670
Updated
2021/12/16
Matrix Scientific
Product number
089701
Product name
5-Hydroxy-3-methylpicolinonitrile
Purity
95+%
Packaging
1g
Price
$756
Updated
2021/12/16
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5-Hydroxy-3-methylpyridine-2-carbonitrile Chemical Properties,Usage,Production

Synthesis

252056-70-5

228867-86-5

Using 5-amino-3-methylpyridine-2-carbonitrile (18.0 g, 135 mmol) as raw material, a 1.6 M aqueous solution of sodium nitrite (10.3 g, 149 mmol) was slowly added to a mixture of its water (243 mL) and concentrated sulfuric acid (67.5 mL) at 0 °C. The reaction mixture was gradually warmed to room temperature and subsequently stirred at 100 °C for 3 hours. Upon completion of the reaction, it was cooled to room temperature and extracted with ethyl acetate (3 x 75 mL). The organic layers were combined, washed sequentially with water (2 × 75 mL) and saturated aqueous sodium chloride solution (2 × 75 mL), dried, filtered and concentrated under reduced pressure to give 5-hydroxy-3-methylpyridine-2-carbonitrile (16 g, 120 mmol, 89% yield) as a yellow solid.1H NMR (400 MHz, DMSO-d6) δ 11.07 (brs, 1H) 8.08 (d, J = 2.6Hz, 1H), 7.20 (d, J = 2.3Hz, 1H), 2.40 (s, 3H).

References

[1] Patent: WO2015/155626, 2015, A1. Location in patent: Page/Page column 89; 90
[2] Patent: WO2017/51294, 2017, A1. Location in patent: Page/Page column 57; 58
[3] Patent: WO2017/51303, 2017, A1. Location in patent: Page/Page column 72; 73
[4] Journal of Medicinal Chemistry, 2018, vol. 61, # 10, p. 4476 - 4504
[5] Patent: WO2017/51276, 2017, A1. Location in patent: Page/Page column 99; 10016 g

5-Hydroxy-3-methylpyridine-2-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-Hydroxy-3-methylpyridine-2-carbonitrile manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
5-Hydroxy-3-methylpyridine-2-carbonitrile 228867-86-5
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-05-25
Zhuozhou Wenxi import and Export Co., Ltd
Product
5-Hydroxy-3-methylpyridine-2-carbonitrile 228867-86-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
5-Hydroxy-3-methylpyridine-2-carbonitrile 228867-86-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

228867-86-5, 5-Hydroxy-3-methylpyridine-2-carbonitrileRelated Search:

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