5-Hydroxy-3-methylpyridine-2-carbonitrile
- Product Name
- 5-Hydroxy-3-methylpyridine-2-carbonitrile
- CAS No.
- 228867-86-5
- Chemical Name
- 5-Hydroxy-3-methylpyridine-2-carbonitrile
- Synonyms
- 5-h;5-hydroxy-3-methylpicolinonitrile;5-Hydroxy-3-methylpyridin-2-carbonitrile;5-hydroxy-3-Methyl-2-Pyridinecarbonitrile;2-Carbonitrile-5-Hydroxy-3-methylpyridine;5-Hydroxy-3-methylpyridine-2-carbonitrile;2-Pyridinecarbonitrile, 5-hydroxy-3-methyl-;2-Pyridinecarbonitrile,5-hydroxy-3-methyl-(9CI);5-Hydroxy-3-methylpyridine-2-carbonitrile ISO 9001：2015 REACH;5-HYDROXY-3-METHYLPYRIDINE-2-CARBONITRILE,PURITY:95% MIN(HPLC)
- CBNumber
- CB8947826
- Molecular Formula
- C7H6N2O
- Formula Weight
- 134.14
- MOL File
- 228867-86-5.mol
5-Hydroxy-3-methylpyridine-2-carbonitrile Property
- Boiling point:
- 419.7±45.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 3.36±0.23(Predicted)
- Appearance
- Light yellow to yellow Solid
- CAS DataBase Reference
- 228867-86-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A416085
- Product name
- 5-Hydroxy-3-methylpicolinonitrile
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- A416085
- Product name
- 5-Hydroxy-3-methylpicolinonitrile
- Packaging
- 50mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- A416085
- Product name
- 5-Hydroxy-3-methylpicolinonitrile
- Packaging
- 100mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 1437AB
- Product name
- 5-Hydroxy-3-methylpicolinonitrile
- Packaging
- 5g
- Price
- $1670
- Updated
- 2021/12/16
- Product number
- 089701
- Product name
- 5-Hydroxy-3-methylpicolinonitrile
- Purity
- 95+%
- Packaging
- 1g
- Price
- $756
- Updated
- 2021/12/16
5-Hydroxy-3-methylpyridine-2-carbonitrile Chemical Properties,Usage,Production
Synthesis
252056-70-5
228867-86-5
Using 5-amino-3-methylpyridine-2-carbonitrile (18.0 g, 135 mmol) as raw material, a 1.6 M aqueous solution of sodium nitrite (10.3 g, 149 mmol) was slowly added to a mixture of its water (243 mL) and concentrated sulfuric acid (67.5 mL) at 0 °C. The reaction mixture was gradually warmed to room temperature and subsequently stirred at 100 °C for 3 hours. Upon completion of the reaction, it was cooled to room temperature and extracted with ethyl acetate (3 x 75 mL). The organic layers were combined, washed sequentially with water (2 × 75 mL) and saturated aqueous sodium chloride solution (2 × 75 mL), dried, filtered and concentrated under reduced pressure to give 5-hydroxy-3-methylpyridine-2-carbonitrile (16 g, 120 mmol, 89% yield) as a yellow solid.1H NMR (400 MHz, DMSO-d6) δ 11.07 (brs, 1H) 8.08 (d, J = 2.6Hz, 1H), 7.20 (d, J = 2.3Hz, 1H), 2.40 (s, 3H).
References
[1] Patent: WO2015/155626, 2015, A1. Location in patent: Page/Page column 89; 90
[2] Patent: WO2017/51294, 2017, A1. Location in patent: Page/Page column 57; 58
[3] Patent: WO2017/51303, 2017, A1. Location in patent: Page/Page column 72; 73
[4] Journal of Medicinal Chemistry, 2018, vol. 61, # 10, p. 4476 - 4504
[5] Patent: WO2017/51276, 2017, A1. Location in patent: Page/Page column 99; 10016 g
5-Hydroxy-3-methylpyridine-2-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
5-Hydroxy-3-methylpyridine-2-carbonitrile Suppliers
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View Lastest Price from 5-Hydroxy-3-methylpyridine-2-carbonitrile manufacturers
- Product
- 5-Hydroxy-3-methylpyridine-2-carbonitrile 228867-86-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-25
- Product
- 5-Hydroxy-3-methylpyridine-2-carbonitrile 228867-86-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 5-Hydroxy-3-methylpyridine-2-carbonitrile 228867-86-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08