ChemicalBook > CAS DataBase List > Exatecan

Exatecan

Product Name
Exatecan
CAS No.
171335-80-1
Chemical Name
Exatecan
Synonyms
exatecan alideximer;DX 8951;CS-147;Exatecan;1 Exatecan;Exatecan Base;Exatecan Impurity;Irinotecan Impurity 36;(1S,9S)-1-Amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-2,3,12,15-tetrahydrobenzo[de]pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-10,13(1H,9H)-dione;(1S,9S)-1-Amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-2,3,12,15-tetrahydrobenzo[de]pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-10,13(1H,9H)-dione
CBNumber
CB91009566
Molecular Formula
C24H22FN3O4
Formula Weight
435.45
MOL File
171335-80-1.mol
More
Less

Exatecan Property

Boiling point:
818.4±65.0 °C(Predicted)
Density 
1.53±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C,protect from light
solubility 
Soluble in DMSO
form 
Solid
pka
11.19±0.40(Predicted)
color 
Off-white to gray
InChIKey
ZVYVPGLRVWUPMP-FYSMJZIKSA-N
SMILES
N1C2C3=C(CC[C@H](N)C3=C3CN4C(C=13)=CC1[C@](CC)(O)C(=O)OCC=1C4=O)C(C)=C(F)C=2
More
Less

Safety

RIDADR 
UN2811
HazardClass 
6.1
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3519
Product name
Exatecan
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$77.14
Updated
2025/07/31
Sigma-Aldrich
Product number
SML3519
Product name
Exatecan
Purity
≥98% (HPLC)
Packaging
25 mg
Price
$328
Updated
2025/07/31
American Custom Chemicals Corporation
Product number
API0005207
Product name
EXATECAN
Purity
95.00%
Packaging
5MG
Price
$1498.8
Updated
2021/12/16
ChemScene
Product number
CS-2951
Product name
Exatecan
Packaging
500mg
Price
$2480
Updated
2021/12/16
ChemScene
Product number
CS-2951
Product name
Exatecan
Packaging
100mg
Price
$2600
Updated
2021/12/16
More
Less

Exatecan Chemical Properties,Usage,Production

Description

Exatecan is a hexacyclic chemical compound analogous to camptothecin and used as a payload in ADC research. Exatecan mesylate is used as an inhibitor of DNA topoisomerase I, which plays a key role in DNA replication, transcription, and recombination.

Definition

ChEBI: Exatecan is a pyranoindolizinoquinoline.

Biological Activity

Exatecan (DX-8951) is a DNA topoisomerase I (topoisomerase I) inhibitor with IC50 of 2.2 μM (0.975 μg/mL) for cancer research.

in vitro

Exatecan is a potent topoisomerase I inhibitor, with an IC 50 of 0.975 μg/mL. Exatecan Mesylate (DX-8951f) significantly inhibits the proliferation of several cancer cell lines, with mean GI 50 s of 2.02 ng/mL, 2.92 ng/mL, 1.53 ng/mL, and 0.877 ng/mL for breast cancer cells, colon cancer cells, stomach cancer cells and lung cancer cells, respectively. Exatecan Mesylate (DX-8951f) displays cytotoxic activities against PC-6, PC-6/SN2-5 cells, with mean GI 50 s of 0.186 and 0.395 ng/mL, respctively. Exatecan Mesylate (34 nM) stabilizes DNA-TopoI complexes in PC-6 and PC-6/SN2-5 cells.

in vivo

Exatecan Mesylate (DX-8951f, 3.325-50 mg/kg, i.v.) exhibits antitumor activities in the mice model bearing tumor cells, without toxic death. Exatecan Mesylate (15, 25 mg/kg, i.v.) hightly inhibits MIA-PaCa, BxPC-3 primary tumor growth in the MIA-PaCa-2 early-stage model and early-stage model of BxPC-3. Exatecan Mesylate (15, 25 mg/kg, i.v.) also significantly suppresses BxPC-3 lymphatic metastasis and completely eliminates lung metastasis in the BxPC-3 late-stage cancer model.

Exatecan Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Exatecan Suppliers

China 125 India 4 United States 14 Global 143
Shanghai Tekanbio Pharm-Tech Co., Ltd.
Tel
021-50896099 18017206244
Fax
QQ：3268640975
Email
sales@tekanbio.com
Country
China
ProdList
107
Advantage
58
WuYan Pharmaceutical Technology (Shanghai) Co., Ltd.
Tel
18621565901
Fax
021-61114075
Email
sales@wuyanpharm.com
Country
China
ProdList
117
Advantage
55
YJ Pharma
Tel
13962794339
Email
3686954964@qq.com
Country
China
ProdList
270
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
Chemvon Biotechnology Co., Ltd
Tel
021-50790412
Fax
+86-21-50790419
Email
info@chemvon.com
Country
China
ProdList
371
Advantage
57
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
Advantage
59
Shanghai Sphchem Co., Ltd.
Tel
021-56491756 13512199871
Fax
021-5649-1756
Email
2819742715@qq.com
Country
China
ProdList
4000
Advantage
55
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Shenzhen HwaGen Pharmaceutical Co.,Ltd
Tel
17722620669
Fax
0752-5319394
Email
liangcong.yi@rafflespt.com
Country
China
ProdList
279
Advantage
58
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7782
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18333
Advantage
56
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9637
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
15873
Advantage
55
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
Advantage
60
Shanghai Biolang biotechnology Co.,Ltd
Tel
17764003753
Fax
13669031409
Email
2326587775@qq.com
Country
China
ProdList
188
Advantage
55
Shanghai Biolang biotechnology Co.,Ltd
Tel
17764003753
Fax
13669031409
Email
2326587775@qq.com
Country
China
ProdList
188
Advantage
55
Guangzhou Zhiya Chemdrugs Co.,Ltd
Tel
18122150900
Fax
QQ:2869377561
Email
sculk28@163.com
Country
China
ProdList
646
Advantage
55
Nanjing XiLang Chemical Products Co., Ltd.
Tel
18936048580
Email
chemxilang@163.com
Country
China
ProdList
3909
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shanghai Rechem science Co., Ltd.
Tel
021-31433387 15618786686
Fax
QQ:1369748377
Email
sales@rechemscience.com
Country
China
ProdList
2991
Advantage
58
ChengDu TongChuangYuan Pharmaceutical Co.Ltd
Tel
028-83379370 13880556291
Fax
028-87747383
Email
tcy@tcypharm.com
Country
China
ProdList
7218
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Henan Anky Chemical Technology Co., Ltd.
Tel
17836913271
Fax
0374-8348899
Email
3224305243@qq.com
Country
China
ProdList
2944
Advantage
58
Wellman Pharmaceutical Group Limited
Tel
027-027-83778875 15807197853
Fax
027-83991220
Email
15807197853@163.com
Country
China
ProdList
3931
Advantage
58
Zhengzhou JACS Chemical Co., Ltd.
Tel
0371-0371-86259281 15981966935
Fax
0371-86259281
Email
jacschem@163.com
Country
China
ProdList
2005
Advantage
58
Jiaxing Deyi Chemical Co., Ltd.
Tel
86-0573-85866609 13325730825
Fax
0573-85866609
Email
945717149@qq.com
Country
China
ProdList
8596
Advantage
58
Hubei widely chemical technology Co., Ltd.
Tel
027-83778895 18602735115
Fax
027-51119224
Email
18602735115@163.com
Country
China
ProdList
2005
Advantage
64
Shanghai Zhibang Biological Medicine Co., LTD
Tel
021-54285032 18116461626
Fax
021-54285032
Email
25493162@qq.com
Country
China
ProdList
148
Advantage
58
Jinan Kabotang Biological Technology Co.,Ltd.
Tel
0531-61320525 15866703830
Email
figo.gao@foxmail.com
Country
China
ProdList
5178
Advantage
58
Abydos Scientific
Tel
025-84767922 18936879710
Email
sales@abydoscientific.com
Country
China
ProdList
1002
Advantage
58
Hunan chemfish Scientific co.,ltd
Tel
19313119705 15707487186
Email
sales@chemfish.com
Country
China
ProdList
4961
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
Shochem(Shanghai)Co.,Ltd
Tel
+86-021-51783479 +86-13816874662
Fax
021-50800795
Email
info@shochem.com
Country
China
ProdList
307
Advantage
58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
Tel
meitaochem@126.com
Email
meitaochem@126.com
Country
China
ProdList
19103
Advantage
58
Zhengzhou Alfa Chemical Co.,Ltd
Tel
+8618530059196
Email
sale04@alfachem.cn
Country
China
ProdList
11784
Advantage
58
Finetech Industry Limited
Tel
+86-27-8746-5837 +8619945049750
Fax
86 27 87772287
Email
info@finetechnology-ind.com
Country
China
ProdList
9629
Advantage
58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471
Email
sales@sarms4muscle.com
Country
China
ProdList
10473
Advantage
58
ANHUI WITOP BIOTECH CO., LTD
Tel
+8615255079626
Email
eric@witopchemical.com
Country
China
ProdList
23541
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418684 +8618949823763
Fax
0086-551-65418684
Email
sales@tnjchem.com
Country
China
ProdList
25356
Advantage
58
Guangzhou TongYi biochemistry technology Co.,LTD
Tel
+8613073028829
Email
tongyibiochem@163.com
Country
China
ProdList
2995
Advantage
58
Baoji Guokang Healthchem Co., Ltd.
Tel
+86-0917-3909592 +86-13892490616
Fax
09173909592
Email
gksales1@gk-bio.com
Country
China
ProdList
9209
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30229
Advantage
58
Chemwill Asia Co.,Ltd.
Tel
86-21-51086038
Fax
86-21-51861608
Email
chemwill_asia@126.com
Country
CHINA
ProdList
23912
Advantage
58
Anqing Runke Biomedical Technology Co., Ltd.
Tel
0512-68716880 19984816880
Fax
0556-5282330
Email
sales@growingchem.com
Country
China
ProdList
307
Advantage
58
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
+86-0519-85788828 +86-13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
3934
Advantage
58
Shochem(Shanghai) Co.,Ltd
Tel
86-21-50800795
Email
info@shochem.com
Country
CHINA
ProdList
288
Advantage
58
Shanghai Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
021-58955996
Email
info@chemexpress.com
Country
China
ProdList
823
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49975
Advantage
58
Shaanxi Dideu Medichem Co. Ltd
Tel
+86-29-81139210 +86-18192627656
Fax
+86-29-88380327
Email
1059@dideu.com
Country
China
ProdList
3588
Advantage
58
Guangzhou Younan Technology Co., Ltd
Tel
020-82000279 18988941452
Fax
QQ：3283937693
Email
YN_research@163.com
Country
China
ProdList
3011
Advantage
58
More
Less

View Lastest Price from Exatecan manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Exatecan 171335-80-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1MT
Release date
2025-09-11
Moxin Chemicals
Product
Exatecan 171335-80-1
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
99%+ HPLC
Supply Ability
1000
Release date
2025-05-23
Henan Aochuang Chemical Co.,Ltd.
Product
Exatecan 171335-80-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13

171335-80-1, ExatecanRelated Search:

CHLOROPHOSPHONAZO III Piroxicam Methyl salicylate Bensulfuron methyl Kresoxim-methyl Thiophanate-methyl Methyl (+)-Camptothecin 7,11-Diethyl-10-hydroxycaMptothecin Irinotecan Impurity 24 RPR121056A 4-Piperidinopiperidine 10-O-Acetyl SN-38 12-Hydroxy Irinotecan 10-Hydroxycamptothecin 7-Ethylcamptothecin 7-Ethyl-10-(4-amino-1-piperidino)carbonyloxycamptothecin 7-Ethyl-10-hydroxycamptothecin

  • 10H,13H-BENZO[DE]PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLINE-10,13-DIONE, 1-AMINO-9-ETHYL-5-FLUORO-1,2,3,9,12,15-HEXAHYDRO-9-HYDROXY-4-METHYL-, (1S,9S)-, MONOMETHANESULFONATE (SALT)
  • exatecan alideximer
  • (1S,9S)-1-Amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-10H,13H-benzo(de)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-10,13-dione
  • Exatecan
  • DX 8951
  • CS-147
  • Exatecan Impurity
  • 10H,13H-Benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione, 1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (1S,9S)-
  • Irinotecan Impurity 36
  • 1 Exatecan
  • Exatecan Base
  • (1S,9S)-1-amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-1,2,3,9,12,15-hexahydro-10H,13H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione
  • (1S,9S)-1-Amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-2,3,12,15-tetrahydrobenzo[de]pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-10,13(1H,9H)-dione
  • (1S,9S)-1-amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-1,2,3,9,12,15-hexahydro-10H,13H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione
  • (1S,9S)-1-Amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-2,3,12,15-tetrahydrobenzo[de]pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-10,13(1H,9H)-dione
  • 171335-80-1
  • 1711335-80-1