Exatecan

Product Name: Exatecan
CAS No.: 171335-80-1
Chemical Name: Exatecan
Synonyms: exatecan alideximer;DX 8951;CS-147;Exatecan;1 Exatecan;Exatecan Base;Exatecan Impurity;Irinotecan Impurity 36;(1S,9S)-1-Amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-2,3,12,15-tetrahydrobenzo[de]pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-10,13(1H,9H)-dione;(1S,9S)-1-Amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-10H,13H-benzo(de)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-10,13-dione
CBNumber: CB91009566
Molecular Formula: C24H22FN3O4
Formula Weight: 435.45
MOL File: 171335-80-1.mol

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Exatecan Property

Boiling point:: 818.4±65.0 °C(Predicted)
Density: 1.53±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C,protect from light
solubility: Soluble in DMSO
form: Solid
pka: 11.19±0.40(Predicted)
color: Off-white to gray

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0005207
Product name: EXATECAN
Purity: 95.00%
Packaging: 5MG
Price: $1498.8
Updated: 2021/12/16

ChemScene

Product number: CS-2951
Product name: Exatecan
Packaging: 500mg
Price: $2480
Updated: 2021/12/16

ChemScene

Product number: CS-2951
Product name: Exatecan
Packaging: 100mg
Price: $2600
Updated: 2021/12/16

ChemScene

Product number: CS-2951
Product name: Exatecan
Packaging: 1g
Price: $4160
Updated: 2021/12/16

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Exatecan Chemical Properties,Usage,Production

Description

Exatecan is a hexacyclic chemical compound analogous to camptothecin and used as a payload in ADC research. Exatecan mesylate is used as an inhibitor of DNA topoisomerase I, which plays a key role in DNA replication, transcription, and recombination.

Definition

ChEBI: Exatecan is a pyranoindolizinoquinoline.

Biological Activity

Exatecan (DX-8951) is a DNA topoisomerase I (topoisomerase I) inhibitor with IC50 of 2.2 μM (0.975 μg/mL) for cancer research.

in vitro

Exatecan is a potent topoisomerase I inhibitor, with an IC 50 of 0.975 μg/mL. Exatecan Mesylate (DX-8951f) significantly inhibits the proliferation of several cancer cell lines, with mean GI 50 s of 2.02 ng/mL, 2.92 ng/mL, 1.53 ng/mL, and 0.877 ng/mL for breast cancer cells, colon cancer cells, stomach cancer cells and lung cancer cells, respectively. Exatecan Mesylate (DX-8951f) displays cytotoxic activities against PC-6, PC-6/SN2-5 cells, with mean GI 50 s of 0.186 and 0.395 ng/mL, respctively. Exatecan Mesylate (34 nM) stabilizes DNA-TopoI complexes in PC-6 and PC-6/SN2-5 cells.

in vivo

Exatecan Mesylate (DX-8951f, 3.325-50 mg/kg, i.v.) exhibits antitumor activities in the mice model bearing tumor cells, without toxic death. Exatecan Mesylate (15, 25 mg/kg, i.v.) hightly inhibits MIA-PaCa, BxPC-3 primary tumor growth in the MIA-PaCa-2 early-stage model and early-stage model of BxPC-3. Exatecan Mesylate (15, 25 mg/kg, i.v.) also significantly suppresses BxPC-3 lymphatic metastasis and completely eliminates lung metastasis in the BxPC-3 late-stage cancer model.

Exatecan Preparation Products And Raw materials

Raw materials

Preparation Products

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Exatecan Suppliers

China 107 India 3 United States 13 Global 123

Shanghai Tekanbio Pharm-Tech Co., Ltd.

Tel: 021-50896099 18017206244
Fax: QQ：3268640975
Email: sales@tekanbio.com
Country: China
ProdList: 108
Advantage: 58

WuYan Pharmaceutical Technology (Shanghai) Co., Ltd.

Tel: 021-61001086 13671938079
Fax: 021-61114075
Email: sales@wuyanpharm.com
Country: China
ProdList: 105
Advantage: 55

Shanghai Troedsson Technology Co., LTD

Tel: 18117455885
Email: qihongchem@163.com
Country: China
ProdList: 9323
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel: 021-50182298 021-50180596
Fax: +86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2208
Advantage: 55

Chemvon Biotechnology Co., Ltd

Tel: 021-50790412
Fax: +86-21-50790419
Email: info@chemvon.com
Country: China
ProdList: 371
Advantage: 57

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
Advantage: 59

Shanghai Sphchem Co., Ltd.

Tel: 021-56491756 13512199871
Fax: 021-5649-1756
Email: 2819742715@qq.com
Country: China
ProdList: 4000
Advantage: 55

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14055
Advantage: 65

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Shenzhen HwaGen Pharmaceutical Co.,Ltd

Tel: 18927339850
Fax: 0752-5319394
Email: xiaodong.shi@rafflespt.com
Country: China
ProdList: 237
Advantage: 58

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View Lastest Price from Exatecan manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: Exatecan 171335-80-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

Zhuozhou Wenxi import and Export Co., Ltd

Product: Exatecan 171335-80-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Exatecan 171335-80-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

171335-80-1, ExatecanRelated Search:

CHLOROPHOSPHONAZO III Thiophanate-methyl Piroxicam Methyl salicylate Bensulfuron methyl Kresoxim-methyl Methyl 7,11-Diethyl-10-hydroxycaMptothecin Irinotecan Impurity 24 RPR121056A 4-Piperidinopiperidine 10-O-Acetyl SN-38 (+)-Camptothecin 12-Hydroxy Irinotecan 10-Hydroxycamptothecin 7-Ethylcamptothecin 7-Ethyl-10-(4-amino-1-piperidino)carbonyloxycamptothecin 7-Ethyl-10-hydroxycamptothecin

10H,13H-BENZO[DE]PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLINE-10,13-DIONE, 1-AMINO-9-ETHYL-5-FLUORO-1,2,3,9,12,15-HEXAHYDRO-9-HYDROXY-4-METHYL-, (1S,9S)-, MONOMETHANESULFONATE (SALT)

exatecan alideximer

(1S,9S)-1-Amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-10H,13H-benzo(de)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-10,13-dione

Exatecan

DX 8951

CS-147

Exatecan Impurity

10H,13H-Benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione, 1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (1S,9S)-

Irinotecan Impurity 36

1 Exatecan

Exatecan Base

(1S,9S)-1-amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-1,2,3,9,12,15-hexahydro-10H,13H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione

(1S,9S)-1-Amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-2,3,12,15-tetrahydrobenzo[de]pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-10,13(1H,9H)-dione

171335-80-1

1711335-80-1