Exatecan

Product Name: Exatecan
CAS No.: 171335-80-1
Chemical Name: Exatecan
Synonyms: exatecan alideximer;DX 8951;CS-147;Exatecan;1 Exatecan;Exatecan Base;Exatecan Impurity;Irinotecan Impurity 36;(1S,9S)-1-Amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-2,3,12,15-tetrahydrobenzo[de]pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-10,13(1H,9H)-dione;(1S,9S)-1-Amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-10H,13H-benzo(de)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-10,13-dione
CBNumber: CB91009566
Molecular Formula: C24H22FN3O4
Formula Weight: 435.45
MOL File: 171335-80-1.mol

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Exatecan Property

Boiling point:: 818.4±65.0 °C(Predicted)
Density: 1.53±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C,protect from light
solubility: Soluble in DMSO
pka: 11.19±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0005207
Product name: EXATECAN
Purity: 95.00%
Packaging: 5MG
Price: $1498.8
Updated: 2021/12/16

ChemScene

Product number: CS-2951
Product name: Exatecan
Packaging: 500mg
Price: $2480
Updated: 2021/12/16

ChemScene

Product number: CS-2951
Product name: Exatecan
Packaging: 100mg
Price: $2600
Updated: 2021/12/16

ChemScene

Product number: CS-2951
Product name: Exatecan
Packaging: 1g
Price: $4160
Updated: 2021/12/16

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Exatecan Chemical Properties,Usage,Production

Description

Exatecan is a hexacyclic chemical compound analogous to camptothecin and used as a payload in ADC research. Exatecan mesylate is used as an inhibitor of DNA topoisomerase I, which plays a key role in DNA replication, transcription, and recombination.

Definition

ChEBI: Exatecan is a pyranoindolizinoquinoline.

Biological Activity

Exatecan (DX-8951) is a DNA topoisomerase I (topoisomerase I) inhibitor with IC50 of 2.2 μM (0.975 μg/mL) for cancer research.

in vitro

Exatecan is a potent topoisomerase I inhibitor, with an IC 50 of 0.975 μg/mL. Exatecan Mesylate (DX-8951f) significantly inhibits the proliferation of several cancer cell lines, with mean GI 50 s of 2.02 ng/mL, 2.92 ng/mL, 1.53 ng/mL, and 0.877 ng/mL for breast cancer cells, colon cancer cells, stomach cancer cells and lung cancer cells, respectively. Exatecan Mesylate (DX-8951f) displays cytotoxic activities against PC-6, PC-6/SN2-5 cells, with mean GI 50 s of 0.186 and 0.395 ng/mL, respctively. Exatecan Mesylate (34 nM) stabilizes DNA-TopoI complexes in PC-6 and PC-6/SN2-5 cells.

in vivo

Exatecan Mesylate (DX-8951f, 3.325-50 mg/kg, i.v.) exhibits antitumor activities in the mice model bearing tumor cells, without toxic death. Exatecan Mesylate (15, 25 mg/kg, i.v.) hightly inhibits MIA-PaCa, BxPC-3 primary tumor growth in the MIA-PaCa-2 early-stage model and early-stage model of BxPC-3. Exatecan Mesylate (15, 25 mg/kg, i.v.) also significantly suppresses BxPC-3 lymphatic metastasis and completely eliminates lung metastasis in the BxPC-3 late-stage cancer model.

Exatecan Preparation Products And Raw materials

Raw materials

Preparation Products

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Exatecan Suppliers

China 102 India 3 United States 11 Global 116

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View Lastest Price from Exatecan manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: Exatecan 171335-80-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

Zhuozhou Wenxi import and Export Co., Ltd

Product: Exatecan 171335-80-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Exatecan 171335-80-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

171335-80-1, ExatecanRelated Search:

CHLOROPHOSPHONAZO III Thiophanate-methyl Piroxicam Methyl salicylate Bensulfuron methyl Kresoxim-methyl Methyl 7,11-Diethyl-10-hydroxycaMptothecin Irinotecan Impurity 24 RPR121056A 4-Piperidinopiperidine 10-O-Acetyl SN-38 (+)-Camptothecin 12-Hydroxy Irinotecan 10-Hydroxycamptothecin 7-Ethylcamptothecin 7-Ethyl-10-(4-amino-1-piperidino)carbonyloxycamptothecin 7-Ethyl-10-hydroxycamptothecin

10H,13H-BENZO[DE]PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLINE-10,13-DIONE, 1-AMINO-9-ETHYL-5-FLUORO-1,2,3,9,12,15-HEXAHYDRO-9-HYDROXY-4-METHYL-, (1S,9S)-, MONOMETHANESULFONATE (SALT)

exatecan alideximer

(1S,9S)-1-Amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-10H,13H-benzo(de)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-10,13-dione

Exatecan

DX 8951

CS-147

Exatecan Impurity

10H,13H-Benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione, 1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (1S,9S)-

Irinotecan Impurity 36

1 Exatecan

Exatecan Base

(1S,9S)-1-amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-1,2,3,9,12,15-hexahydro-10H,13H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione

(1S,9S)-1-Amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-2,3,12,15-tetrahydrobenzo[de]pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-10,13(1H,9H)-dione

171335-80-1

1711335-80-1