Chemical Structure Application
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neopentyl glycol

Chemical Structure Application
Product Name
neopentyl glycol
CAS No.
126-30-7
Chemical Name
neopentyl glycol
Synonyms
NEOPENTYL GLYCOL;2,2-Dimethylpropane-1,3-diol;1,3-Dihydroxy-2,2-dimethylpropane;NEOPENTYL GLYCO;Neol;NPG Glycol;2,2-Dimethyl-1;NEOPENTYLENE GLYCOL;2,2-BIS(HYDROXYMETHYL)PROPANE;NEOL(R)
CBNumber
CB9111688
Molecular Formula
C5H12O2
Formula Weight
104.15
MOL File
126-30-7.mol
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neopentyl glycol Property

Melting point:
126-128 °C
Boiling point:
208 °C
Density 
1.06
vapor density 
3.6 (vs air)
vapor pressure 
<0.8 mm Hg ( 20 °C)
refractive index 
1.4406 (estimate)
Flash point:
107 °C
storage temp. 
Inert atmosphere,Room Temperature
solubility 
830g/l
pka
14.57±0.10(Predicted)
form 
Crystalline Chunks
color 
White
explosive limit
1.34%, 149°F
Water Solubility 
830 g/L (20 ºC)
Sensitive 
Hygroscopic
Merck 
14,6458
BRN 
605291
Stability:
Stable. Incompatible with strong oxidizing agents, acetic anhydride, acid chlorides, moisture. Combustible.
LogP
-0.15 at 25℃
CAS DataBase Reference
126-30-7(CAS DataBase Reference)
NIST Chemistry Reference
1,3-Propanediol, 2,2-dimethyl-(126-30-7)
EPA Substance Registry System
Neopentyl glycol (126-30-7)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-36-41
Safety Statements 
26-36-39
WGK Germany 
1
RTECS 
TY5775000
F 
3
Autoignition Temperature
750 °F
TSCA 
Yes
HS Code 
29053990
Hazardous Substances Data
126-30-7(Hazardous Substances Data)
Toxicity
rat,LCLo,inhalation,39000ppm/6H (39000ppm),Kodak Company Reports. Vol. 21MAY1971,
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
538256
Product name
2,2-Dimethyl-1,3-propanediol
Purity
99%
Packaging
25g
Price
$17.04
Updated
2024/03/01
Sigma-Aldrich
Product number
538256
Product name
2,2-Dimethyl-1,3-propanediol
Purity
99%
Packaging
3kg
Price
$95.8
Updated
2024/03/01
Sigma-Aldrich
Product number
52488
Product name
2,2-Dimethyl-1,3-propanediol
Purity
analytical standard
Packaging
100MG
Price
$69
Updated
2022/05/15
TCI Chemical
Product number
D0791
Product name
2,2-Dimethyl-1,3-propanediol
Purity
>98.0%(GC)
Packaging
25g
Price
$18
Updated
2024/03/01
TCI Chemical
Product number
D0791
Product name
2,2-Dimethyl-1,3-propanediol
Purity
>98.0%(GC)
Packaging
500g
Price
$30
Updated
2024/03/01
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neopentyl glycol Chemical Properties,Usage,Production

Chemical Structure

The chemical formula for Neopentyl glycol (NPG) is C5H12O2, and it is a propane-1,3-diol carrying two methyl groups at position 2.Neopentyl glycol is soluble in water, benzene, chloroform, and very soluble in ethanol and diethyl ether. Neopentylglycol (NPG) is a unique polyalcohol offering superior performance advantages in many end-use applications due to its high chemical and thermal stability. It is a unique diol offering superior performance advantages in many end-use applications. These advantages are derived from its chemical structure. The location of the hydroxyl groups on primary carbon atoms allows rapid esterification. Additionally, the two methyl groups, instead of the usual two hydrogen atoms, on the alpha carbon atom are responsible for the high chemical and thermal stability of Neopentylglycol and its derivatives.

Application

Neopentyl glycol is used in the synthesis of polyesters, paints, lubricants, and plasticizers. When used in the manufacture of polyesters, it enhances the stability of the product towards heat, light, and water. By esterification reaction with fatty or carboxylic acids, synthetic lubricating esters with reduced potential for oxidation or hydrolysis, compared to natural esters, can be produced. NPG is used primarily in base resins for coatings. In powder coating formulations, Neopentylglycol offers the additional advantage of providing small differences between the glass transition temperature and melting point. Important areas of application include general metal, appliance, metal furniture, automotive and machinery coatings. Important uses are also found in hydraulic fluids, synthetic lubricant oils, greases, metalworking fluids and aircraft engine lubricants. Other outlets include textiles, pharmaceuticals, pesticides, plasticizers and petroleum.
High quality NPG is shipped as flake, molten and slurry. The high-quality NPG is the component in polyester resins for industrial coatings and fiberglass-reinforced plastics applications, and most polyester resin formulations contain NPG as the sole glycol component, or it is used in conjunction with a modifying glycol to achieve desired properties. NPG is also used in polyester polyols for polyurethane coatings for the automotive, industrial maintenance, transportation, and aerospace markets.

Uses

NPG Glycol is used in the synthesis of tetraphenylporphyrins. Also used in the synthesis of Bryostatin 2, a protein kinase modulator.

Uses

In the manufacture of plasticizers, polyesters, as modifier of alkyd resins.

Uses

2,2-Dimethyl-1,3-propanediol may be used in the synthesis of:

  • 2,2-dimethyl-1,3-propanediol cyclic phosphorochloridate
  • 2,2-dimethyl-1,3-propanediol cyclic phenylphosphonate
  • [1′,3′-(2′,2′-dimethylpropylene)]-2-iodo-3-octyl-5-thienylboronate
  • cyclic carbonate
  • 2,2-dimethyl-1,3-propanediol bis(cyclic-2,2-dimethyltrimethylene phosphite)

Definition

ChEBI: Neopentyl glycol is a propane-1,3-diol carrying two methyl groups at position 2.

Preparation

3-hydroxy-2,2-dimethylpropanal) could be reduced to neopentyl glyco. Hydroxypivaldehyde can be reduced either by a crossed Cannizzaro reaction with equimolar amounts of formaldehyde and a base, or by catalytic hydrogenation. If inorganic bases such as potassium carbonate or sodium hydroxide are used as catalysts, satisfactory yields (ca. 80 %) of neopentyl glycol can be obtained only with an excess of isobutyraldehyde. Tertiary amines are also used as catalysts for the aldol addition. Catalytic transfer hydrogenation of the aldol intermediate is also possible using formate salts as hydrogen source. After fractional distillation a very good yield of high-purity neopentyl glycol is obtained.

benefits

Neopentyl Glycol is known for its skin conditioning properties. This means it helps to maintain the skin in good condition.

General Description

White crystalline solid. Melting point 130°C.

Air & Water Reactions

Soluble in water.

Reactivity Profile

2,2-Dimethyl-1,3-propanediol may generate toxic gases in combination of with alkali metals, nitrides, and strong reducing agents. Reacts with inorganic acids and carboxylic acids to form esters plus water. Converted to aldehydes or acids by oxidizing agents. May initiate the polymerization of isocyanates and epoxides.
In addition to the reactions typical of primary alcohols, such as ester, ether, and carbamate (urethane) formation, 1,3-diols give six-membered cyclic derivatives with carbonyl compounds, carbonates, phosphites, sulfifites, and borates.

Health Hazard

May be harmful by ingestion or skin absorption. Causes eye and skin irritation. Material is irritating to mucous membrane and upper respiratory tract. INHALATION: Call for medical aid. Remove to fresh air. If breathing has stopped, give artificial respiration. If breathing is difficult, give oxygen.

Fire Hazard

Special Hazards of Combustion Products: Emits toxic fumes under fire condition.

Solubility in water

Neopentyl glycol is soluble in water, alcohols, and ketones, moderately soluble in hot aromatic solvents, such as benzene and toluene, and relatively insoluble in aliphatic and cycloaliphatic solvents.

storage

During storage, higher temperatures and stacking pressures can lead to caking of the lower stack layers. As a hygroscopic material, 2,2-Dimethyl-1,3-propanediol must be stored dry. The product is also sold as 90 % aqueous solution, which should be stored at 55 – 60 ℃ to avoid precipitation, and as a 100 % melt.

Purification Methods

Crystallise the diol from *benzene or acetone/water (1:1). [Beilstein 1 IV 2551.]

neopentyl glycol Preparation Products And Raw materials

Raw materials

Pivaldehyde Sodium formate Isobutyraldehyde

Preparation Products

2-METHOXY-6-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE Unsaturated polyester resin 5-(TRIFLUOROMETHYL)-2-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE 2-CHLORO-6-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE Ibuprofen 3-METHOXY-2-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE 4-(TRIFLUOROMETHYL)-2-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE 2-(TRIFLUOROMETHYL)-6-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE 2-CYANO-5-BROMOPHENYLBORONIC ACID PINACOL ESTER Sodium formate 2-BROMO-6-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE ISOQUINOLINE-4-BORONIC ACID 2,2-DIMETHYLPROPANEDIOL-1,3 CYCLIC ESTER Triethylene glycol dimethacrylate 4-CHLORO-2-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE 3-FLUORO-2-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE
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View Lastest Price from neopentyl glycol manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
2,2-Dimethyl-1,3-propanediol 126-30-7
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-13
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
neopentyl glycol 126-30-7
Price
US $70.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-05-27
Hebei Longbang Technology Co., Ltd
Product
2,2-Dimethyl-1,3-propanediol 126-30-7
Price
US $6.00/kg
Min. Order
1kg
Purity
More than 99%
Supply Ability
2000KG/Month
Release date
2024-05-11

126-30-7, neopentyl glycolRelated Search:

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  • 2,2-DIMETHYL-1,3-PROPANEDIOL 99.5+%
  • neopentyl glycol(2,2-dimethyl-1,3-propanedil)
  • 2,2-Dimethyl-1,3-propanediol,NPG Glycol, Neopentylglycol
  • Neopentyl Glycol (Slurry and Flake)
  • 2,2-DiMethyl-1,3-propanediol, 99% 25GR
  • 2,2-DiMethyl-1,3-propanediol, 99% 500GR
  • 2,2-Bis(hydroxymethyl)propane 2,2-Dihydroxy-2,2-dimethylpropane Neopentyl Glycol
  • 2,2-DIMETHYL-1,3-PROPANEDIOL FOR SYNTHES
  • Neopentyl glycol (NPG)
  • 2,2-DiMethyl-1,3-propanediol 99%
  • 2,2-DiMethyl-1,3-propanediol, 99.5%, 99.5%
  • 2,2-dimethyl-3-propanediol
  • 2,2-Dimethylpropane-1,3-diol
  • 2,2-dimethyltrimethyleneglycol
  • 3-Propanediol,2,2-dimethyl-1
  • Dimethylolpropane
  • Hydroxypivalyl alcohol
  • hydroxypivalylalcohol
  • Neol
  • Neopentanediol
  • NPG Glycol
  • DIMETHYLTRIMETHYLENE GLYCOL
  • NEOPENTYLENE GLYCOL
  • NEOPENTYL GLYCOL
  • NEOL(R)
  • 2,2-BIS(HYDROXYMETHYL)PROPANE
  • 2,2-DIHYDROXY-2,2-DIMETHYLPROPANE
  • 2,2-DIMETHYL-1,3-PROPANEDIOL
  • 2,2-Dimethyl-1
  • Neopentylglycol flakes
  • 2,2-Dimethyl-1,3-propanediol(NPG Glycol)
  • 2,2-Dimethyl-1,3-propanediol, 99.5%, for synthesis
  • 2,2-Dimethyl-1,3-propanediol, 99%, for synthesis
  • 2,2-Dimethyl-1,3-propanediol &gt
  • -1,3-propanedioL
  • 2,2-Dimethyl-1,3-propanediol ISO 9001：2015 REACH
  • Neopentyl glycol CAS126-30-7
  • Neopentyl Glycol Solid C5h12o2 126-30-7 Npg Neopentyl Glycol
  • 22,2-Dimethyl-1,3-propanediol
  • Neopentyl Glycol 98% For Synthesis
  • 126-30-7
  • CH32CCH2OH2
  • 126307
  • HOCD2CCD32CD2OH
  • Polyols
  • Oxygen Compounds