3-Amino-4-methoxybenzoic acid
- Product Name
- 3-Amino-4-methoxybenzoic acid
- CAS No.
- 2840-26-8
- Chemical Name
- 3-Amino-4-methoxybenzoic acid
- Synonyms
- 3-Aminoanisic acid;Amino-p-Anisic Acid;3-AMINO-4-ANISIC ACID;3-Amino-p-anisic acid;LABOTEST-BB LT01138583;5-Carboxy-2-methoxyaniline;3-AMINO-METHOXY BENZOIC ACID;3-amino-4-methoxy-benzoicaci;3-AMINO-4-METHOXYBENZOIC ACID;3-Amino-4-methoxylbenzoic acid
- CBNumber
- CB9122628
- Molecular Formula
- C8H9NO3
- Formula Weight
- 167.16
- MOL File
- 2840-26-8.mol
3-Amino-4-methoxybenzoic acid Property
- Melting point:
- 208-210 °C(lit.)
- Boiling point:
- 295.73°C (rough estimate)
- Density
- 1.2917 (rough estimate)
- refractive index
- 1.5570 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- powder to crystal
- pka
- 4.69±0.10(Predicted)
- color
- White to Gray to Brown
- Water Solubility
- Soluble in water.
- InChI
- InChI=1S/C8H9NO3/c1-12-7-3-2-5(8(10)11)4-6(7)9/h2-4H,9H2,1H3,(H,10,11)
- InChIKey
- FDGAEAYZQQCBRN-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC=C(OC)C(N)=C1
- CAS DataBase Reference
- 2840-26-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-37/38-36
- Safety Statements
- 26-37/39
- WGK Germany
- 3
- RTECS
- DG2872000
- HS Code
- 29225090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- A1955
- Product name
- 3-Amino-4-methoxybenzoic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $106
- Updated
- 2025/07/31
- Product number
- A1955
- Product name
- 3-Amino-4-methoxybenzoic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $424
- Updated
- 2025/07/31
- Product number
- A612235
- Product name
- 3-Amino-4-methoxybenzoic Acid
- Packaging
- 100g
- Price
- $360
- Updated
- 2021/12/16
- Product number
- A612235
- Product name
- 3-Amino-4-methoxybenzoic Acid
- Packaging
- 25g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- JK128840
- Product name
- 3-Amino-4-methoxybenzoic Acid
- Purity
- 98%
- Packaging
- 25g
- Price
- $125
- Updated
- 2021/12/16
3-Amino-4-methoxybenzoic acid Chemical Properties,Usage,Production
Chemical Properties
White to light yellow crystal powder
Uses
It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.
Uses
3-Amino-4-methoxybenzoic Acid is a general reactant/reagent used in the synthesis of VEGFR-2 inhibitors. Also used in the preparation of dihydroisoquinoline compounds as tubulin polymerization inhibitors.
Synthesis
110-53-2
89-41-8
2840-26-8
The general procedure for the synthesis of 3-amino-4-methoxybenzoic acid from 1-bromopentane and 4-methoxy-3-nitrobenzoic acid was as follows: 4-methoxy-3-nitrobenzoic acid (5 g, 25.4 mmol), DMF (30 ml), potassium carbonate (5.53 g, 40 mmol) and 1-bromopentane (4 ml, 32.3 mmol) were mixed at 100 °C and The reaction was stirred for 1.5 hours. After completion of the reaction, the reaction mixture was filtered to remove the inorganic salts, followed by evaporation of DMF under reduced pressure. ethyl acetate (100 ml) was added to the residue, the mixture was washed three times with saturated brine (30 ml) and dried with anhydrous magnesium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure. To the resulting residue was added ethanol (150 ml) and 10% palladium-carbon catalyst (0.5 g) and stirred in a stream of hydrogen for 5.5 hours at room temperature. At the end of the reaction, the palladium-carbon catalyst was removed by filtration and the filtrate was concentrated under reduced pressure. Finally, the residue was purified by column chromatography (eluent: hexane/ethyl acetate = 3/1) to afford 3-amino-4-methoxybenzoic acid (5.98 g, 99% yield, two-step reaction) as colorless crystals. The product was confirmed by 1H-NMR (CDCl3) and FABMS characterization.
References
[1] Patent: US6017919, 2000, A
3-Amino-4-methoxybenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
3-Amino-4-methoxybenzoic acid Suppliers
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View Lastest Price from 3-Amino-4-methoxybenzoic acid manufacturers
- Product
- 3-Amino-4-methoxybenzoic acid 2840-26-8
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 20kg/month
- Release date
- 2019-11-05
- Product
- 3-Amino-4-methoxybenzoic acid 2840-26-8
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- as request
- Release date
- 2018-12-23