ChemicalBook > CAS DataBase List > Cucurbitacin IIb

Cucurbitacin IIb

Product Name: Cucurbitacin IIb
CAS No.: 50298-90-3
Chemical Name: Cucurbitacin IIb
Synonyms: Hemslecin B;Cucurbitacin Ⅱb;cucuritacin IIB;Cucurbitacin Ⅱb;Cucurbitacin IIb;23,24-Dihydrocucurbitacin F;Cucurbitacin IIb, 10 mM in DMSO;(10α)-2β,3α,16α,20,25-Pentahydroxy-9β-methyl-19-norlanost-5-ene-11,22-dione;19-Norlanost-5-ene-11,22-dione, 2,3,16,20,25-pentahydroxy-9-methyl-, (2β,3α,9β,10α,16α)-;(1S,2S,4R,9β,16α,17ξ)-1,2,16,20,25-pentahydroxy-9,10,14-trimethyl-4,9-cyclo-9,10-secocholest-5-ene-11,22-dione
CBNumber: CB91267775
Molecular Formula: C30H48O7
Formula Weight: 520.7
MOL File: 50298-90-3.mol

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Cucurbitacin IIb Property

Melting point:: 158-159℃
Boiling point:: 668.4±55.0 °C(Predicted)
Density: 1.22±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.: 2-8°C
pka: 12.86±0.29(Predicted)
form: Solid
color: White to off-white
InChIKey: VVBWBGOEAVGFTN-JCJZBDFNNA-N

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: 300125
Product name: Cucurbitacin IIb
Packaging: 10mg
Price: $433
Updated: 2021/12/16

ApexBio Technology

Product number: N2200
Product name: Cucurbitacin B
Packaging: 20mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0018308
Product name: CucurbitacinIIb
Purity: >99.0%
Packaging: 10mg
Price: $457
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb259180
Product name: Cucurbitacin IIb
Purity: 98%
Packaging: 10mg
Price: $472.6
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PXT0005262
Product name: DIHYDROCUCURBITACIN F
Purity: 95.00%
Packaging: 5MG
Price: $500.15
Updated: 2021/12/16

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Cucurbitacin IIb Chemical Properties,Usage,Production

Description

Cucurbitacin IIa and cucurbitacin IIb are the characteristic chemical constituents of the hemsleya. Hemsleyadinum are extracted from the Cucurbitaceae, Chrysanthemum, and Hemsleya, which have the function of clearing heat and removing toxicity and antisepsis and anti-inflammation. There are 31 species of Hemsleya in the world, most of which are distributed in China’s Yunnan, Guizhou, and Sichuan provinces, besides the 2 species distributed in India and Vietnam. The main species are H. emiensis, H. pengxianensis, H. amabilis, H. dolichocarpa, H. graciliflora, and H. gigantha . Hemsleya plants are commonly used as Chinese herbal medicines.

Chemical Properties

White powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from the tuber of snow twig.

Physical properties

Appearance: rhombohedral or flaky crystals, Solubility: soluble in methanol, ethanol, and acetone, slightly soluble in chloroform, insoluble in water.

History

Hemsleyadinum and hemsloside inhibit Shigella dysenteriae, Salmonella typhimurium, and Salmonella choleraesuis in?vitro. Intravenous injection of cucurbitacin IIa has mild antipyretic effect caused by intraperitoneal injection of typhoid and paratyphoid bacteria but invalid to those with normal body temperature and nonbacterial fever. Xuedansu tablets have significant antitussive effect and show inhibitory effect against p-xylene-induced mouse ear swelling and carrageenaninduced rat toe swelling. Cucurbitacin IIa and cucurbitacin IIb also have anti-HIV-1 activity, which plays a vital role in HIV-1 virus infection . Hemsleyadinum has significant protective effect against acute liver injury caused by CCl4, especially at the high dosage .

Indications

Its dosage forms and indications are available at the Pharmacopoeia of the People’s Republic of China (1977). The current clinical use of hemsleyadinum includes tablets and capsules, which are suitable for bacillary dysentery, enteritis, bronchitis, and acute tonsillitis.

Pharmacology

The main active ingredient in Cucurbitaceae plants is cucurbitacins, and cucurbitacin IIa and IIb have been used in clinics. Their indications include bacillary dysentery, enteritis, bronchitis, acute tonsillitis, and so on. Cucurbitacin IIa also has anticancer effect . Cucurbitacin IIa (25–100?μM) dose-dependently inhibits proliferation of human lung adenocarcinoma A549 and mouse adenocarcinoma. It blocks the G0/G1 and S phase of A549 cells and thus promotes cell apoptosis . The anticancer mechanism of cucurbitacin IIa is to prevent cancer cell spreading by destroying cytoskeleton of actin and leading to PARP-induced apoptosis by inhibiting production of downstream surviving of JAK/STAT3.

Clinical Use

At present, hemsleyadinum mainly are used as antibacterial and anti-inflammatory drugs, suitable for treatment of upper respiratory tract infection, acute tonsillitis, mumps, pharyngitis, acute and chronic bronchitis, pneumonia etc. Generally speaking, hemsleyadinum and its preparations have less side effects, such as diarrhea, abdominal pain, and other gastrointestinal reactions.

Cucurbitacin IIb Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Cucurbitacin IIb manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Cucurbitacin IIb 50298-90-3
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-03-12

Shaanxi Dideu Medichem Co. Ltd

Product: Cucurbitacin IIb 50298-90-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 800 tons
Release date: 2020-05-01

Career Henan Chemical Co

Product: Cucurbitacin IIb 50298-90-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 25kg
Release date: 2019-07-12

50298-90-3, Cucurbitacin IIbRelated Search:

CUCURBITACIN IIA cucurbitacins Arbutin Corydaline Lycorine hydrochloride SINOMENINE HYDROCHLORIDE SECO-ISOLARICIRESINOL DIGLUCOSIDE Betaine hydrochloride STACHYDRINE HYDROCHLORIDE 4-Guanidinobutyl 4-hydroxy-3,5-diMethoxybenzoate hydrochloride Berberine hydrochloride SANGUINARINE Ligustrazine Hydrochloride JATRORRHIZINE HCL(RG) Coptisine chloride CUCURBITACIN I Cucurbitacin IIb (Z)-6-HENICOSEN-11-ONE

Cucurbitacin IIb

(10α)-2β,3α,16α,20,25-Pentahydroxy-9β-methyl-19-norlanost-5-ene-11,22-dione

23,24-Dihydrocucurbitacin F

Cucurbitacin Ⅱb

(1S,2S,4R,9β,16α,17ξ)-1,2,16,20,25-pentahydroxy-9,10,14-trimethyl-4,9-cyclo-9,10-secocholest-5-ene-11,22-dione

Hemslecin B

19-Norlanost-5-ene-11,22-dione, 2,3,16,20,25-pentahydroxy-9-methyl-, (2β,3α,9β,10α,16α)-

(2S,3S,8S,9R,10R,13R,14S,16R,17R)-17-[(2R)-2,6-dihydroxy-6-methyl-3-oxoheptan-2-yl]-2,3,16-trihydroxy-4,4,9,13,14-pentamethyl-1,2,3,7,8,10,12,15,16,17-decahydrocyclopenta[a]phenanthren-11-one

cucuritacin IIB

(2S,3S,8S,9R,10R,13R,14S,16R,17R)-17-((R)-2,6-Dihydroxy-6-methyl-3-oxoheptan-2-yl)-2,3,16-trihydroxy-4,4,9,13,14-pentamethyl-1,2,3,4,7,8,9,10,12,13,14,15,16,17-tetradecahydro-11H-cyclopenta[a]phenanthren-11-one

Cucurbitacin IIb, 10 mM in DMSO

Cucurbitacin Ⅱb

50298-90-3

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract