ChemicalBook > CAS DataBase List > 1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester(9CI)

1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester(9CI)

Product Name
1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester(9CI)
CAS No.
190141-99-2
Chemical Name
1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester(9CI)
Synonyms
1-BOC-3-AMINO-4-HYDROXY-PYRROLIDINE;tert-Butyl 3-aMino-4-hydroxypyrrolidine-1-carboxylate;tert-Butyl 3-amino-4-hydroxy-1-pyrrolidinecarboxylate;2-Methyl-2-propanyl 3-amino-4-hydroxy-1-pyrrolidinecarboxylate;1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethyle...;3-Amino-4-hydroxy-1-pyrrolidinecarboxylic acid tert-butyl ester;tert-butyl 3-amino-4-hydroxy-pyrrolidine-1-carboxylate - [B84159];1-Pyrrolidinecarboxylic acid, 3-aMino-4-hydroxy-, 1,1-diMethylethyl ester;1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester(9CI);[trans-]-3-amino-4-hydroxy-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester
CBNumber
CB91271716
Molecular Formula
C9H18N2O3
Formula Weight
202.25
MOL File
190141-99-2.mol
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1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester(9CI) Property

Boiling point:
309℃
Density 
1.179
Flash point:
141℃
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
14.36±0.40(Predicted)
Appearance
White to off-white Solid
InChI
InChI=1S/C9H18N2O3/c1-9(2,3)14-8(13)11-4-6(10)7(12)5-11/h6-7,12H,4-5,10H2,1-3H3
InChIKey
MOZOQDNRVPHFOO-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CC(O)C(N)C1
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
B814488
Product name
tert-Butyl3-amino-4-hydroxypyrrolidine-1-carboxylate
Packaging
100mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB144052
Product name
tert-Butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate
Packaging
250mg
Price
$85
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB144052
Product name
tert-Butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate
Packaging
500mg
Price
$145
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB144052
Product name
tert-Butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate
Packaging
1g
Price
$256
Updated
2021/12/16
ChemScene
Product number
CS-0036146
Product name
tert-Butyl3-amino-4-hydroxypyrrolidine-1-carboxylate
Purity
>97.0%
Packaging
5g
Price
$285
Updated
2021/12/16
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1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester(9CI) Chemical Properties,Usage,Production

Synthesis

114214-49-2

190141-99-2

The general procedure for the synthesis of tert-butyl 3-amino-4-hydroxy-1-pyrrolidinecarboxylate from 3-N-tert-butoxycarbonyl-6-oxa-3-azabicyclo[3.1.0]hexane is as follows: tert-butyl 6-oxa-3-azabicyclo[3.1.0]hexane-3-carboxylate (20 g, 0.11 mol) was mixed with ammonia (200 mL) and heated under reflux conditions to react Overnight. After completion of the reaction, the reaction mixture was concentrated in vacuum to afford the target product tert-butyl 3-amino-4-hydroxypyrrolidine-1-carboxylate (21 g, 96% yield) as a light yellow oil.1H NMR (400 MHz, CDCl3) data were as follows: δ 3.98-3.97 (m, 1H), 3.75-3.61 (m, 2H), 3.36- 3.22 (m, 2H), 3.08-3.17 (m, 1H), 1.45 (s, 9H).

References

[1] Patent: WO2010/114971, 2010, A1. Location in patent: Page/Page column 153
[2] Bioorganic and Medicinal Chemistry Letters, 1998, vol. 8, # 3, p. 221 - 226
[3] Patent: WO2004/108661, 2004, A1. Location in patent: Page/Page column 48-49
[4] Patent: WO2005/28454, 2005, A1. Location in patent: Page/Page column 50-51
[5] Patent: WO2004/838, 2003, A1. Location in patent: Page 71

1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester(9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester(9CI) manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd
Product
1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester(9CI) 190141-99-2
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
Customise
Release date
2025-10-04

190141-99-2, 1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethylethylester(9CI)Related Search:

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  • 3-Amino-4-Hydroxy-Pyrrolidine-1-Carboxylic Acid Tert-Butyl Ester(Mixture Of Cis&Trans)
  • 1-BOC-3-AMINO-4-HYDROXY-PYRROLIDINE
  • tert-Butyl 3-aMino-4-hydroxypyrrolidine-1-carboxylate
  • 1-Pyrrolidinecarboxylic acid, 3-aMino-4-hydroxy-, 1,1-diMethylethyl ester
  • 3-Amino-4-hydroxy-1-pyrrolidinecarboxylic acid tert-butyl ester
  • tert-Butyl 3-amino-4-hydroxy-1-pyrrolidinecarboxylate
  • [trans-]-3-amino-4-hydroxy-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester
  • 1-Pyrrolidinecarboxylicacid,3-amino-4-hydroxy-,1,1-dimethyle...
  • tert-butyl 3-amino-4-hydroxy-pyrrolidine-1-carboxylate - [B84159]
  • 190141-99-2
  • AMINOACID