3-Iodopyridine
- Product Name
- 3-Iodopyridine
- CAS No.
- 1120-90-7
- Chemical Name
- 3-Iodopyridine
- Synonyms
- 3-Iodo Pyrdine;3-lodopyridine;3-IODOPYRIDINE;3-Pyridyl iodide;3-Iodopyridine>Pyridine, 3-iodo-;3-Iodopyridine,99%;3-Iodopyridine 98%;3-Iodopyridine ,98%;3-IODOPYRAZOLOPYRIDINE
- CBNumber
- CB9129854
- Molecular Formula
- C5H4IN
- Formula Weight
- 205
- MOL File
- 1120-90-7.mol
3-Iodopyridine Property
- Melting point:
- 53-56 °C (lit.)
- Boiling point:
- 90-92°C 14mm
- Density
- 1.9668 (estimate)
- Flash point:
- 224 °F
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- powder to crystal
- pka
- pK1:3.25(＋1) (25°C)
- color
- White to Light yellow to Light red
- Sensitive
- Light Sensitive
- BRN
- 106059
- CAS DataBase Reference
- 1120-90-7(CAS DataBase Reference)
- NIST Chemistry Reference
- Pyridine, 3-iodo-(1120-90-7)
Safety
- Hazard Codes
- Xi,T
- Risk Statements
- 36/37/38-23/24/25
- Safety Statements
- 26-36-45-36/37/39
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- IRRITANT, LIGHT SENSITIVE
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 539368
- Product name
- 3-Iodopyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $47.6
- Updated
- 2025/07/31
- Product number
- 539368
- Product name
- 3-Iodopyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $93.9
- Updated
- 2025/07/31
- Product number
- I0568
- Product name
- 3-Iodopyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $75
- Updated
- 2025/07/31
- Product number
- I0568
- Product name
- 3-Iodopyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $226
- Updated
- 2025/07/31
- Product number
- I719435
- Product name
- 3-Iodopyridine
- Packaging
- 2.5g
- Price
- $75
- Updated
- 2021/12/16
3-Iodopyridine Chemical Properties,Usage,Production
Chemical Properties
light beige crystalline powder
Uses
3-Iodopyridine may be used to synthesize following pyridine alkaloids:
- theonelladins C
- theonelladins D
- niphatesine C
- xestamine D
Synthesis
626-55-1
1120-90-7
The general procedure for the synthesis of 3-iodopyridine from 3-bromopyridine is as follows: the aromatic Finkelstein reaction is used. Since copper(I) iodide is sensitive to moisture and oxygen, the reaction needs to be carried out under argon protection using the standard Schlenk technique. The procedure is as follows: to a two-necked pear-shaped flask equipped with a reflux condenser is added 3-bromopyridine (as the aryl bromine feedstock), NaI (2 equiv. per bromine exchanged), and CuI (5 mol% per bromine exchanged). N,N'-dimethylethylenediamine (L1) or N,N'-dimethyl-1,2-cyclohexanediamine (L2) (10 mol% used per bromine exchange) and anhydrous 1,4-dioxane (0.5 mL used per 1 mmol NaI) were subsequently added. The resulting suspension was heated to 110°C and maintained for 18 hours. After completion of the reaction, it was cooled to room temperature and the mixture was poured into a 25% aqueous NH3 solution. The blue solution was diluted to twice the original volume with H2O and extracted three times with CH2Cl2. For the case of 2,2'-bipyridine, the combined organic phases were additionally washed with aqueous EDTA; otherwise, the combined organic phases were simply washed with brine and dried with MgSO4. Subsequently, the solvent is removed by distillation under reduced pressure to give pure 3-iodopyridine. If necessary, the crude product can be further purified by column chromatography or recrystallization.
References
[1] Synthesis (Germany), 2014, vol. 46, # 8, p. 1085 - 1090
[2] Tetrahedron Letters, 1999, vol. 40, # 23, p. 4339 - 4342
[3] Tetrahedron, 2000, vol. 56, # 10, p. 1349 - 1360
[4] Chemistry - A European Journal, 2010, vol. 16, # 41, p. 12425 - 12433
[5] Chemical & Pharmaceutical Bulletin, 1982, vol. 30, # 5, p. 1731 - 1737
3-Iodopyridine Preparation Products And Raw materials
Raw materials
Preparation Products
3-Iodopyridine Suppliers
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- Country
- Belgium
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- 3824
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View Lastest Price from 3-Iodopyridine manufacturers
- Product
- 3-Iodopyridine 1120-90-7
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2021-10-15
- Product
- 3-Iodopyridine 1120-90-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-01
- Product
- 3-Iodopyridine 1120-90-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11