SU 6668

ChemicalBook > CAS DataBase List > SU 6668

Product Name: SU 6668
CAS No.: 210644-62-5
Chemical Name: SU 6668
Synonyms: SU 6668;(Z)-SU6668;(Z)-TSU-68;(Z)-Orantinib;(Z)-Orantinib/SU6668/TSU-68);PDGFR Tyrosine Kinase Inhibitor VI, SU6668;PDGFR Tyrosine Kinase Inhibitor VI, SU6668 - CAS 210644-62-5 - Calbiochem;3-[2,4-dimethyl-5-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoicacid;3-(2,4-Dimethyl-5-{[(3Z)-2-oxo-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)propanoic acid;3-(2,4-Dimethyl-5-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrol-3-yl)-propionic acid
CBNumber: CB91312244
Molecular Formula: C18H18N2O3
Formula Weight: 310.35
MOL File: 210644-62-5.mol

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SU 6668 Property

storage temp.: +2C to +8C
solubility: DMSO : 50 mg/mL (161.11 mM; Need ultrasonic)
form: Dark yellow solid
color: Orange to red

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS023028
Product name: 2,4-Dimethyl-5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-pyrrole-3-propanoic acid
Packaging: 100MG
Price: $308
Updated: 2023/01/07

Tocris

Product number: 3335
Product name: SU6668
Purity: ≥99%(HPLC)
Packaging: 10
Price: $208
Updated: 2021/12/16

TRC

Product number: D457088
Product name: (Z)-3-(2,4-Dimethyl-5-((2-oxoindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoicacid(SU-6668)
Packaging: 5mg
Price: $90
Updated: 2021/12/16

Usbiological

Product number: 256776
Product name: SU 6668
Packaging: 10mg
Price: $466
Updated: 2021/12/16

Matrix Scientific

Product number: 132613
Product name: (Z)-3-(2,4-Dimethyl-5-((2-oxoindolin-3-ylidene)-methyl)-1H-pyrrol-3-yl)propanoicacid
Purity: 97%
Packaging: 250mg
Price: $537
Updated: 2021/12/16

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SU 6668 Chemical Properties,Usage,Production

Uses

PDGFR Tyrosine Kinase Inhibitor VI, SU6668 is a potent ATP-competitive inhibitor against tyrosine kinases.

General Description

A cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFRβ, VEGFR2 (Flk-1/KDR), FGFR1 activity in vitro (IC₅₀ = 0.01, 0.1, 3.9, and 3.8 μM, respectively) and PDGF/VEGF/bFGF-mediated angiogenesis and tumor development in vivo. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target ser/thr kinases Aurora A, Aurora B, TBK1 (NAK/T2K), and AMPK (IC₅₀ = 0.85, 0.047, 1.4, and 1.8 μM, respectively), as well as non-receptor TKs Lyn and Yes (IC₅₀ = 4.3 and 5.8 μM, respectively).

SU 6668 Preparation Products And Raw materials

Raw materials

Preparation Products

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SU 6668 Suppliers

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210644-62-5, SU 6668Related Search:

3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione INCB39110 X-376 Filgotinib Decernotinib Masitinib Lestaurtinib CAL-101 PLX3397 (Pexidartinib) CO-1686 Momelotinib 790299-79-5 AZD-6244 ARRY-334543 Dovitinib Volitinib

SU 6668

3-(2,4-Dimethyl-5-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrol-3-yl)-propionic acid

1H-Pyrrole-3-propanoic acid, 5-((Z)-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-

5-((Z)-1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-propanoic acid

PDGFR Tyrosine Kinase Inhibitor VI, SU6668

3-[2,4-dimethyl-5-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoicacid

PDGFR Tyrosine Kinase Inhibitor VI, SU6668 - CAS 210644-62-5 - Calbiochem

3-(2,4-Dimethyl-5-{[(3Z)-2-oxo-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)propanoic acid

(Z)?-?3-?(2,?4-?Dimethyl-?5-?((2-?oxoindolin-?3-?ylidene)?methyl)?-?1H-?pyrrol-?3-?yl)?propanoic acid (SU-6668)

(Z)-Orantinib

(Z)-SU6668

(Z)-TSU-68

5-(Z)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl-2,4-dimethyl-1H-pyrrol-3-propanoic acid

(Z)-Orantinib/SU6668/TSU-68)

210644-62-5