ChemicalBook > CAS DataBase List > SU 6668

SU 6668

Product Name
SU 6668
CAS No.
210644-62-5
Chemical Name
SU 6668
Synonyms
SU 6668;(Z)-SU6668;(Z)-TSU-68;(Z)-Orantinib;(Z)-Orantinib/SU6668/TSU-68);PDGFR Tyrosine Kinase Inhibitor VI, SU6668;PDGFR Tyrosine Kinase Inhibitor VI, SU6668 - CAS 210644-62-5 - Calbiochem;3-[2,4-dimethyl-5-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoicacid;3-(2,4-Dimethyl-5-{[(3Z)-2-oxo-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)propanoic acid;3-(2,4-Dimethyl-5-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrol-3-yl)-propionic acid
CBNumber
CB91312244
Molecular Formula
C18H18N2O3
Formula Weight
310.35
MOL File
210644-62-5.mol
More
Less

SU 6668 Property

storage temp. 
+2C to +8C
solubility 
DMSO : 50 mg/mL (161.11 mM; Need ultrasonic)
form 
Dark yellow solid
color 
Orange to red
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS023028
Product name
2,4-Dimethyl-5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-pyrrole-3-propanoic acid
Packaging
100MG
Price
$308
Updated
2023/01/07
Tocris
Product number
3335
Product name
SU6668
Purity
≥99%(HPLC)
Packaging
10
Price
$208
Updated
2021/12/16
TRC
Product number
D457088
Product name
(Z)​-​3-​(2,​4-​Dimethyl-​5-​((2-​oxoindolin-​3-​ylidene)​methyl)​-​1H-​pyrrol-​3-​yl)​propanoicacid(SU-6668)
Packaging
5mg
Price
$90
Updated
2021/12/16
Usbiological
Product number
256776
Product name
SU 6668
Packaging
10mg
Price
$466
Updated
2021/12/16
Matrix Scientific
Product number
132613
Product name
(Z)-3-(2,4-Dimethyl-5-((2-oxoindolin-3-ylidene)-methyl)-1H-pyrrol-3-yl)propanoicacid
Purity
97%
Packaging
250mg
Price
$537
Updated
2021/12/16
More
Less

SU 6668 Chemical Properties,Usage,Production

Uses

PDGFR Tyrosine Kinase Inhibitor VI, SU6668 is a potent ATP-competitive inhibitor against tyrosine kinases.

General Description

A cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFRβ, VEGFR2 (Flk-1/KDR), FGFR1 activity in vitro (IC50 = 0.01, 0.1, 3.9, and 3.8 μM, respectively) and PDGF/VEGF/bFGF-mediated angiogenesis and tumor development in vivo. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target ser/thr kinases Aurora A, Aurora B, TBK1 (NAK/T2K), and AMPK (IC50 = 0.85, 0.047, 1.4, and 1.8 μM, respectively), as well as non-receptor TKs Lyn and Yes (IC50 = 4.3 and 5.8 μM, respectively).

SU 6668 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

SU 6668 Suppliers

China 44 India 1 United States 7 Global 52
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58

210644-62-5, SU 6668Related Search:

3-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-pyrrolidine-2,5-dione INCB39110 X-376 Filgotinib Decernotinib Masitinib Lestaurtinib CAL-101 PLX3397 (Pexidartinib) CO-1686 Momelotinib 790299-79-5 AZD-6244 ARRY-334543 Dovitinib Volitinib

  • SU 6668
  • 3-(2,4-Dimethyl-5-(2-oxo-1,2-dihydroindol-3-ylidenemethyl)-1H-pyrrol-3-yl)-propionic acid
  • 1H-Pyrrole-3-propanoic acid, 5-((Z)-(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-
  • 5-((Z)-1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-propanoic acid
  • PDGFR Tyrosine Kinase Inhibitor VI, SU6668
  • 3-[2,4-dimethyl-5-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoicacid
  • PDGFR Tyrosine Kinase Inhibitor VI, SU6668 - CAS 210644-62-5 - Calbiochem
  • 3-(2,4-Dimethyl-5-{[(3Z)-2-oxo-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)propanoic acid
  • (Z)?-?3-?(2,?4-?Dimethyl-?5-?((2-?oxoindolin-?3-?ylidene)?methyl)?-?1H-?pyrrol-?3-?yl)?propanoic acid (SU-6668)
  • (Z)-Orantinib
  • (Z)-SU6668
  • (Z)-TSU-68
  • 5-(Z)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl-2,4-dimethyl-1H-pyrrol-3-propanoic acid
  • (Z)-Orantinib/SU6668/TSU-68)
  • 210644-62-5