1-N-Boc-3-Cyanopyrrolidine

Product Name: 1-N-Boc-3-Cyanopyrrolidine
CAS No.: 476493-40-0
Chemical Name: 1-N-Boc-3-Cyanopyrrolidine
Synonyms: TERT-BUTYL 3-CYANOPYRROLIDINE-1-CARBOXYLATE;N-Boc-3-cyanopyrrolidine;1-Boc-3-cyanopyrrolidine;N-1-BOC-3-CYANOPYRROLIDINE;1-N-BOC-3-CYANO-PYRROLIDINE;1,1-Dimethylethyl 3-cyano-1-pyrrolidinecarboxylate;3-CYANO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Pyrrolidinecarboxylic acid, 3-cyano-, 1,1-dimethylethyl ester
CBNumber: CB9135859
Molecular Formula: C10H16N2O2
Formula Weight: 196.25
MOL File: 476493-40-0.mol

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1-N-Boc-3-Cyanopyrrolidine Property

Boiling point:: 307.9±35.0 °C(Predicted)
Density: 1.08±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: -3.73±0.40(Predicted)
form: solid
color: Pale yellow
CAS DataBase Reference: 476493-40-0(CAS DataBase Reference)

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Safety

Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36/37/39
RIDADR: 3439
HazardClass: 6.1
PackingGroup: III
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B646200
Product name: 1-N-Boc-3-cyanopyrrolidine
Packaging: 250mg
Price: $70
Updated: 2021/12/16

TRC

Product number: B646200
Product name: 1-N-Boc-3-cyanopyrrolidine
Packaging: 1g
Price: $150
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 37600
Product name: 1-N-Boc-3-Cyanopyrrolidine
Packaging: 1g
Price: $400
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB140623
Product name: tert-Butyl 3-cyanopyrrolidine-1-carboxylate
Packaging: 10g
Price: $450
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-696
Product name: tert-Butyl 3-cyanopyrrolidine-1-carboxylate
Purity: 97.0%
Packaging: 5G
Price: $540
Updated: 2021/12/16

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1-N-Boc-3-Cyanopyrrolidine Chemical Properties,Usage,Production

Uses

1-N-Boc-3-cyanopyrrolidine is used to prepare aroyl-substituted pyrrolidines with monoamine reuptake inhibition activities.

Synthesis

773837-37-9

141699-57-2

476493-40-0

A solution was prepared from tert-butyl 3-(methylsulfonyloxy)pyrrolidine-1-carboxylate (2.65 g, 10 mmol) and sodium cyanide (2.5 g, 50 mmol) in N,N-dimethylformamide (100 mL). The reaction mixture was stirred at 100°C for 16 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was poured into water and extracted with ethyl acetate. The organic phases were combined, washed sequentially with water and saturated saline and dried over anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure and the resulting residue was purified by column chromatography (eluent: petroleum ether/ethyl acetate=5:1) to afford 1-N-Boc-3-cyanopyrrolidine (1.92 g, 98% yield).

References

[1] Patent: CN107474024, 2017, A. Location in patent: Paragraph 0385; 0392; 0393; 0394
[2] Patent: WO2017/211759, 2017, A1. Location in patent: Page/Page column 59; 60

1-N-Boc-3-Cyanopyrrolidine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-N-Boc-3-Cyanopyrrolidine Suppliers

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View Lastest Price from 1-N-Boc-3-Cyanopyrrolidine manufacturers

Career Henan Chemical Co

Product: 1-N-Boc-3-Cyanopyrrolidine 476493-40-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 150KG
Release date: 2019-07-01

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