Efaproxiral

Product Name: Efaproxiral
CAS No.: 131179-95-8
Chemical Name: Efaproxiral
Synonyms: Efaproxyn;faproxiral;Efaproxiral;EFAPROXIRALUM;Efaproxiral (RSR13);Efaproxiral free acid;EFAPROXIRAL;EFAPROXIRAL FREE ACID;FAPROXIRAL;2-[4-(3,5-Dimethylphenylcarbamoylmethyl)phenoxy]-2-methylpropionic acid;2-(4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy)-2-methylpropionic acid;Propanoic acid, 2-[4-[2-[(3,5-dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methyl-
CBNumber: CB91359078
Molecular Formula: C20H22NO4.Na
Formula Weight: 341.4
MOL File: 131179-95-8.mol

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Efaproxiral Property

Melting point:: 48-50°C
Boiling point:: 554.5±50.0 °C(Predicted)
Density: 1.202±0.06 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 3.26±0.10(Predicted)
color: Off-White to Tan

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28294
Product name: Efaproxiral
Packaging: 100mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 28294
Product name: Efaproxiral
Packaging: 1g
Price: $535
Updated: 2024/03/01

Cayman Chemical

Product number: 28294
Product name: Efaproxiral
Packaging: 250mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 28294
Product name: Efaproxiral
Packaging: 500mg
Price: $302
Updated: 2024/03/01

TRC

Product number: E415000
Product name: Efaproxiral
Packaging: 250mg
Price: $175
Updated: 2021/12/16

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Efaproxiral Chemical Properties,Usage,Production

Description

Efaproxiral is an allosteric hemoglobin (Hb) modifier that reduces the affinity of Hb for oxygen, increasing the diffusion of oxygen from blood to tissue. In isolated human whole blood, efaproxiral (1.75 mM) increases the partial pressure of oxygen at which Hb is 50% saturated (p50) from 26.75 to 38.63 mm Hg and decreases the percent oxyhemoglobin (Hb-O₂) saturation from 48 to 33.8% at a partial oxygen pressure (pO₂) of 26 mm Hg. Efaproxiral (150 mg/kg) increases tumor pO₂ from 5.2 to 13.1 mm Hg 30 minutes after administration in a RIF-1 mouse fibrosarcoma flank tumor model. Efaproxiral (100 μM) enhances radiation-induced cytotoxicity in EMT6 mouse breast cancer cells grown under hypoxic conditions and increases radiosensitization and inhibits tumor growth in a hypoxic Lewis lung tumor mouse model when administered at a dose of 100 mg/kg. It also increases the running capacity of normal mice and mice with left coronary artery (LCA) ligation-induced myocardial infarction (MI) when administered at a dose of 150 mg/kg.

Chemical Properties

Off-White to Tan Solid

Uses

Allosteric modifier of hemoglobin (HB). Binds in the central water cavity of the Hb molecule causing a conformational change such that bound oxygen is released more readily. Antineoplastic adjunct (radiosensitizer).

Efaproxiral Preparation Products And Raw materials

Raw materials

Preparation Products

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Efaproxiral Suppliers

Canada 1 China 51 India 1 United States 15 Global 68

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9984
Advantage: 60

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@163.com
Country: China
ProdList: 284
Advantage: 58

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32344
Advantage: 50

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9901
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
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AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3421
Advantage: 58

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2989
Advantage: 60

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View Lastest Price from Efaproxiral manufacturers

Career Henan Chemical Co

Product: Efaproxiral 131179-95-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95--99%
Supply Ability: 1ton
Release date: 2020-01-03

131179-95-8, EfaproxiralRelated Search:

N,N-Dimethyl-1,4-phenylenediamine Dimethylcarbamoyl chloride Folic acid Chlorodimethylphenylsilane POLY(PROPYLENE-CO-ETHYLENE) DIMETHYLAMINOPYRIDINE, POLYMER-BOUND phenoxybenzamine Efaproxiral sodium Diethoxydimethylsilane β-Alanine Dimethyldimethoxysilane Ascoric Acid EPDM RUBBER Phenoxyacetic acid sodium salt AKOS B013930 2-methyl-2-(4-methylphenoxy)propanoic acid 2-(4-HYDROXY-PHENYL)-N-PHENYL-ACETAMIDE 4-METHOXY-N-PHENYL-BENZENEETHANAMINE

EFAPROXIRAL;EFAPROXIRAL FREE ACID;FAPROXIRAL

2-(4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy)-2-methylpropionic acid

Efaproxiral

Efaproxiral free acid

faproxiral

EFAPROXIRALUM

2-[4-(3,5-Dimethylphenylcarbamoylmethyl)phenoxy]-2-methylpropionic acid

Propanoic acid, 2-[4-[2-[(3,5-dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methyl-

Efaproxiral (RSR13)

Efaproxyn

131179-95-8

C20H22NO4Na

Amines

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals