5-FLUORO-2-THIOPHENECARBOXYLIC ACID
Application- Product Name
- 5-FLUORO-2-THIOPHENECARBOXYLIC ACID
- CAS No.
- 4377-58-6
- Chemical Name
- 5-FLUORO-2-THIOPHENECARBOXYLIC ACID
- Synonyms
- AKOS B029946;4-fluorothiop;5-Carboxy-2-fluorothiophene;5-Fluoro-thiophene-2-carb...;5-Fluorothiophen-2-carboxylic acid;5-FLUORO-2-THIOPHENECARBOXYLIC ACID;4-fluorothiophene-2-carboxylic acid;5-Fluoro-thiophene-2-carboxylic acid;2-Thiophenecarboxylicacid, 5-fluoro-
- CBNumber
- CB9144895
- Molecular Formula
- C5H3FO2S
- Formula Weight
- 146.14
- MOL File
- 4377-58-6.mol
5-FLUORO-2-THIOPHENECARBOXYLIC ACID Property
- Melting point:
- 139-141℃
- Boiling point:
- 271.2±20.0 °C(Predicted)
- Density
- 1.527±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 3.52±0.10(Predicted)
- Appearance
- Off-white to yellow Solid
- InChI
- InChI=1S/C5H3FO2S/c6-4-2-1-3(9-4)5(7)8/h1-2H,(H,7,8)
- InChIKey
- XQURBTZGKJENJS-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)SC(F)=CC=1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- F402378
- Product name
- 5-Fluorothiophene-2-carboxylicAcid
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- F402378
- Product name
- 5-Fluorothiophene-2-carboxylicAcid
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- F402378
- Product name
- 5-Fluorothiophene-2-carboxylicAcid
- Packaging
- 500mg
- Price
- $330
- Updated
- 2021/12/16
- Product number
- CS-D0304
- Product name
- 5-Fluorothiophene-2-carboxylicacid
- Packaging
- 250mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- W6292
- Product name
- 5-Fluoro-2-thiophenecarboxylicacid
- Packaging
- 100mg
- Price
- $122
- Updated
- 2021/12/16
5-FLUORO-2-THIOPHENECARBOXYLIC ACID Chemical Properties,Usage,Production
Application
5-Fluorothiophene-2-carboxylic acid is an organic synthesis intermediate and a pharmaceutical intermediate that can be used in laboratory research and development processes and chemical production processes.
Synthesis
32415-91-1
4377-58-6
General procedure for the synthesis of 5-fluorothiophene-2-carboxylic acid from 5-fluorothiophene-2-carbonitrile: 138 mg (1.07 mmol) of 5-fluorothiophene-2-carbonitrile and 5 ml of 1N sodium hydroxide solution were added to an eggplant flask, and the mixture was heated and stirred in an oil bath at 100 °C for 2 hours. After completion of the reaction, the reaction solution was cooled to room temperature. Subsequently, 5 ml of water was added to the reaction solution for dilution and the pH was adjusted with 10 ml of 1N hydrochloric acid to 1. Next, the mixture was extracted twice with 30 ml of dichloromethane. The organic layers were combined and dried with anhydrous sodium sulfate. Finally, the solvent was removed by concentration under reduced pressure to give 110 mg of 5-fluorothiophene-2-carboxylic acid.
References
[1] Patent: US6043379, 2000, A
[2] Patent: US6096901, 2000, A
[3] Patent: US2013/137730, 2013, A1. Location in patent: Paragraph 0092
5-FLUORO-2-THIOPHENECARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-FLUORO-2-THIOPHENECARBOXYLIC ACID manufacturers
- Product
- 5-FLUORO-2-THIOPHENECARBOXYLIC ACID 4377-58-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- 5-FLUORO-2-THIOPHENECARBOXYLIC ACID 4377-58-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-09