ChemicalBook > CAS DataBase List > Methyl 5-hydroxynicotinate
Methyl 5-hydroxynicotinate
- Product Name
- Methyl 5-hydroxynicotinate
- CAS No.
- 30766-22-4
- Chemical Name
- Methyl 5-hydroxynicotinate
- Synonyms
- 5-Hydroxynicotinate;METHYL 5-HYDROXYNICOTINATE;5- hydroxyMethyl nicotinate;Methyl5-Hydroxynicotinate>Methyl 5-hydroxynicotinate 98%;Hydroxynicotinicacidmethylester;METHYL 5-HYDROXYNICOTINATE, 97+%;5-HYDROXYNICOTINIC ACID METHYL ESTER;Methyl 5-hydroxynicotinate methy ester;Methyl 5-hydroxypyridine-3-carboxylate
- CBNumber
- CB9145256
- Molecular Formula
- C7H7NO3
- Formula Weight
- 153.14
- MOL File
- 30766-22-4.mol
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Methyl 5-hydroxynicotinate Property
- Melting point:
- 190 °C
- Boiling point:
- 374.2±22.0 °C(Predicted)
- Density
- 1.287±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO (Heated, Sonicated), Methanol (Slightly, Sonicated)
- pka
- 8.44±0.10(Predicted)
- form
- Powder and Lumps
- color
- Light beige
- InChI
- InChI=1S/C7H7NO3/c1-11-7(10)5-2-6(9)4-8-3-5/h2-4,9H,1H3
- InChIKey
- KJJSHOHQQHACLE-UHFFFAOYSA-N
- SMILES
- C1=NC=C(O)C=C1C(OC)=O
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Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-41-37/38
- Safety Statements
- 26-36/37/39-39-37/39
- WGK Germany
- 3
- Hazard Note
- Irritant/Keep Cold
- HS Code
- 29333990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 689246
- Product name
- Methyl 5-hydroxy-3-pyridinecarboxylate
- Purity
- 97%
- Packaging
- 1g
- Price
- $128
- Updated
- 2023/06/20
Sigma-Aldrich
- Product number
- 689246
- Product name
- Methyl 5-hydroxy-3-pyridinecarboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $607
- Updated
- 2023/06/20
TCI Chemical
- Product number
- H0841
- Product name
- Methyl 5-Hydroxynicotinate
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $78
- Updated
- 2025/07/31
TCI Chemical
- Product number
- H0841
- Product name
- Methyl 5-Hydroxynicotinate
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $234
- Updated
- 2025/07/31
TCI Chemical
- Product number
- H0841
- Product name
- Methyl 5-Hydroxynicotinate
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $696
- Updated
- 2025/07/31
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Methyl 5-hydroxynicotinate Chemical Properties,Usage,Production
Chemical Properties
Light beige powder and lumps
Uses
Methyl 5-Hydroxynicotinate is an intermediate used to prepare selective cyclooxygenase-2 inhibitors. It is also used to prepare imino sugars as inhibitors of liver glycogen phosphorylase.
Synthesis
67-56-1
27828-71-3
30766-22-4
Method A. Step A. Synthesis of methyl 5-hydroxynicotinate. 5-Hydroxynicotinic acid (833 g, 5.99 mol) was dissolved in methanol (6.7 L), and concentrated sulfuric acid (292 mL) was slowly added dropwise, with the rate of dropwise acceleration controlled to maintain the temperature of the reaction mixture at 30°C. After the dropwise addition, the reaction mixture was stirred under reflux conditions for 7 days. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated under reduced pressure. Water (4 L) was added to the concentrate and the pH of the mixture was adjusted to 8 with sodium bicarbonate (NaHCO3), at which point a white solid precipitated. The mixture was stirred at room temperature for 1 h. The solid was collected by filtration and dried under vacuum at 60 °C for 3 days to afford the target product methyl 5-hydroxynicotinate (783 g, 85% yield) as a white solid. The product was characterized by 1H NMR (DMSO-d6, 400 MHz): δ 10.46 (s, 1H), 8.54 (s, 1H), 8.34-8.35 (d, J = 2.8 Hz, 1H), 7.59 (s, 1H), 3.85 (s, 3H).
References
[1] Patent: WO2015/164508, 2015, A1. Location in patent: Page/Page column 52
[2] Patent: WO2008/154563, 2008, A1. Location in patent: Page/Page column 91-92
[3] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 4, p. 606 - 611
[4] Patent: WO2014/154727, 2014, A1. Location in patent: Page/Page column 43
[5] Patent: US2014/296239, 2014, A1. Location in patent: Paragraph 0114; 0115
Methyl 5-hydroxynicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 5-hydroxynicotinate manufacturers
Henan Aochuang Chemical Co.,Ltd.
- Product
- Methyl 5-hydroxynicotinate 30766-22-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-09
Shijiazhuang Dowell Chemical Co.,Ltd
- Product
- Methyl 5-hydroxynicotinate 30766-22-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2025-03-23
Shijiazhuang Dowell Chemical Co.,Ltd
- Product
- Methyl 5-hydroxynicotinate 30766-22-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 500kg/month
- Release date
- 2024-12-10
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