(R)-1-BOC-3-HYDROXYMETHYLPIPERIDINE ETHYL ESTER

Product Name: (R)-1-BOC-3-HYDROXYMETHYLPIPERIDINE ETHYL ESTER
CAS No.: 194726-40-4
Chemical Name: (R)-1-BOC-3-HYDROXYMETHYLPIPERIDINE ETHYL ESTER
Synonyms: Ethyl (R)-1-Boc-nipecotate;Ethyl 1-Boc-D-nipecotate, 95%;Ethyl N-Boc-D-nipecotate, 95%;(R)-1-Boc-nipecotic Acid Ethyl Ester;Ethyl (R)-1-Boc-3-piperidinecarboxylate;Ethyl (R)-N-Boc-piperidine-3-carboxylate;[R]-1-BOC-Ethyl piperidine-3-carboxylate;[S]-1-BOC-Ethyl piperidine-3-carboxylate;Ethyl (R)-1-Boc-piperidine-3-carboxylate;(R)-ETHYL N-BOC-PIPERIDINE-3-CARBOXYLATE
CBNumber: CB91471002
Molecular Formula: C13H23NO4
Formula Weight: 257.33
MOL File: 194726-40-4.mol

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(R)-1-BOC-3-HYDROXYMETHYLPIPERIDINE ETHYL ESTER Property

Melting point:: 35.0 to 39.0 °C
Boiling point:: 323.9±35.0 °C(Predicted)
Density: 1.077
Flash point:: >110℃
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
form: powder to lump to clear liquid
pka: -2.40±0.40(Predicted)
color: White or Colorless to Almost white or Almost colorless

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36/37
WGK Germany: 3
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 696412
Product name: Ethyl (R)-N-Boc-piperidine-3-carboxylate
Purity: 95%
Packaging: 1g
Price: $135
Updated: 2023/01/07

TCI Chemical

Product number: E0948
Product name: Ethyl (R)-1-(tert-Butoxycarbonyl)-3-piperidinecarboxylate
Purity: >98.0%(GC)
Packaging: 5g
Price: $151
Updated: 2025/07/31

Chem-Impex

Product number: 41510
Product name: Ethyl(R)-N-Boc-piperidine-3-carboxylate,95%
Purity: 95%
Packaging: 1G
Price: $107.52
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-1-R16
Product name: (R)-1-Boc-ethyl piperidine-3-carboxylate
Packaging: 1g
Price: $120
Updated: 2021/12/16

AK Scientific

Product number: X3049
Product name: (R)-N-Boc-ethylpiperidine-3-carboxylate
Packaging: 10g
Price: $477
Updated: 2021/12/16

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(R)-1-BOC-3-HYDROXYMETHYLPIPERIDINE ETHYL ESTER Chemical Properties,Usage,Production

Synthesis

75-03-6

163438-09-3

194726-40-4

Under mechanical stirring, (R)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid (1 kg, 4.36 mol) was dissolved in N,N-dimethylacetamide (3 L), followed by addition of potassium carbonate (0.664 kg, 4.80 mol). The resulting suspension was stirred at room temperature for 30 min. Ethyl iodide (0.75 kg, 4.80 mol) was slowly added through the addition funnel and stirring was continued at room temperature for 15 min, followed by warming to 50 °C and stirring for 1 h. The reaction was carried out by thin layer chromatography (TLC). The reaction process was monitored by thin layer chromatography (TLC, unfolding agent ratio ethyl acetate:hexane=1:1). Upon completion of the reaction, the reaction mixture was cooled to room temperature and diluted with ethyl acetate (5 L). Insoluble material was removed by diafiltration and the wet filter cake was washed with ethyl acetate (5L). The filtrates were combined and mixed with 5% w/v sodium thiosulfate solution (15L) with stirring, and the organic phase was separated by layering. The aqueous phase was extracted once more with ethyl acetate (5L). All organic layers were combined, washed with water (5L) and dried with anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure to give a semi-solid product, which solidified on standing to ethyl (R)-1-Boc-piperidine-3-dicarboxylate in a yield of 1.1 kg and 99.5%.

References

[1] Patent: WO2014/135931, 2014, A1. Location in patent: Page/Page column 10
[2] Patent: US9657021, 2017, B2. Location in patent: Page/Page column 8; 9

(R)-1-BOC-3-HYDROXYMETHYLPIPERIDINE ETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-1-BOC-3-HYDROXYMETHYLPIPERIDINE ETHYL ESTER Suppliers

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194726-40-4, (R)-1-BOC-3-HYDROXYMETHYLPIPERIDINE ETHYL ESTERRelated Search:

(R)-(-)-Nipecotic acid (R)-Methyl nipecotate N-Boc-piperidine-3-methanol (R)-Boc-Nipecotic acid (R)-Ethyl 1-methylpiperidine-3-carboxylate Ethyl 1-Boc-3-piperidinecarboxylate (R)-1-(TERT-BUTOXYCARBONYL)-3-PIPERIDINECARBOXALDEHYDE Methyl N-Boc-piperidine-3-carboxylate (R)-1-BOC-3-HYDROXYMETHYLPIPERIDINE ETHYL ESTER

(R)-1-BOC-3-HYDROXYMETHYLPIPERIDINE ETHYL ESTER

1,3-Piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) 3-ethyl ester, (3R)- (9CI)

1,3-Piperidinedicarboxylic acid, 1-(1,1-dimethylethyl) 3-ethyl ester, (3R)-

(R)-1,3-Piperidinedicarboxylic acid 1-tert-butyl 3-ethyl ester

Ethyl (R)-N-Boc-piperidine-3-carboxylate

Ethyl (R)-1-(tert-Butoxycarbonyl)-3-piperidinecarboxylate

Ethyl (3R)-1-tert-butoxycarbonyl-3-piperidinecarboxylate

Ethyl (R)-1-Boc-nipecotate

(R)-1-(tert-Butoxycarbonyl)-piperidine-3-carboxylic acid ethyl ester

Ethyl N-Boc-D-nipecotate, 95%

Ethyl 1-Boc-D-nipecotate, 95%

[R]-1-BOC-Ethyl piperidine-3-carboxylate

[S]-1-BOC-Ethyl piperidine-3-carboxylate

Ethyl (R)-N-Boc-piperidine-3-carboxylate

Ethyl(R)-1-Boc-nipecotatetert-butyl3-ethyl ester

Ethyl (R)-1-Boc-piperidine-3-carboxylate

(R)-1-Boc-3-piperidinecarboxylic Acid Ethyl Ester

(R)-ETHYL N-BOC-PIPERIDINE-3-CARBOXYLATE

O1-tert-butyl O3-ethyl (3R)-piperidine-1,3-dicarboxylate

1-O-tert-butyl 3-O-ethyl (3R)-piperidine-1,3-dicarboxylate

Ethyl(R)-1-(tert-Butoxycarbonyl)-3-piperidinecarboxylate&gt

(R)-1-(tert-Butoxycarbonyl)-3-piperidinecarboxylic Acid Ethyl Ester

(R)-1-(tert-Butoxycarbonyl)nipecotic Acid Ethyl Ester

(R)-1-Boc-nipecotic Acid Ethyl Ester

Ethyl (R)-1-Boc-3-piperidinecarboxylate

Ethyl (R)-N-Boc-piperidine-3-carboxylate

194726-40-4