TERT-BUTYL [5-(HYDROXYMETHYL)PYRIDIN-2-YL)CARBAMATE
- Product Name
- TERT-BUTYL [5-(HYDROXYMETHYL)PYRIDIN-2-YL)CARBAMATE
- CAS No.
- 169280-83-5
- Chemical Name
- TERT-BUTYL [5-(HYDROXYMETHYL)PYRIDIN-2-YL)CARBAMATE
- Synonyms
- tert-butyl 5-(hydroxyMeth...;2-(Boc-amino)-5-pyridinemethanol;2-(Boc-amino)-5-pyridinemethanol ,97%;N-Boc-5-(hydroxymethyl)-2-pyridineamine;tert-butyl N-[5-(hydroxymethyl)pyridin-2-yl]carbamate;6-(N-tert-Butoxycarbonylamino)-3-hydroxymethylpyridine;2-(tert-Butoxycarbonylamino)-5-(hydroxymethyl)pyridine;1,1-Dimethylethyl N-[5-(hydroxymethyl)-2-pyridinyl]carbamate;N-[5-(hydroxymethyl)-2-pyridinyl]carbamic acid tert-butyl ester;CarbaMic acid, N-[5-(hydroxyMethyl)-2-pyridinyl]-, 1,1-diMethylethyl ester
- CBNumber
- CB91473662
- Molecular Formula
- C11H16N2O3
- Formula Weight
- 224.26
- MOL File
- 169280-83-5.mol
TERT-BUTYL [5-(HYDROXYMETHYL)PYRIDIN-2-YL)CARBAMATE Property
- Boiling point:
- 332.8±32.0 °C(Predicted)
- Density
- 1.209
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 12.35±0.70(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- T135703
- Product name
- tert-ButylN-[5-(Hydroxymethyl)pyridin-2-yl]carbamate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 4H56-1-NM
- Product name
- tert-Butyl 5-(hydroxymethyl)pyridin-2-ylcarbamate
- Packaging
- 250mg
- Price
- $84
- Updated
- 2021/12/16
- Product number
- Y7789
- Product name
- tert-Butyl5-(hydroxymethyl)pyridin-2-ylcarbamate
- Packaging
- 1g
- Price
- $166
- Updated
- 2021/12/16
- Product number
- 4H56-1-NM
- Product name
- tert-Butyl 5-(hydroxymethyl)pyridin-2-ylcarbamate
- Packaging
- 1g
- Price
- $280
- Updated
- 2021/12/16
- Product number
- 112750
- Product name
- tert-Butyl 5-(hydroxymethyl)pyridin-2-ylcarbamate
- Packaging
- 1g
- Price
- $319
- Updated
- 2021/12/16
TERT-BUTYL [5-(HYDROXYMETHYL)PYRIDIN-2-YL)CARBAMATE Chemical Properties,Usage,Production
Chemical Properties
White solid
Synthesis
169280-82-4
169280-83-5
To a stirred solution of ethyl 6-(tert-butoxycarbonylamino)nicotinate (100; 10.0 g, 27.3 mmol) in tetrahydrofuran (THF) (40 mL) was slowly added a solution of lithium aluminum hydroxide (LA1H4) (1.92 g, 50.5 mmol) in THF (60 mL) over 30 min, keeping the reaction temperature not below 0 °C. The reaction mixture was continued to be stirred at 0 °C for 6 hours. Upon completion of the reaction, water (1.0 mL) and 10% sodium hydroxide (NaOH) solution (2.0 mL) were carefully added at 0 °C to quench the reaction. The resulting mixture was filtered and the filtrate was dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The residue was purified by column chromatography (eluent ratio dichloromethane: methanol = 40:1) to afford the target product tert-butyl 5-(hydroxymethyl)pyridin-2-ylcarbamate 101 (4.50 g, 74% yield).
References
[1] Patent: WO2010/3048, 2010, A1. Location in patent: Page/Page column 110
[2] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 5, p. 1151 - 1175
[3] Patent: WO2014/52365, 2014, A1. Location in patent: Page/Page column 257-258
[4] Patent: US6046190, 2000, A
[5] Patent: US5968942, 1999, A
TERT-BUTYL [5-(HYDROXYMETHYL)PYRIDIN-2-YL)CARBAMATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from TERT-BUTYL [5-(HYDROXYMETHYL)PYRIDIN-2-YL)CARBAMATE manufacturers
- Product
- 2-(Boc-amino)-5-pyridinemethanol 169280-83-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.0001kg
- Purity
- 98%min
- Supply Ability
- 100kgs/month
- Release date
- 2022-05-10
- Product
- TERT-BUTYL [5-(HYDROXYMETHYL)PYRIDIN-2-YL)CARBAMATE 169280-83-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-25