ChemicalBook > CAS DataBase List > TERT-BUTYL [5-(HYDROXYMETHYL)PYRIDIN-2-YL)CARBAMATE

TERT-BUTYL [5-(HYDROXYMETHYL)PYRIDIN-2-YL)CARBAMATE

Product Name: TERT-BUTYL [5-(HYDROXYMETHYL)PYRIDIN-2-YL)CARBAMATE
CAS No.: 169280-83-5
Chemical Name: TERT-BUTYL [5-(HYDROXYMETHYL)PYRIDIN-2-YL)CARBAMATE
Synonyms: tert-butyl 5-(hydroxyMeth...;2-(Boc-amino)-5-pyridinemethanol;2-(Boc-amino)-5-pyridinemethanol ,97%;N-Boc-5-(hydroxymethyl)-2-pyridineamine;tert-butyl N-[5-(hydroxymethyl)pyridin-2-yl]carbamate;6-(N-tert-Butoxycarbonylamino)-3-hydroxymethylpyridine;2-(tert-Butoxycarbonylamino)-5-(hydroxymethyl)pyridine;1,1-Dimethylethyl N-[5-(hydroxymethyl)-2-pyridinyl]carbamate;N-[5-(hydroxymethyl)-2-pyridinyl]carbamic acid tert-butyl ester;CarbaMic acid, N-[5-(hydroxyMethyl)-2-pyridinyl]-, 1,1-diMethylethyl ester
CBNumber: CB91473662
Molecular Formula: C11H16N2O3
Formula Weight: 224.26
MOL File: 169280-83-5.mol

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TERT-BUTYL [5-(HYDROXYMETHYL)PYRIDIN-2-YL)CARBAMATE Property

Boiling point:: 332.8±32.0 °C(Predicted)
Density: 1.209
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 12.35±0.70(Predicted)
Appearance: White to off-white Solid

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-37
HS Code: 29309090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: T135703
Product name: tert-ButylN-[5-(Hydroxymethyl)pyridin-2-yl]carbamate
Packaging: 100mg
Price: $60
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-NM
Product name: tert-Butyl 5-(hydroxymethyl)pyridin-2-ylcarbamate
Packaging: 250mg
Price: $84
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-NM
Product name: tert-Butyl 5-(hydroxymethyl)pyridin-2-ylcarbamate
Packaging: 1g
Price: $280
Updated: 2021/12/16

Matrix Scientific

Product number: 112750
Product name: tert-Butyl 5-(hydroxymethyl)pyridin-2-ylcarbamate
Packaging: 1g
Price: $319
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-NM
Product name: tert-Butyl 5-(hydroxymethyl)pyridin-2-ylcarbamate
Packaging: 5G
Price: $920
Updated: 2021/12/16

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TERT-BUTYL [5-(HYDROXYMETHYL)PYRIDIN-2-YL)CARBAMATE Chemical Properties,Usage,Production

Chemical Properties

White solid

Synthesis

169280-82-4

169280-83-5

To a stirred solution of ethyl 6-(tert-butoxycarbonylamino)nicotinate (100; 10.0 g, 27.3 mmol) in tetrahydrofuran (THF) (40 mL) was slowly added a solution of lithium aluminum hydroxide (LA1H4) (1.92 g, 50.5 mmol) in THF (60 mL) over 30 min, keeping the reaction temperature not below 0 °C. The reaction mixture was continued to be stirred at 0 °C for 6 hours. Upon completion of the reaction, water (1.0 mL) and 10% sodium hydroxide (NaOH) solution (2.0 mL) were carefully added at 0 °C to quench the reaction. The resulting mixture was filtered and the filtrate was dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The residue was purified by column chromatography (eluent ratio dichloromethane: methanol = 40:1) to afford the target product tert-butyl 5-(hydroxymethyl)pyridin-2-ylcarbamate 101 (4.50 g, 74% yield).

References

[1] Patent: WO2010/3048, 2010, A1. Location in patent: Page/Page column 110
[2] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 5, p. 1151 - 1175
[3] Patent: WO2014/52365, 2014, A1. Location in patent: Page/Page column 257-258
[4] Patent: US6046190, 2000, A
[5] Patent: US5968942, 1999, A

TERT-BUTYL [5-(HYDROXYMETHYL)PYRIDIN-2-YL)CARBAMATE Preparation Products And Raw materials

Raw materials

Acetonitrile Acetic anhydride Di-tert-butyl dicarbonate Tetrahydrofuran Lithium Aluminum Hydride Methanol Thionyl chloride 6-Aminonicotinic acid

Preparation Products

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TERT-BUTYL [5-(HYDROXYMETHYL)PYRIDIN-2-YL)CARBAMATE Suppliers

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View Lastest Price from TERT-BUTYL [5-(HYDROXYMETHYL)PYRIDIN-2-YL)CARBAMATE manufacturers

Shanghai Rlavie Technology Co ltd

Product: 2-(Boc-amino)-5-pyridinemethanol 169280-83-5
Price: US $0.00-0.00/kg
Min. Order: 0.0001kg
Purity: 98%min
Supply Ability: 100kgs/month
Release date: 2022-05-10

Career Henan Chemical Co

Product: TERT-BUTYL [5-(HYDROXYMETHYL)PYRIDIN-2-YL)CARBAMATE 169280-83-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-25

169280-83-5, TERT-BUTYL [5-(HYDROXYMETHYL)PYRIDIN-2-YL)CARBAMATERelated Search:

METHYL 6-[(TERT-BUTOXYCARBONYL)AMINO]NICOTINATE 2-(BOC-AMINO)-5-PICOLINE (5-METHOXYMETHYL-PYRIDIN-2-YL)-CARBAMIC ACID TERT-BUTYL ESTER TERT-BUTYL [5-(HYDROXYMETHYL)PYRIDIN-2-YL)CARBAMATE 6-[(TERT-BUTOXYCARBONYL)AMINO]NICOTINIC ACID

2-(Boc-amino)-5-pyridinemethanol

tert-butyl 5-(hydroxyMeth...

2-(Boc-amino)-5-pyridinemethanol ,97%

2-(tert-Butoxycarbonylamino)-5-(hydroxymethyl)pyridine

6-(N-tert-Butoxycarbonylamino)-3-hydroxymethylpyridine

CarbaMic acid, N-[5-(hydroxyMethyl)-2-pyridinyl]-, 1,1-diMethylethyl ester

tert-butyl N-[5-(hydroxymethyl)pyridin-2-yl]carbamate

N-Boc-5-(hydroxymethyl)-2-pyridineamine

N-[5-(hydroxymethyl)-2-pyridinyl]carbamic acid tert-butyl ester

1,1-Dimethylethyl N-[5-(hydroxymethyl)-2-pyridinyl]carbamate

169280-83-5