4-Hydroxy-3,5-dimethylbenzoic acid
- Product Name
- 4-Hydroxy-3,5-dimethylbenzoic acid
- CAS No.
- 4919-37-3
- Chemical Name
- 4-Hydroxy-3,5-dimethylbenzoic acid
- Synonyms
- RARECHEM AL BO 0868;2,6-DiMethyl-4-carboxyphenol;4-Hydroxy-3,5-Dimethylbenzoic;4-hydroxy-3,5-dimethylbenzoate;4-Hydroxy-3,5-dimethylbenzoicaci;4-HYDROXY-3,5-DIMETHYLBENZOIC ACID;3,5-DIMETHYL-4-HYDROXYBENZOIC ACID;4-Hydroxy-3,5-dimethylbenzoicAcid>Benzoic acid, 4-hydroxy-3,5-dimethyl-;4-Hydroxy-3,5-dimethylbenzoic acid,98%
- CBNumber
- CB9157763
- Molecular Formula
- C9H10O3
- Formula Weight
- 166.17
- MOL File
- 4919-37-3.mol
4-Hydroxy-3,5-dimethylbenzoic acid Property
- Melting point:
- 221-226 °C
- Boiling point:
- 254.38°C (rough estimate)
- Density
- 1.1708 (rough estimate)
- refractive index
- 1.5500 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Soluble in methanol.
- pka
- 4.71±0.10(Predicted)
- form
- Crystalline Powder
- color
- Off-white to light pink or light beige
- BRN
- 2576289
- CAS DataBase Reference
- 4919-37-3(CAS DataBase Reference)
- NIST Chemistry Reference
- 3,5-Dimethyl-4-hydroxybenzoic acid(4919-37-3)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- H0938
- Product name
- 4-Hydroxy-3,5-dimethylbenzoic Acid
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $113
- Updated
- 2025/07/31
- Product number
- H941475
- Product name
- 4-Hydroxy-3,5-dimethylbenzoic Acid
- Packaging
- 25g
- Price
- $400
- Updated
- 2021/12/16
- Product number
- 6672AB
- Product name
- 4-Hydroxy-3,5-dimethylbenzoic Acid
- Packaging
- 25g
- Price
- $316
- Updated
- 2021/12/16
- Product number
- CHM0011789
- Product name
- 4-HYDROXY-3,5-DIMETHYLBENZOIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $631.85
- Updated
- 2021/12/16
- Product number
- CHM0011789
- Product name
- 4-HYDROXY-3,5-DIMETHYLBENZOIC ACID
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $892.58
- Updated
- 2021/12/16
4-Hydroxy-3,5-dimethylbenzoic acid Chemical Properties,Usage,Production
Chemical Properties
off-white to light pink or light beige crystalline
Uses
4-hydroxy-3,5-dimethylbenzoic acid is widely used as a reagent for potent TTR amyloidogenesis inhibitors. It plays an important role as an intermediate in agrochemicals and dyestuffs. It is also used in the preparation of mexiletine derivatives.
Synthesis
67-56-1
99-96-7
4919-37-3
(1) In a 500 mL three-necked flask, p-hydroxybenzoic acid (138 g, 1 mmol) and methanol (160 g, 5 mmol) were added, followed by solid acid catalyst (50 g). The mixture was stirred until homogeneous. The reaction flask was placed in an ultrasonic reactor and fitted with a reflux condensing unit. The reaction temperature was adjusted to 40-60°C and the ultrasonic power was set to 500 W for 1-3 hours. During the reaction, the color of the reaction solution gradually changed from white to yellow and finally to orange-red. The reaction process was monitored by high performance liquid chromatography (HPLC), and the reaction was judged to be complete when the residual amount of p-hydroxybenzoic acid was less than 5%. After stopping the reaction, the solid acid catalyst was removed by filtration (the catalyst can be recycled for subsequent reactions). The filtrate was allowed to crystallize at 5-10°C for 6-10 hours, after which the crystals were collected by filtration. The crystals were dried at 50-60°C for 6 h. The intermediate 4-hydroxy-3,5-dimethylbenzoic acid (141 g, 85% yield) was obtained by HPLC with impurity content of less than 0.1% in the product.
References
[1] Patent: CN106588576, 2017, A. Location in patent: Paragraph 0074-0080
4-Hydroxy-3,5-dimethylbenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
4-Hydroxy-3,5-dimethylbenzoic acid Suppliers
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- chemcontrol@nextra.sk
- Country
- Slovakia
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View Lastest Price from 4-Hydroxy-3,5-dimethylbenzoic acid manufacturers
- Product
- 4-Hydroxy-3,5-dimethylbenzoic acid 4919-37-3
- Price
- US $1.00-2.10/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20000KG
- Release date
- 2024-08-09
- Product
- 4-Hydroxy-3,5-dimethylbenzoicacid 4919-37-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.7%
- Supply Ability
- 100 tons
- Release date
- 2022-01-14
- Product
- 4-Hydroxy-3,5-dimethylbenzoic acid 4919-37-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2019-07-11