(4-Nitrophenyl)methanesulfonyl chloride
- Product Name
- (4-Nitrophenyl)methanesulfonyl chloride
- CAS No.
- 4025-75-6
- Chemical Name
- (4-Nitrophenyl)methanesulfonyl chloride
- Synonyms
- Sumatriptan Impurity 8;(4-Nitrophenyl)methanesulfonyl;1-(4-NITROBENZYLSULFONYL)CHLORIDE;4-Nitro-α-toluenesulfonyl chloride;(4-Nitrophenyl)methylsulfonyl chloride;4-Nitrobenzenemethanesulfonyl chloride;4-Nitro-alpha-toluenesulfonyl chloride;4-[(Chlorosulphonyl)methyl]nitrobenzene;(4-NITROPHENYL)METHANESULFONYL CHLORIDE;4-Nitro-ɑ-toluenesulfonyl chloride, 97%
- CBNumber
- CB9169634
- Molecular Formula
- C7H6ClNO4S
- Formula Weight
- 235.64
- MOL File
- 4025-75-6.mol
(4-Nitrophenyl)methanesulfonyl chloride Property
- Melting point:
- 91-92°C
- Boiling point:
- 396.4±25.0 °C(Predicted)
- Density
- 1.570±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Yellow to brown Solid
- Water Solubility
- Reacts with water.
- Sensitive
- Moisture Sensitive
- CAS DataBase Reference
- 4025-75-6(CAS DataBase Reference)
Safety
- Hazard Codes
- C,Xn
- Risk Statements
- 14-29-34-22
- Safety Statements
- 22-26-30-36/37/39-45
- RIDADR
- UN3261
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 2904990090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
H318Causes serious eye damage
- Precautionary statements
-
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- N495828
- Product name
- 4-NitrobenzylsulfonylChloride
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CHM0015547
- Product name
- (4-NITROPHENYL)METHANESULFONYL CHLORIDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $721.57
- Updated
- 2021/12/16
- Product number
- CHM0015547
- Product name
- (4-NITROPHENYL)METHANESULFONYL CHLORIDE
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $983.88
- Updated
- 2021/12/16
- Product number
- CHM0015547
- Product name
- (4-NITROPHENYL)METHANESULFONYL CHLORIDE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1168.42
- Updated
- 2021/12/16
- Product number
- OR4716
- Product name
- (4-Nitrophenyl)methanesulphonylchloride
- Purity
- tech
- Packaging
- 5g
- Price
- $163
- Updated
- 2021/12/16
(4-Nitrophenyl)methanesulfonyl chloride Chemical Properties,Usage,Production
Uses
4-Nitrobenzylsulfonyl Chloride is used for preparation of HIV-1 Tat protein via native chemical ligation between a peptide thioester and a peptide containing (mercapto)leucine at N-terminus followed by desulfurization.
Synthesis
64039-36-7
4025-75-6
The general procedure for the synthesis of (4-nitrophenyl)methanesulfonyl chloride from 4-nitrophenylaminosulfate methyl ester hydrochloride is as follows: 1. the alkyl halide (or sulfate) (5 mmol) was heated with thiourea (0.381 g, 5 mmol) in ethanol (5 mL) at reflux for 1 hour. 2. Upon completion of the reaction, the solvent was removed under vacuum and the residue was washed with ether (3 x 5 mL) to afford the corresponding S-alkyl isothiourea salt as a white solid in near quantitative yield. 3. Without further purification, the resulting S-alkylisothiourea salt was transferred to a three-necked round-bottomed flask equipped with a thermometer and a charging funnel and placed in an ice bath. 4. Water (0.45 mL) and acetonitrile (10 mL) were added to the flask to form a vigorously stirred mixture. 5. A solution of tert-butyl hypochlorite (t-BuOCl, 2.86 mL) in acetonitrile (5 mL) was added slowly and dropwise while maintaining an internal temperature of 0-20°C. The solution was then mixed with water (0.45 mL) and acetonitrile (10 mL). 6. After the dropwise addition was completed, the reaction mixture was continued to be stirred for 30 minutes. 7. Upon completion of the reaction, the solvent was removed under vacuum and ether (15 mL) was added to dissolve the residue. 8. The ether layer was washed with water (2 x 10 mL) and dried with anhydrous sodium sulfate (Na2SO4). 9. 9. After drying, the ether solution is concentrated in vacuum to give high purity (4-nitrophenyl)methanesulfonyl chloride. 10. The product can be further purified by recrystallization from a mixed petroleum ether-ethyl acetate solvent.
References
[1] Synthesis (Germany), 2015, vol. 47, # 20, p. 3186 - 3190
[2] Synlett, 2013, vol. 24, # 16, p. 2165 - 2169
[3] Synthesis (Germany), 2014, vol. 46, # 2, p. 225 - 229
(4-Nitrophenyl)methanesulfonyl chloride Preparation Products And Raw materials
Raw materials
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View Lastest Price from (4-Nitrophenyl)methanesulfonyl chloride manufacturers
- Product
- (4-Nitrophenyl)methanesulfonyl chloride 4025-75-6
- Price
- US $2.20-8.80/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 100kg
- Release date
- 2025-08-29
- Product
- (4-Nitrophenyl)methanesulfonyl chloride 4025-75-6
- Price
- US $1.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100000KG
- Release date
- 2024-07-26
- Product
- (4-Nitrophenyl)methanesulfonyl chloride 4025-75-6
- Price
- US $7.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-21