(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid

Product Name: (S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid
CAS No.: 17257-71-5
Chemical Name: (S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid
Synonyms: (-)-MTPA;(S)-(-)-MPTA;MOSHERS ACID;(-)-MOSHER'S ACID;(S)-(-)-Mosheracid;(S)-(-)-MOSHER'S ACID;(-)-MTPA, Moshers acid;(-)-Moshers acid~(-)-MTPA;(S)-(-)-MTPA,(S)-(-)-Mosher'sacid;(-)-A-METHOXY-A-TRIFLUOROMETHYLPHENYLACETIC ACID
CBNumber: CB9171585
Molecular Formula: C10H9F3O3
Formula Weight: 234.17
MOL File: 17257-71-5.mol

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(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid Property

Melting point:: 46-49 °C(lit.)
Boiling point:: 95-97 °C0.05 mm Hg(lit.)
alpha: D24 -71.8± 0.6° (c = 3.28 in CH3OH)
Density: 1.303 g/mL at 25 °C(lit.)
refractive index: n20/D 1.474(lit.)
Flash point:: >230 °F
storage temp.: 2-8°C
solubility: Readily soluble in hexane, ether, THF, CH2Cl2, benzene.
form: Viscous Liquid or Low Melting Solid
pka: 1.47±0.10(Predicted)
Specific Gravity: 1.303
color: Clear colorless or white
optical activity: [α]20/D 73±1°, c = 2% in methanol
Sensitive: Hygroscopic
Merck: 14,6280
BRN: 3591561
CAS DataBase Reference: 17257-71-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
F: 3-10
Hazard Note: Irritant/Keep Cold
HazardClass: IRRITANT, HYGROSCOPIC, KEEP COLD
HS Code: 29189900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 318035
Product name: (S)-(?)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid
Purity: ≥99%
Packaging: 250mg
Price: $80.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: 318035
Product name: (S)-(?)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid
Purity: ≥99%
Packaging: 1g
Price: $170
Updated: 2024/03/01

Sigma-Aldrich

Product number: 65369
Product name: (S)-(−)-α-Methoxy-α-trifluoromethylphenylacetic acid
Purity: for chiral derivatization, LiChropur?, ≥99.0%
Packaging: 250mg
Price: $162
Updated: 2022/05/15

TCI Chemical

Product number: M0832
Product name: (S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic Acid [Optical Resolving]
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $187
Updated: 2024/03/01

TCI Chemical

Product number: M0832
Product name: (S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic Acid [Optical Resolving]
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $693
Updated: 2024/03/01

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(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid Chemical Properties,Usage,Production

Chemical Properties

clear colorless viscous liquid

Uses

(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid is used as a chiral derivatizing agent, it reacts with an alcohol or amine of unknown stereochemistry to form an ester or amide. The absolute configuration of the ester or amide is then determined by proton and/or 19F NMR spectroscopy.

General Description

(S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid is commonly used as a derivatizing agent in Mosher ester analysis and Mosher amide analysis, which are NMR-based methods for determining the absolute configuration of the chiral carbon center in secondary alcohols and amines, respectively.

Purification Methods

A likely impurity is phenylethylamine from the resolution. Dissolve the acid in Et2O/*benzene (3:1), wash with 0.5N H2SO4, then water, dry over magnesium sulfate, filter, evaporate and distil it. [Dale et al. J Org Chem 34 2543 1969, J Am Chem Soc 75 512 1973.]

(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid Suppliers

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View Lastest Price from (S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: (S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid >=99% 17257-71-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

17257-71-5, (S)-(-)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acidRelated Search:

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(S)-(-)-alpha-Methoxy-alpha-(trifluoroMethyl)phenylacetic acid, 98% 250MG

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(S)-(-)-α-Methoxy-α-(trifluoromethyl)phenylacetic acid

17257-71-5

Asymmetric Synthesis

Derivatization Reagents

Chiral Resolving Reagents

Chiral Resolution Reagents

Analytical Chromatography Product Catalog

Chiral Derivatization

e.e. / Absolute Conefiguration Determination (NMR)

Enantiomer Excess & Absolute Conefiguration Determination

Analytical Chemistry