ChemicalBook > CAS DataBase List > H-ALA-TYR-PRO-GLY-LYS-PHE-NH2

H-ALA-TYR-PRO-GLY-LYS-PHE-NH2

Product Name
H-ALA-TYR-PRO-GLY-LYS-PHE-NH2
CAS No.
352017-71-1
Chemical Name
H-ALA-TYR-PRO-GLY-LYS-PHE-NH2
Synonyms
AY-NH;AY-NH2;PAR4-AP;AYPGKF-NH2;AYPGKFAMIDE;PAR-4 aMide, Mouse;PAR-4 AGONIST AMIDE;Allantoin Impurity 3;ALA-TYR-PRO-GLY-LYS-PHE-NH2;PAR-4 Agonist Peptide, amide
CBNumber
CB9174223
Molecular Formula
C34H48N8O7
Formula Weight
680.79
MOL File
352017-71-1.mol
More
Less

H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 Property

Boiling point:
1143.1±65.0 °C(Predicted)
Density 
1.285±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
Soluble in H2O
form 
solid
pka
9.84±0.15(Predicted)
color 
White to off-white
Water Solubility 
Soluble in water
More
Less

Safety

Safety Statements 
22-24/25
WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Alfa Aesar
Product number
J66921
Product name
Selective Protease-Activated Receptor 4 (PAR4) Agonist
Packaging
1mg
Price
$65.9
Updated
2023/06/20
Alfa Aesar
Product number
J66921
Product name
Selective Protease-Activated Receptor 4 (PAR4) Agonist
Packaging
5mg
Price
$212
Updated
2021/12/16
Tocris
Product number
1487
Product name
AY-NH2
Packaging
1
Price
$309
Updated
2021/12/16
TRC
Product number
A795103
Product name
AY-NH2
Packaging
1mg
Price
$280
Updated
2021/12/16
Usbiological
Product number
254695
Product name
AY-NH2
Packaging
1mg
Price
$573
Updated
2021/12/16
More
Less

H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 Chemical Properties,Usage,Production

Uses

AY-NH2 is used in the synthetic preparation of PAR4 agonist peptides towards PAR4 receptor activation.

Biological Activity

ay-nh2 is a selective agonist of par4 with ec50 value of 11 μm [1].protease-activated receptor-4 (par4) is a member of pars and plays an important role in mediating cellular effects of thrombin through acting g-proteins i, 12/13 (rho and ras activation) and q (calcium signaling) [2].ay-nh2 is a potent par4 agonist and has a higher (~10 fold) activity than gypgkf-nh2. using rat platelet aggregation assay, it was shown that ay-nh2 had highly platelet aggregation ability than gy-nh2 and gf-nh2 [1]. when tested with platelet-rich plasma harvested from wild-type c57bl6 mice, ay-nh2 treatment exhibited highly agonist activity on par4 while had no effect on other pars [3].in male wistar rats model of paw oedema, i.pl. injection of ay-nh2 markedly reduced the nociceptive score in response to both noxious and non-noxious mechanical stimuli, thus inhibiting carrageenan-induced mechanical hyperalgesia and allodynia [4].

storage

Store at -20°C

References

[1]. hollenberg, m.d., et al., proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. br j pharmacol, 2004. 143(4): p. 443-54.
[2]. yu, g., et al., increased expression of protease-activated receptor 4 and trefoil factor 2 in human colorectal cancer. plos one, 2015. 10(4): p. e0122678.
[3]. faruqi, t.r., et al., structure-function analysis of protease-activated receptor 4 tethered ligand peptides. determinants of specificity and utility in assays of receptor function. j biol chem, 2000. 275(26): p. 19728-34.
[4]. asfaha, s., et al., protease-activated receptor-4: a novel mechanism of inflammatory pain modulation. br j pharmacol, 2007. 150(2): p. 176-85.

H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 Suppliers

China 64 Europe 1 Germany 2 Switzerland 1 The Netherlands 1 United Kingdom 3 United States 12 Global 84
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
Country
China
ProdList
9981
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29785
Advantage
68
Nanjing Leon Biological Technology Co., Ltd.
Tel
17705183659
Fax
84523390
Email
sales@njleonbiotech.com
Country
China
ProdList
5501
Advantage
55
Nanjing Peptide Biotech Ltd.
Tel
025-025-58361106-805-805 13082558573
Fax
025-58361106-806
Email
liugang@njpeptide.com
Country
China
ProdList
9980
Advantage
55
Chengdu Youngshe Chemical Co., Ltd.
Tel
+86-17380623303 +86-17380623303
Fax
028-62328193
Email
Caroline@youngshechem.com
Country
China
ProdList
4814
Advantage
58
Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Fax
0571-87213919
Email
Eric@peptidego.com
Country
China
ProdList
6968
Advantage
58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
Tel
meitaochem@126.com
Email
meitaochem@126.com
Country
China
ProdList
19103
Advantage
58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471 +1-2135480471
Email
sales@sarms4muscle.com
Country
China
ProdList
10473
Advantage
58
Hangzhou Go Top Peptide Biotech
Tel
0571-88211921
Email
sales1@gotopbio.com
Country
CHINA
ProdList
2609
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9409
Advantage
58
Chengdu Peter-like Biotechnology Co., Ltd.
Tel
028-81700200 18108052721
Email
2850505130@qq.com
Country
China
ProdList
5176
Advantage
58
Shanghai Longyu Biotechnology Co., Ltd.
Tel
+8619521488211
Fax
+86 15821988213
Email
info@longyupharma.com
Country
China
ProdList
2541
Advantage
58
career henan chemical co
Tel
+86-0371-86658258 +8613203830695
Fax
0086-371-86658258
Email
factory@coreychem.com
Country
China
ProdList
29811
Advantage
58
Nanjing chengqimei Biotechnology Co., Ltd
Tel
19850819832
Email
2173594524@qq.com
Country
China
ProdList
2638
Advantage
58
Nanchang Tianzhen Biotechnology Co., Ltd
Tel
13173652190
Email
pomy@tanzhenbio.com
Country
China
ProdList
1785
Advantage
58
Wuxi Helen Biotechnology Co., Ltd.,
Tel
0510-85629785 18013409632
Fax
0510-85625359
Email
sales@reading-chemicals.com
Country
China
ProdList
14081
Advantage
58
Nanjing TGpeptide Biotechnology Co.,Ltd.
Tel
18115476705
Email
sales@tgpeptide.com
Country
China
ProdList
3058
Advantage
58
Ontores Biotech
Tel
0571-88760729 18072970094
Email
supports@ontorespeptide.com
Country
China
ProdList
2696
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44806
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58
DONBOO AMINO ACID COMPANY
Tel
+8613063595538
Email
donboo@donboo.com
Country
China
ProdList
9363
Advantage
58
TCI (Shanghai) Chemical Trading Co., Ltd.
Tel
021-021-61109150
Fax
021-61105897
Email
sales@tcisct.com
Country
China
ProdList
31121
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
13675144456
Email
alan.chow@synzest.com
Country
China
ProdList
9470
Advantage
58
Shaoxing Junyu Biotechnology Co., LTD
Tel
0571-88211921 15572296305
Email
sales4@gotopbio.com
Country
China
ProdList
5178
Advantage
58
Hangzhou Sinoda Pharmaceutical Technology Co. LTD
Tel
0571-87213919 17306812703
Email
3007955328@qq.com
Country
China
ProdList
6659
Advantage
58
Shanghai HongTide Biotechnology Co.,Ltd.
Tel
19961912513
Email
sales@hongtide.com
Country
China
ProdList
4600
Advantage
58
Zhongke Huayao (Jiangsu) Biotechnology Co., Ltd
Tel
13770887460
Email
wenxi@jszkhy.com
Country
China
ProdList
1351
Advantage
58
https://hanhongsci.com/
Tel
021-54306202 18917919676
Email
info@hanhongsci.com
Country
China
ProdList
29979
Advantage
58
Shanghai Toyang Biotechnology Co., LTD
Tel
021-59555769 13524932310
Fax
021-50342869
Email
1405894150@qq.com
Country
China
ProdList
8221
Advantage
58
Hubei De'ao Chemical Research Pharmaceutical Technology Co., Ltd
Tel
18502726233; 18502726233
Email
3641133981@qq.com
Country
China
ProdList
9711
Advantage
58
Nanjing Yushengkang Biotechnology Co., Ltd
Tel
13327808530
Email
2670965693@qq.com
Country
China
ProdList
2179
Advantage
58
Zhejiang Jiekun Biotechnology Co., Ltd
Tel
0571-88211951 13735575465
Email
sales1@gotopbio.com
Country
China
ProdList
4904
Advantage
58
Wuhan Peptide Core Biotechnology Co., Ltd
Tel
027-65317797 13667154760
Email
1096814016@qq.com
Country
China
ProdList
10120
Advantage
58
Taiyuan Bailihengkang Biotechnology Co., Ltd
Tel
19135651983 19135651983
Email
18611134419@163.com
Country
China
ProdList
4416
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
Country
China
ProdList
12005
Advantage
58
Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel
+86-18521732826
Email
market@aladdin-e.com
Country
China
ProdList
48461
Advantage
58
Changsha MOL Changes Biotechnology Co., Ltd.
Tel
+8619375158599
Email
info@molchanges.com
Country
China
ProdList
5223
Advantage
58
Zhejiang Hangyu API Co., Ltd
Tel
+8617531972939
Email
anna@api-made.com
Country
China
ProdList
2943
Advantage
58
Nanjing TGpeptide
Tel
+86-13347807150 +86-13347807150
Email
support@tgpeptide.com
Country
China
ProdList
3279
Advantage
58
Hebei Miaoyin Technology Co.,Ltd
Tel
+86-17367732028 +86-17367732028
Email
kathy@hbyinsheng.com
Country
China
ProdList
3512
Advantage
58
Chengdu Youngshe Chemical Co., Ltd.
Tel
+8618108235634
Email
Cecilia@youngshechem.com
Country
China
ProdList
2345
Advantage
58
Beijing Taize Jiaye Technology Development Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6050
Advantage
58
Beijing Dongge Boye Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1861586486@qq.com
Country
CHINA
ProdList
6648
Advantage
58
Shanghai Jie Ni Tai Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
service@genicbio.cn
Country
CHINA
ProdList
211
Advantage
58
More
Less

View Lastest Price from H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 manufacturers

Career Henan Chemical Co
Product
H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 352017-71-1
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-02-16
Career Henan Chemical Co
Product
H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 352017-71-1
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-02-16

352017-71-1, H-ALA-TYR-PRO-GLY-LYS-PHE-NH2Related Search:

H-GLY-TYR-PRO-GLY-LYS-PHE-NH2 H-SER-LEU-ILE-GLY-ARG-LEU-OH H-GLY-TYR-PRO-GLY-GLN-VAL-OH PAR-4 (1-6) amide (human) H-SER-LEU-ILE-GLY-ARG-LEU-NH2 COAGULATION FACTOR II RECEPTOR-LIKE 2 (1-6) AMIDE (HUMAN) VKGILS-NH2 COAGULATION FACTOR II RECEPTOR-LIKE 2 (1-6) AMIDE (MOUSE) PROTEASE Thrombin H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 ALA-TYR-PRO-GLY-LYS-PHE-NH2 TRIFLUOROACETATE SALT

  • PROTEASE-ACTIVATED RECEPTOR-4 AGONIST AMIDE
  • PAR-4 AGONIST AMIDE
  • H-ALA-TYR-PRO-GLY-LYS-PHE-NH2
  • AY-NH2
  • AYPGKFAMIDE
  • AYPGKF-NH2
  • (ALA1)-COAGULATION FACTOR II RECEPTOR-LIKE 3 (1-6) AMIDE (MOUSE)
  • (Ala1)-PAR-4 (1-6) amide (mouse) trifluoroacetate salt H-Ala-Tyr-Pro-Gly-Lys-Phe-NH2 trifluoroacetate salt
  • PAR-4 Agonist Peptide, amide (PAR-4-AP
  • AY-NH2;PAR4-AP;PROTEINASE-ACTIVATED RECEPTOR 4 ACTIVATING PEPTIDE
  • Proteinase-Activated Receptor 4 Activating Peptide
  • (2S)-N-[2-[[(2S)-6-amino-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxohexan-2-yl]amino]-2-oxoethyl]-1-[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carboxamide
  • PAR-4 Agonist Peptide, amide(2TFA)
  • AY-NH
  • (ALA1)-PROTEINASE ACTIVATED RECEPTOR 4 (1-6) AMIDE (MOUSE)
  • (ALA1)-PAR-4 (1-6) AMIDE (MOUSE)
  • (ALA1)-THROMBIN RECEPTOR-LIKE 3 (1-6) AMIDE (MOUSE)
  • ALA-TYR-PRO-GLY-LYS-PHE-NH2
  • Proteinase activated receptor 4 amide, mouse
  • AYPGKFaMide, (Ala1)-ThroMbin Receptor-Like 3 (1-6) aMide (Mouse), (Ala1)-Coagulation Factor II Receptor-Like 3 (1-6) aMide (Mouse), (Ala1)-Proteinase Activated Receptor 4 (1-6) aMide (Mouse)
  • PAR-4 aMide, Mouse
  • PAR4-AP
  • PAR-4 Agonist Peptide, amide
  • AYPGKF-NH2 Selective Protease-Activated Receptor 4 (PAR4) Agonist
  • Protease-Activated Receptor-4, PAR-4 Agonist, amide
  • L-Phenylalaninamide, L-alanyl-L-tyrosyl-L-prolylglycyl-L-lysyl-
  • Ala-Tyr-Pro-Gly-Lys-Phe-NH2 trifluoroacetate salt >=98% (HPLC), solid
  • 352017-71-1/1228078-65-6（TFA）
  • (Ala?)-PAR-4 (1-6) amide (mouse) trifluoroacetate salt
  • (Ala1)-PAR-4 (1-6)) amide (mouse)|[Ala1]-Protease Activated Receptor-4 (1-6) amide, mouse
  • AY-NH2 trifluoroacetate salt
  • Allantoin Impurity 3
  • 352017-71-1
  • Immunomodulators and Antibiotics
  • Immune Cell Signaling and Blood
  • Immune System Regulation
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • peptide
  • Peptide Receptors
  • Proteinase-activated receptor (PAR)