H-ALA-TYR-PRO-GLY-LYS-PHE-NH2
- Product Name
- H-ALA-TYR-PRO-GLY-LYS-PHE-NH2
- CAS No.
- 352017-71-1
- Chemical Name
- H-ALA-TYR-PRO-GLY-LYS-PHE-NH2
- Synonyms
- AY-NH;AY-NH2;PAR4-AP;AYPGKF-NH2;AYPGKFAMIDE;PAR-4 aMide, Mouse;PAR-4 AGONIST AMIDE;Allantoin Impurity 3;ALA-TYR-PRO-GLY-LYS-PHE-NH2;PAR-4 Agonist Peptide, amide
- CBNumber
- CB9174223
- Molecular Formula
- C34H48N8O7
- Formula Weight
- 680.79
- MOL File
- 352017-71-1.mol
H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 Property
- Boiling point:
- 1143.1±65.0 °C(Predicted)
- Density
- 1.285±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- Soluble in H2O
- form
- solid
- pka
- 9.84±0.15(Predicted)
- color
- White to off-white
- Water Solubility
- Soluble in water
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- J66921
- Product name
- Selective Protease-Activated Receptor 4 (PAR4) Agonist
- Packaging
- 1mg
- Price
- $65.9
- Updated
- 2023/06/20
- Product number
- J66921
- Product name
- Selective Protease-Activated Receptor 4 (PAR4) Agonist
- Packaging
- 5mg
- Price
- $212
- Updated
- 2021/12/16
- Product number
- 1487
- Product name
- AY-NH2
- Packaging
- 1
- Price
- $309
- Updated
- 2021/12/16
- Product number
- A795103
- Product name
- AY-NH2
- Packaging
- 1mg
- Price
- $280
- Updated
- 2021/12/16
- Product number
- 254695
- Product name
- AY-NH2
- Packaging
- 1mg
- Price
- $573
- Updated
- 2021/12/16
H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 Chemical Properties,Usage,Production
Uses
AY-NH2 is used in the synthetic preparation of PAR4 agonist peptides towards PAR4 receptor activation.
Biological Activity
ay-nh2 is a selective agonist of par4 with ec50 value of 11 μm [1].protease-activated receptor-4 (par4) is a member of pars and plays an important role in mediating cellular effects of thrombin through acting g-proteins i, 12/13 (rho and ras activation) and q (calcium signaling) [2].ay-nh2 is a potent par4 agonist and has a higher (~10 fold) activity than gypgkf-nh2. using rat platelet aggregation assay, it was shown that ay-nh2 had highly platelet aggregation ability than gy-nh2 and gf-nh2 [1]. when tested with platelet-rich plasma harvested from wild-type c57bl6 mice, ay-nh2 treatment exhibited highly agonist activity on par4 while had no effect on other pars [3].in male wistar rats model of paw oedema, i.pl. injection of ay-nh2 markedly reduced the nociceptive score in response to both noxious and non-noxious mechanical stimuli, thus inhibiting carrageenan-induced mechanical hyperalgesia and allodynia [4].
storage
Store at -20°C
References
[1]. hollenberg, m.d., et al., proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. br j pharmacol, 2004. 143(4): p. 443-54.
[2]. yu, g., et al., increased expression of protease-activated receptor 4 and trefoil factor 2 in human colorectal cancer. plos one, 2015. 10(4): p. e0122678.
[3]. faruqi, t.r., et al., structure-function analysis of protease-activated receptor 4 tethered ligand peptides. determinants of specificity and utility in assays of receptor function. j biol chem, 2000. 275(26): p. 19728-34.
[4]. asfaha, s., et al., protease-activated receptor-4: a novel mechanism of inflammatory pain modulation. br j pharmacol, 2007. 150(2): p. 176-85.
H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 Preparation Products And Raw materials
Raw materials
Preparation Products
H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 Suppliers
- Tel
- --
- Fax
- --
- info@labinova.se
- Country
- Europe
- ProdList
- 281
- Advantage
- 64
View Lastest Price from H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 manufacturers
- Product
- H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 352017-71-1
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-02-16
- Product
- H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 352017-71-1
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-02-16