ChemicalBook > CAS DataBase List > Thrombin

Thrombin

Product Name
Thrombin
CAS No.
9002-04-4
Chemical Name
Thrombin
Synonyms
C00752;BOVINE THROMBIN;THROMBIN;FACTOR IIA;EC 3.4.21.5;Thrombin RS;thrombin time;THROMBIN, BOVINE;Thrombin(Porcine);Thrombin USP/EP/BP
CBNumber
CB3387359
Molecular Formula
NULL
Formula Weight
0
MOL File
Mol file
More
Less

Thrombin Property

Melting point:
47.7 °C
storage temp. 
-20°C
solubility 
H2O: 1 mL/vial clear to slightly hazy, colorless solution
form 
powder
color 
white
Merck 
13,9461
EPA Substance Registry System
Thrombin (9002-04-4)
More
Less

Safety

Hazard Codes 
Xn,B,Xi
Risk Statements 
36/37/38-42
Safety Statements 
22-24/25-36/37-26-24
WGK Germany 
2
RTECS 
XO8950000
TSCA 
Yes
HS Code 
30021099
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T7572
Product name
Thrombin from human plasma
Purity
400-1000?NIH units/mg protein
Packaging
250units
Price
$201
Updated
2024/03/01
Sigma-Aldrich
Product number
T7572
Product name
Thrombin from human plasma
Purity
400-1000?NIH units/mg protein
Packaging
1000units
Price
$352.2
Updated
2024/03/01
Sigma-Aldrich
Product number
T7326
Product name
Thrombin from bovine plasma
Purity
≥60?NIH units/mg protein (biuret)
Packaging
1000units
Price
$73.9
Updated
2024/03/01
Sigma-Aldrich
Product number
T7326
Product name
Thrombin from bovine plasma
Purity
≥60?NIH units/mg protein (biuret)
Packaging
10000units
Price
$454
Updated
2024/03/01
Sigma-Aldrich
Product number
T4897
Product name
Thrombin from rabbit plasma
Packaging
25UNITS
Price
$656
Updated
2024/03/01
More
Less

Thrombin Chemical Properties,Usage,Production

Description

In order to stop local bleeding, thrombin, a natural thrombin drug that catalyzes the transformation of fibrinogen to fibrin, is frequently used. Thrombin is synthesized from cow plasma, and it is used to stop bleeding from open vessels when it is not possible to use other methods. It is used to stop light bleeding.

Uses

Thrombin is a trypsin-like serine protease involved in a multitude of processes in the human body. Thrombin generation is the result of limited proteolysis of the vitamin K-dependent zymogen prothrombin. Thrombin is the last enzyme in the clotting cascade functioning to cleave fibrinogen to fibrin which forms the fibrin gel of a haemostatic plug or a pathologic thrombus

Uses

Thrombostat (Parke-Davis).

Uses

Thrombin is used in coagulation research, medical research, protein-structure analysis, and biochemical research. It has been used for the stimulation of the platelets.

General Description

Thrombin is a sterile protein substanceprepared from prothrombin of bovine origin. It is used as atopical hemostatic because it can clot blood, plasma, or a solutionof fibrinogen without addition of other substances.Thrombin also may initiate clotting when combined withgelatin sponge or fibrin foam.
For external use it is applied topically to the wound, as asolution containing 100 to 2,000 National Institutes ofHealth (NIH) units/mL in sodium chloride irrigation or sterilewater for injection or as a dry powder.

Biochem/physiol Actions

The main function of thrombin is the cleavage of fibrinogen to fibrin, to assist stable clot formation. A wide range of mutations in the prothrombin gene contributes to its deficiency resulting in coagulation disorders like dysprothrombinemia and hypoprothrombinemia. High levels of thrombin elicit neurotoxicity in dopaminergic neurons and contributes to the progression of Parkinson′s disease. Altered thrombin levels modulates the coagulation pathway in multiple sclerosis. Patients with coronary artery disease (CAD) show elevated levels of thrombin. Thrombin accumulation in neurofibrillary tangles of the brain may contribute to the aggregation of tau protein and pathophysiology of Alzheimer disease.

Purification Methods

Thrombin is purified by chromatography on a DEAE-cellulose column, while eluting with 0.1M NaCl, pH 7.0, followed by chromatography on Sephadex G-200. The final preparation is free from plasminogen and plasmin. [Yin & Wessler J Biol Chem 243 112 1968.] Thrombin from bovine blood is also purified by chromatography using p-chlorobenzylamino--aminocaproyl agarose, and gel filtration through Sephadex G-25. [Thompson & Davie Biochim Biophys Acta 250 210 1971.] Thrombin from various species was purified initially by precipitation of impurities with rivanol. [Miller Nature 184 450 1959.] Tissue inhibitor of metalloproteins (TIMP, from human blood plasma), Mr ~30,000. These are purified by an [anti-human amniotic fluid-TIMP]-Sepharose immuno-affinity column and eluted with 50mM glycine/HCl pH 3.0 buffer that is 0.5M in NaCl, and followed by gel filtration [Cawston et al. Biochem J 238 677 1986].

Thrombin Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Thrombin Suppliers

Hunan Wokai Biotechnology Co., Ltd.
Tel
0744-2221508 13126795102
Fax
0744-6652010
Email
jack@oka-vip.com
Country
China
ProdList
317
Advantage
58
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4727
Advantage
58
Lingyuan Bebiansen Biological Technology Co., Ltd
Tel
18642120371
Email
2837458851@qq.com
Country
China
ProdList
7995
Advantage
58
Shanghai Baoman Biotechnology Co., Ltd.
Tel
021-62130998
Fax
021-54438215
Email
baomanbio@163.com
Country
China
ProdList
108
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8418
Advantage
55
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
More
Less

View Lastest Price from Thrombin manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Thrombin 9002-04-4
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20kg/month
Release date
2021-07-20
Shaanxi TNJONE Pharmaceutical Co., Ltd
Product
Thrombin 9002-04-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000kg
Release date
2024-05-15
Shaanxi Dideu Medichem Co. Ltd
Product
Thrombin 9002-04-4
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%+
Supply Ability
1000 tons
Release date
2020-01-02

9002-04-4, ThrombinRelated Search:


  • Blood coagulation factor IIa
  • C00752
  • Thrombin from human plasma,Factor IIa
  • Thrombin from murine plasma,Factor IIa
  • Thrombin from bovine plasma,Factor IIa
  • THROMBIN
  • THROMBIN, BOVINE
  • ThroMbin froM bovine plasMa 1000 units/Mg protein lyophil.
  • BOVINE THROMBIN
  • COAGULATION FACTOR IIA
  • EC 3.4.21.5
  • FACTOR IIA
  • thrombin from human plasma
  • thrombin time
  • Thrombin, Citrate-Free, HumanPlasma
  • Thrombin, Plasminogen-Free, Bovine
  • THROMBIN, RECOMBINANT HUMAN
  • THROMBIN FROM HUMAN PLASMA, >150 U/MG, PGE. WITH 100 MYL*
  • THROMBIN FROM BOVINE PLASMA CELL*CULTURE TESTED
  • THROMBIN FROM BOVINE PLASMA, ~1 U/MG*
  • THROMBIN ,FROM RABBIT PLASMA
  • Thrombin from bovine plasma
  • THROMBIN FROM HUMAN PLASMA, LYOPH., ~0.8 U/MG
  • thrombin from murine plasma
  • Factor IIa, Thrombin from human plasma
  • Blood coagulation factor II, activated
  • Thrombin, 2000 u/mg
  • Thrombin RS
  • Thrombin, from Bovine Plasma, Australia/New Zealand Origin
  • Thrombin USP/EP/BP
  • Factor Iia Thrombin
  • Thrombin(Factor IIa)
  • Thrombin (MW 37kDa)
  • Thrombin(Porcine)
  • Bovine Thrombin High Specific Activity
  • from Bovine Plasma ≥2000u/mg Thrombin
  • 9002-04-4
  • 9002-4-4
  • Fusion Protein Cleavage
  • Enzymes, Inhibitors, and Substrates
  • Clotting Factors
  • Proteases & Protein Sequencing
  • Immune Cell Signaling and Blood
  • Thrombins
  • Blood
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Application Index
  • Analytical Enzymes
  • Biochemicals and Reagents
  • BioChemical
  • proteins