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Thrombin

Product Name
Thrombin
CAS No.
9002-04-4
Chemical Name
Thrombin
Synonyms
C00752;THROMBIN;FACTOR IIA;EC 3.4.21.5;Thrombin RS;thrombin time;BOVINE THROMBIN;THROMBIN, BOVINE;Thrombin fandachem;Thrombin USP/EP/BP
CBNumber
CB3387359
Molecular Formula
NULL
Formula Weight
0
MOL File
Mol file
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Thrombin Property

Melting point:
47.7 °C
storage temp. 
-20°C
solubility 
H2O: 1 mL/vial clear to slightly hazy, colorless solution
form 
powder
color 
white
Merck 
13,9461
EPA Substance Registry System
Thrombin (9002-04-4)
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Safety

Hazard Codes 
Xn,B,Xi
Risk Statements 
36/37/38-42
Safety Statements 
22-24/25-36/37-26-24
WGK Germany 
2
RTECS 
XO8950000
TSCA 
Yes
HS Code 
30021099
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P284Wear respiratory protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T7572
Product name
Thrombin from human plasma
Purity
400-1000?NIH units/mg protein
Packaging
250 units
Price
$160
Updated
2021/03/22
Sigma-Aldrich
Product number
605160
Product name
Thrombin, Plasminogen-Free, Bovine
Packaging
1ku
Price
$161.87
Updated
2021/03/22
Sigma-Aldrich
Product number
T7572
Product name
Thrombin from human plasma
Purity
400-1000 NIH units/mg protein
Packaging
250un
Price
$228
Updated
2020/08/18
Sigma-Aldrich
Product number
T7326
Product name
Thrombin from bovine plasma
Purity
≥60?NIH units/mg protein (biuret)
Packaging
1000 units
Price
$54.3
Updated
2021/03/22
Sigma-Aldrich
Product number
T1063
Product name
Thrombin from human plasma
Purity
lyophilized powder, ≥2800?NIH units/mg protein (E1%/280, 18.3)
Packaging
250 units
Price
$255
Updated
2021/03/22
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Thrombin Chemical Properties,Usage,Production

Description

In order to stop local bleeding, thrombin, a natural thrombin drug that catalyzes the transformation of fibrinogen to fibrin, is frequently used. Thrombin is synthesized from cow plasma, and it is used to stop bleeding from open vessels when it is not possible to use other methods. It is used to stop light bleeding.

Uses

Thrombostat (Parke-Davis).

General Description

Thrombin is a sterile protein substanceprepared from prothrombin of bovine origin. It is used as atopical hemostatic because it can clot blood, plasma, or a solutionof fibrinogen without addition of other substances.Thrombin also may initiate clotting when combined withgelatin sponge or fibrin foam.
For external use it is applied topically to the wound, as asolution containing 100 to 2,000 National Institutes ofHealth (NIH) units/mL in sodium chloride irrigation or sterilewater for injection or as a dry powder.

Purification Methods

Thrombin is purified by chromatography on a DEAE-cellulose column, while eluting with 0.1M NaCl, pH 7.0, followed by chromatography on Sephadex G-200. The final preparation is free from plasminogen and plasmin. [Yin & Wessler J Biol Chem 243 112 1968.] Thrombin from bovine blood is also purified by chromatography using p-chlorobenzylamino--aminocaproyl agarose, and gel filtration through Sephadex G-25. [Thompson & Davie Biochim Biophys Acta 250 210 1971.] Thrombin from various species was purified initially by precipitation of impurities with rivanol. [Miller Nature 184 450 1959.] Tissue inhibitor of metalloproteins (TIMP, from human blood plasma), Mr ~30,000. These are purified by an [anti-human amniotic fluid-TIMP]-Sepharose immuno-affinity column and eluted with 50mM glycine/HCl pH 3.0 buffer that is 0.5M in NaCl, and followed by gel filtration [Cawston et al. Biochem J 238 677 1986].

Thrombin Preparation Products And Raw materials

Raw materials

Preparation Products

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Thrombin Suppliers

Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999- ;0411-62910999-
Email
sales@meilune.com;sales@meilune.com
Country
China
ProdList
3753
Advantage
58
Lingyuan Bebiansen Biological Technology Co., Ltd
Tel
Email
2837458851@qq.com
Country
China
ProdList
10002
Advantage
58
Hunan Wokai Biotechnology Co., Ltd.
Tel
0744-6652010-
Fax
0744-6652010
Email
2577930172@qq.com
Country
China
ProdList
169
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15877
Advantage
69
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057-
Fax
0757-86311057
Email
sales.gd@hwrkchemical.com
Country
China
ProdList
17295
Advantage
55
Chengdu XiYa Chemical Technology Co., Ltd.
Tel
;
Fax
0539-6365991
Email
sale@xiyashiji.com;3007716753@qq.com
Country
China
ProdList
10578
Advantage
57
BEST-REAGENT
Tel
400-1166-196;028-84555506- ;028-84555506-
Email
cdhxsj@163.com;1955352637@qq.com;cdhxsj@163.com
Country
China
ProdList
11718
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9844
Advantage
79
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065-
Email
3002732518@qq.com
Country
China
ProdList
3503
Advantage
62
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View Lastest Price from Thrombin manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Thrombin 9002-04-4
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20kg/month
Release date
2021-07-20
Shaanxi Dideu Medichem Co. Ltd
Product
Thrombin 9002-04-4
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%+
Supply Ability
1000 tons
Release date
2020-01-02
career henan chemical co
Product
Thrombin 9002-04-4
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
1000kg
Release date
2018-12-25

9002-04-4, ThrombinRelated Search:


  • Blood coagulation factor IIa
  • C00752
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  • Thrombin from murine plasma,Factor IIa
  • Thrombin from bovine plasma,Factor IIa
  • THROMBIN
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  • BOVINE THROMBIN
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  • FACTOR IIA
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  • Thrombin fandachem
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  • 9002-04-4
  • 9002-4-4
  • Fusion Protein Cleavage
  • Enzymes, Inhibitors, and Substrates
  • Clotting Factors
  • Proteases & Protein Sequencing
  • Immune Cell Signaling and Blood
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  • Blood
  • Cell Biology
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  • Application Index
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  • BioChemical
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