Thrombin
- Product Name
- Thrombin
- CAS No.
- 9002-04-4
- Chemical Name
- Thrombin
- Synonyms
- C00752;BOVINE THROMBIN;THROMBIN;FACTOR IIA;EC 3.4.21.5;Thrombin RS;thrombin time;THROMBIN, BOVINE;Thrombin（Porcine）;Thrombin USP/EP/BP
- CBNumber
- CB3387359
- Molecular Formula
- NULL
- Formula Weight
- 0
- MOL File
- Mol file
Thrombin Property
- Melting point:
- 47.7 °C
- storage temp.
- -20°C
- solubility
- H2O: 1 mL/vial clear to slightly hazy, colorless solution
- form
- powder
- color
- white
- Merck
- 13,9461
- EPA Substance Registry System
- Thrombin (9002-04-4)
Safety
- Hazard Codes
- Xn,B,Xi
- Risk Statements
- 36/37/38-42
- Safety Statements
- 22-24/25-36/37-26-24
- WGK Germany
- 2
- RTECS
- XO8950000
- TSCA
- Yes
- HS Code
- 30021099
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T7572
- Product name
- Thrombin from human plasma
- Purity
- 400-1000?NIH units/mg protein
- Packaging
- 250units
- Price
- $201
- Updated
- 2024/03/01
- Product number
- T7572
- Product name
- Thrombin from human plasma
- Purity
- 400-1000?NIH units/mg protein
- Packaging
- 1000units
- Price
- $352.2
- Updated
- 2024/03/01
- Product number
- T7326
- Product name
- Thrombin from bovine plasma
- Purity
- ≥60?NIH units/mg protein (biuret)
- Packaging
- 1000units
- Price
- $73.9
- Updated
- 2024/03/01
- Product number
- T7326
- Product name
- Thrombin from bovine plasma
- Purity
- ≥60?NIH units/mg protein (biuret)
- Packaging
- 10000units
- Price
- $454
- Updated
- 2024/03/01
- Product number
- T4897
- Product name
- Thrombin from rabbit plasma
- Packaging
- 25UNITS
- Price
- $656
- Updated
- 2024/03/01
Thrombin Chemical Properties,Usage,Production
Description
In order to stop local bleeding, thrombin, a natural thrombin drug that catalyzes the transformation of fibrinogen to fibrin, is frequently used. Thrombin is synthesized from cow plasma, and it is used to stop bleeding from open vessels when it is not possible to use other methods. It is used to stop light bleeding.
Uses
Thrombin is a trypsin-like serine protease involved in a multitude of processes in the human body. Thrombin generation is the result of limited proteolysis of the vitamin K-dependent zymogen prothrombin. Thrombin is the last enzyme in the clotting cascade functioning to cleave fibrinogen to fibrin which forms the fibrin gel of a haemostatic plug or a pathologic thrombus
Uses
Thrombostat (Parke-Davis).
Uses
Thrombin is used in coagulation research, medical research, protein-structure analysis, and biochemical research. It has been used for the stimulation of the platelets.
General Description
Thrombin is a sterile protein substanceprepared from prothrombin of bovine origin. It is used as atopical hemostatic because it can clot blood, plasma, or a solutionof fibrinogen without addition of other substances.Thrombin also may initiate clotting when combined withgelatin sponge or fibrin foam.
For external use it is applied topically to the wound, as asolution containing 100 to 2,000 National Institutes ofHealth (NIH) units/mL in sodium chloride irrigation or sterilewater for injection or as a dry powder.
Biochem/physiol Actions
The main function of thrombin is the cleavage of fibrinogen to fibrin, to assist stable clot formation. A wide range of mutations in the prothrombin gene contributes to its deficiency resulting in coagulation disorders like dysprothrombinemia and hypoprothrombinemia. High levels of thrombin elicit neurotoxicity in dopaminergic neurons and contributes to the progression of Parkinson′s disease. Altered thrombin levels modulates the coagulation pathway in multiple sclerosis. Patients with coronary artery disease (CAD) show elevated levels of thrombin. Thrombin accumulation in neurofibrillary tangles of the brain may contribute to the aggregation of tau protein and pathophysiology of Alzheimer disease.
Purification Methods
Thrombin is purified by chromatography on a DEAE-cellulose column, while eluting with 0.1M NaCl, pH 7.0, followed by chromatography on Sephadex G-200. The final preparation is free from plasminogen and plasmin. [Yin & Wessler J Biol Chem 243 112 1968.] Thrombin from bovine blood is also purified by chromatography using p-chlorobenzylamino--aminocaproyl agarose, and gel filtration through Sephadex G-25. [Thompson & Davie Biochim Biophys Acta 250 210 1971.] Thrombin from various species was purified initially by precipitation of impurities with rivanol. [Miller Nature 184 450 1959.] Tissue inhibitor of metalloproteins (TIMP, from human blood plasma), Mr ~30,000. These are purified by an [anti-human amniotic fluid-TIMP]-Sepharose immuno-affinity column and eluted with 50mM glycine/HCl pH 3.0 buffer that is 0.5M in NaCl, and followed by gel filtration [Cawston et al. Biochem J 238 677 1986].
Thrombin Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Thrombin manufacturers
- Product
- Thrombin 9002-04-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20kg/month
- Release date
- 2021-07-20
- Product
- Thrombin 9002-04-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-05-15
- Product
- Thrombin 9002-04-4
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 1000 tons
- Release date
- 2020-01-02