ChemicalBook > CAS DataBase List > 4-BROMOPYRIDIN-2-OL

4-BROMOPYRIDIN-2-OL

Product Name
4-BROMOPYRIDIN-2-OL
CAS No.
36953-37-4
Chemical Name
4-BROMOPYRIDIN-2-OL
Synonyms
4-Bromo-2-pyridone;4-BROMOPYRIDIN-2-OL;4-BROMO-2-PYRIDINOL;4-Iodo-1H-pyridin-2-one;4-IODOPYRIDIN-2(1H)-ONE;4-Bromo-1H-pyridin-2-one;4-Iodoopyridin-2(1H)-one;4-Bromo-2(1H)-pyridinone;4-BROMO-2-HYDROXYPYRIDINE;2-HYDROXY-4-BROMOPYRIDINE
CBNumber
CB9175013
Molecular Formula
C5H4BrNO
Formula Weight
174
MOL File
36953-37-4.mol
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4-BROMOPYRIDIN-2-OL Property

Melting point:
186 °C
Boiling point:
305.9±42.0 °C(Predicted)
Density 
1.776±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
10.54±0.10(Predicted)
form 
Crystalline Powder
color 
White
InChI
InChI=1S/C5H4BrNO/c6-4-1-2-7-5(8)3-4/h1-3H,(H,7,8)
InChIKey
SSLMGOKTIUIZLY-UHFFFAOYSA-N
SMILES
C1(=O)NC=CC(Br)=C1
CAS DataBase Reference
36953-37-4(CAS DataBase Reference)
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Safety

Risk Statements 
36/38
Safety Statements 
36
Hazard Note 
Harmful
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B4383
Product name
4-Bromo-2-hydroxypyridine
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$122
Updated
2025/07/31
TRC
Product number
B686020
Product name
4-Bromo-2-hydroxypyridine
Packaging
2.5g
Price
$120
Updated
2021/12/16
TRC
Product number
B686020
Product name
4-Bromo-2-hydroxypyridine
Packaging
25g
Price
$580
Updated
2021/12/16
AK Scientific
Product number
W5808
Product name
4-Bromo-2-hydroxypyridine
Packaging
1g
Price
$14
Updated
2021/12/16
Apolloscientific
Product number
OR40285
Product name
4-Bromo-2-hydroxypyridine
Purity
99%
Packaging
1g
Price
$15
Updated
2021/12/16
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4-BROMOPYRIDIN-2-OL Chemical Properties,Usage,Production

Uses

4-Bromo-2-hydroxypyridine is used as a reagent to synthesize trans-3,4’-bispyridinylethylenes, compounds that act as inhibitors of protein kinase B that are used to treat cancer.

Synthesis

100367-39-3

36953-37-4

General procedure for the synthesis of 4-bromo-2-hydroxypyridine from 4-bromo-2-methoxypyridine: Step a: Preparation of 4-bromopyridin-2(1H)-one; To a solution of 1,4-dioxane (26 mL) of 4-bromo-2-methoxypyridine (1.0 g, 5.3 mmol) was added an aqueous 4M HCl solution (13 mL). The reaction mixture was heated at 90 °C for 5 h, followed by heating at 50 °C overnight. Upon completion of the reaction, it was neutralized to pH 8-9 with 1N NaOH solution and extracted with ethyl acetate. The organic phase was dried with anhydrous MgSO4 and concentrated to give 4-bromopyridin-2(1H)-one as a white solid (490 mg, 53% yield). The aqueous phase was concentrated and the residue was stirred with dichloromethane and filtered. The filtrate was concentrated to give additional 4-bromopyridin-2(1H)-one (320 mg, 35% yield).ESI-MS m/z calculated value 173.0, measured value 174.3 (M+1)+. Retention time 0.32 min. 1H NMR (400 MHz, DMSO-d6) δ 11.87 (s, 1H), 7.36 (d, J=7.0 Hz, 1H), 6.64 (d, J=2.0 Hz, 1H), 6.37 (dd, J=2.0,7.0 Hz, 1H).

References

[1] Patent: WO2008/141119, 2008, A2. Location in patent: Page/Page column 97
[2] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 21, p. 6262 - 6267

4-BROMOPYRIDIN-2-OL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-BROMOPYRIDIN-2-OL manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
4-BROMOPYRIDIN-2-OL 36953-37-4
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-11-29
Shaanxi Dideu New Materials Co. Ltd
Product
4-BROMOPYRIDIN-2-OL 36953-37-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-04-02
Hebei Zhanyao Biotechnology Co. Ltd
Product
4-BROMOPYRIDIN-2-OL 36953-37-4
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 Tons
Release date
2021-10-18

36953-37-4, 4-BROMOPYRIDIN-2-OLRelated Search:

4-BROMO-2-HYDROXYBENZONITRILE 2-FLUORO-3-BROMO-5-HYDROXYPYRIDINE 2-Chloro-3-Bromo-5-Hydroxypyridine Methyl 5-Bromo-2-hydroxypyridine-4-carboxylate, 5-Bromo-4-methoxycarbonyl-2(1H)-pyridinone 4-Amino-3-bromo-2-hydroxypyridine,4-Amino-3-bromopyridin-2-ol 4-BROMO-2-ETHOXYPYRIDINE 2-Bromo-3-hydroxypyridine 5-BROMO-6-HYDROXYPYRIDINE-3-CARBOXYLIC ACID 3-BROMO-5-HYDROXYPYRIDINE 98.5+%,5-Bromo-3-hydroxypyridine 5-Bromo-3-pyridinol,3-BROMO-5-HYDROXYPYRIDINE,5-BROMO-3-HYDROXYPYRIDINE 2-BROMO-5-HYDROXYPYRIDINE ,98%,6-BROMO-3-HYDROXYPYRIDINE,2-BROMO-5-HYDROXYPYRIDINE 4-BROMO-5-FLUORO-2-HYDROXY-3-NITROPYRIDINE 4-Bromo-2-methoxypyridine 4-BROMO-3-HYDROXYPYRIDINE,4-Bromopyridin-3-ol 2-amino-5-bromo-4-pyrimidinol 3-BROMO-2-HYDROXYPYRIDINE,3-Bromo-2-Hydroxypyridine99% 2-Bromopyridin-4-ol,2-BROMO-4-HYDROXYPYRIDINE 97% 3-Bromopyridin-4-ol,3-BROMO-4-HYDROXYPYRIDINE 97%,3-BROMO-4-HYDROXYPYRIDINE 3,5-DIBROMO-2-HYDROXYPYRIDINE

  • 4-Iodoopyridin-2(1H)-one
  • 4-BROMO-2-PYRIDINOL
  • 4-BROMO-2-HYDROXYPYRIDINE
  • 4-BROMOPYRIDIN-2-OL
  • 4-Iodo-1H-pyridin-2-one
  • 2-HYDROXY-4-BROMOPYRIDINE
  • 4-IODOPYRIDIN-2(1H)-ONE
  • 4-Iodo-1H-pyridin-2-one 97%
  • 4-BROMO-2-HYDROXYPYRIDINE 97%
  • 4-CYANO-3,5-DIFLUOROANISOLE
  • 4-Bromo-1H-pyridin-2-one
  • 4-Bromo-2(1H)-pyridinone
  • 4-Bromopyridin-2-ol, 4-Bromopyridin-2(1H)-one
  • 2(1H)-Pyridinone,4-broMo-
  • 4-BroMopyridin-2-ol, 98%+
  • 4-Bromo-2-hydroxypyridine,97%
  • 4-bromo-1,2-dihydropyridin-2-one
  • 4-Bromo-2-hydroxypyridine&gt
  • 4-Bromo-2-pyridone
  • 4-BROMOPYRIDIN-2-OL ISO 9001：2015 REACH
  • 36953-37-4
  • 3695-37-4
  • Heterocycle-Pyridine series
  • pharmacetical
  • Halides
  • Pyridines
  • Pyridine
  • Pyridine Series