4-BROMO-3-HYDROXYPYRIDINE
- Product Name
- 4-BROMO-3-HYDROXYPYRIDINE
- CAS No.
- 161417-28-3
- Chemical Name
- 4-BROMO-3-HYDROXYPYRIDINE
- Synonyms
- 4-Bromopyridin-3-ol;4-BROMO-3-PYRIDINOL;3-Pyridinol, 4-bromo-;4-boro-3-hydroxypyridine;4-BROMO-3-HYDROXYPYRIDINE;4-BROMO-3-HYDROXYOPYRIDINE;4-BROMO-3-HYDROXYPYRIDINE ISO 9001：2015 REACH
- CBNumber
- CB5147797
- Molecular Formula
- C5H4BrNO
- Formula Weight
- 174
- MOL File
- 161417-28-3.mol
4-BROMO-3-HYDROXYPYRIDINE Property
- Melting point:
- 134-136°C
- Boiling point:
- 316.2±22.0 °C(Predicted)
- Density
- 1.788±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Chloroform (Sparingly), Ethyl Acetate
- form
- Solid
- pka
- 6.57±0.10(Predicted)
- color
- White to Off-White
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- B684473
- Product name
- 4-Bromo-3-hydroxypyridine
- Packaging
- 250mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- B684473
- Product name
- 4-Bromo-3-hydroxypyridine
- Packaging
- 5g
- Price
- $525
- Updated
- 2021/12/16
- Product number
- OR301092
- Product name
- 4-Bromo-3-hydroxypyridine
- Purity
- 96%
- Packaging
- 10g
- Price
- $551
- Updated
- 2021/12/16
- Product number
- 4H01-9-04
- Product name
- 4-Bromo-3-hydroxypyridine
- Purity
- 96%
- Packaging
- 10g
- Price
- $608
- Updated
- 2021/12/16
- Product number
- CS-W006061
- Product name
- 4-Bromo-3-hydroxypyridine
- Purity
- 99.98%
- Packaging
- 25g
- Price
- $705
- Updated
- 2021/12/16
4-BROMO-3-HYDROXYPYRIDINE Chemical Properties,Usage,Production
Chemical Properties
White Solid
Synthesis
98976-81-9
161417-28-3
The general procedure for the synthesis of 4-bromo-3-hydroxypyridine from the compound (CAS: 98976-81-9) is as follows: to a solution of 4-bromo-3-pyridinyl diethylcarbamate (1.24 g, 4.50 mmol) in methanol (10 mL) was added methanolic solution of sodium methanolate (2.04 g, 9.40 mmol) at 20°C and the resulting mixture was refluxed for 1.5 hours. Upon completion of the reaction, methanol was removed by distillation under reduced pressure, ethyl acetate (15 mL) and water (1 mL) were added, and then the pH was adjusted to 9 with 20% aqueous sulfuric acid. the organic layer was separated, and the residue was washed with ethyl acetate (3 x 5 mL). The organic layers were combined, dried and concentrated with anhydrous sodium sulfate. The crude product was purified by rapid chromatography on silica gel, eluting sequentially with hexane/ethyl acetate (1:1 and 1:2) to give 691 mg (89% yield) of 4-bromo-3-hydroxypyridine.TLC Rf value was 0.38 (1:2 hexane/ethyl acetate). Mass spectra (DCI/NH3) m/e 174 (with 79 Br) and 176 (M+H)+ (with 81 Br).1H NMR (CDCl3, 300 MHz) δ: 8.43 (d, J=1.5 Hz, 1H, ArH), 8.02 (d, J=7.2 Hz, 1H, ArH), 7.54 (dd, J=7.2,1.5 Hz. 1H, ArH).
References
[1] Patent: US5914328, 1999, A
[2] Patent: US5948793, 1999, A
4-BROMO-3-HYDROXYPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-BROMO-3-HYDROXYPYRIDINE manufacturers
- Product
- 4-BROMO-3-HYDROXYPYRIDINE 161417-28-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-09-24
- Product
- 4-BROMO-3-HYDROXYPYRIDINE 161417-28-3
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2020-01-13