ChemicalBook > CAS DataBase List > 4-BROMOPYRIDIN-2-OL

4-BROMOPYRIDIN-2-OL

Product Name
4-BROMOPYRIDIN-2-OL
CAS No.
36953-37-4
Chemical Name
4-BROMOPYRIDIN-2-OL
Synonyms
4-Bromo-2-pyridone;4-BROMOPYRIDIN-2-OL;4-BROMO-2-PYRIDINOL;4-Iodo-1H-pyridin-2-one;4-IODOPYRIDIN-2(1H)-ONE;4-Bromo-1H-pyridin-2-one;4-Iodoopyridin-2(1H)-one;4-Bromo-2(1H)-pyridinone;4-BROMO-2-HYDROXYPYRIDINE;2-HYDROXY-4-BROMOPYRIDINE
CBNumber
CB9175013
Molecular Formula
C5H4BrNO
Formula Weight
174
MOL File
36953-37-4.mol
More
Less

4-BROMOPYRIDIN-2-OL Property

Melting point:
186 °C
Boiling point:
305.9±42.0 °C(Predicted)
Density 
1.776±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
10.54±0.10(Predicted)
form 
Crystalline Powder
color 
White
InChI
InChI=1S/C5H4BrNO/c6-4-1-2-7-5(8)3-4/h1-3H,(H,7,8)
InChIKey
SSLMGOKTIUIZLY-UHFFFAOYSA-N
SMILES
C1(=O)NC=CC(Br)=C1
CAS DataBase Reference
36953-37-4(CAS DataBase Reference)
More
Less

Safety

Risk Statements 
36/38
Safety Statements 
36
Hazard Note 
Harmful
HS Code 
29333990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
B4383
Product name
4-Bromo-2-hydroxypyridine
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$122
Updated
2025/07/31
TRC
Product number
B686020
Product name
4-Bromo-2-hydroxypyridine
Packaging
2.5g
Price
$120
Updated
2021/12/16
TRC
Product number
B686020
Product name
4-Bromo-2-hydroxypyridine
Packaging
25g
Price
$580
Updated
2021/12/16
SynQuest Laboratories
Product number
4H48-9-54
Product name
4-Bromo-1H-pyridin-2-one
Packaging
25g
Price
$192
Updated
2021/12/16
SynQuest Laboratories
Product number
4H48-9-54
Product name
4-Bromo-1H-pyridin-2-one
Packaging
5G
Price
$45
Updated
2021/12/16
More
Less

4-BROMOPYRIDIN-2-OL Chemical Properties,Usage,Production

Uses

4-Bromo-2-hydroxypyridine is used as a reagent to synthesize trans-3,4’-bispyridinylethylenes, compounds that act as inhibitors of protein kinase B that are used to treat cancer.

Synthesis

100367-39-3

36953-37-4

General procedure for the synthesis of 4-bromo-2-hydroxypyridine from 4-bromo-2-methoxypyridine: Step a: Preparation of 4-bromopyridin-2(1H)-one; To a solution of 1,4-dioxane (26 mL) of 4-bromo-2-methoxypyridine (1.0 g, 5.3 mmol) was added an aqueous 4M HCl solution (13 mL). The reaction mixture was heated at 90 °C for 5 h, followed by heating at 50 °C overnight. Upon completion of the reaction, it was neutralized to pH 8-9 with 1N NaOH solution and extracted with ethyl acetate. The organic phase was dried with anhydrous MgSO4 and concentrated to give 4-bromopyridin-2(1H)-one as a white solid (490 mg, 53% yield). The aqueous phase was concentrated and the residue was stirred with dichloromethane and filtered. The filtrate was concentrated to give additional 4-bromopyridin-2(1H)-one (320 mg, 35% yield).ESI-MS m/z calculated value 173.0, measured value 174.3 (M+1)+. Retention time 0.32 min. 1H NMR (400 MHz, DMSO-d6) δ 11.87 (s, 1H), 7.36 (d, J=7.0 Hz, 1H), 6.64 (d, J=2.0 Hz, 1H), 6.37 (dd, J=2.0,7.0 Hz, 1H).

References

[1] Patent: WO2008/141119, 2008, A2. Location in patent: Page/Page column 97
[2] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 21, p. 6262 - 6267

4-BROMOPYRIDIN-2-OL Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4-BROMOPYRIDIN-2-OL Suppliers

Americas 1 China 256 Europe 1 France 1 Germany 6 India 7 Japan 1 Switzerland 2 The Netherlands 1 United Kingdom 7 United States 29 Global 312
TCI Chemicals (India) Pvt. Ltd.
Tel
--
Fax
--
Email
sales-in@tcichemicals.com
Country
India
ProdList
6768
Advantage
58
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
India
ProdList
6905
Advantage
58
Reax Chemicals
Tel
--
Fax
--
Country
India
ProdList
4217
Advantage
58
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
Anax Laboratories
Tel
--
Fax
--
Email
info@anaxlab.com
Country
India
ProdList
177
Advantage
0
More
Less

View Lastest Price from 4-BROMOPYRIDIN-2-OL manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
4-BROMOPYRIDIN-2-OL 36953-37-4
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-11-29
Shaanxi Dideu New Materials Co. Ltd
Product
4-BROMOPYRIDIN-2-OL 36953-37-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-04-02
Hebei Zhanyao Biotechnology Co. Ltd
Product
4-BROMOPYRIDIN-2-OL 36953-37-4
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 Tons
Release date
2021-10-18

36953-37-4, 4-BROMOPYRIDIN-2-OLRelated Search:

4-BROMO-2-HYDROXYBENZONITRILE 2-FLUORO-3-BROMO-5-HYDROXYPYRIDINE 2-Chloro-3-Bromo-5-Hydroxypyridine Methyl 5-Bromo-2-hydroxypyridine-4-carboxylate, 5-Bromo-4-methoxycarbonyl-2(1H)-pyridinone 4-Amino-3-bromo-2-hydroxypyridine,4-Amino-3-bromopyridin-2-ol 4-BROMO-2-ETHOXYPYRIDINE 2-Bromo-3-hydroxypyridine 5-BROMO-6-HYDROXYPYRIDINE-3-CARBOXYLIC ACID 3-BROMO-5-HYDROXYPYRIDINE 98.5+%,5-Bromo-3-hydroxypyridine 5-Bromo-3-pyridinol,3-BROMO-5-HYDROXYPYRIDINE,5-BROMO-3-HYDROXYPYRIDINE 2-BROMO-5-HYDROXYPYRIDINE ,98%,6-BROMO-3-HYDROXYPYRIDINE,2-BROMO-5-HYDROXYPYRIDINE 4-BROMO-5-FLUORO-2-HYDROXY-3-NITROPYRIDINE 4-Bromo-2-methoxypyridine 4-BROMO-3-HYDROXYPYRIDINE,4-Bromopyridin-3-ol 2-amino-5-bromo-4-pyrimidinol 3-BROMO-2-HYDROXYPYRIDINE,3-Bromo-2-Hydroxypyridine99% 2-Bromopyridin-4-ol,2-BROMO-4-HYDROXYPYRIDINE 97% 3-Bromopyridin-4-ol,3-BROMO-4-HYDROXYPYRIDINE 97%,3-BROMO-4-HYDROXYPYRIDINE 3,5-DIBROMO-2-HYDROXYPYRIDINE

  • 4-Iodoopyridin-2(1H)-one
  • 4-BROMO-2-PYRIDINOL
  • 4-BROMO-2-HYDROXYPYRIDINE
  • 4-BROMOPYRIDIN-2-OL
  • 4-Iodo-1H-pyridin-2-one
  • 2-HYDROXY-4-BROMOPYRIDINE
  • 4-IODOPYRIDIN-2(1H)-ONE
  • 4-Iodo-1H-pyridin-2-one 97%
  • 4-BROMO-2-HYDROXYPYRIDINE 97%
  • 4-CYANO-3,5-DIFLUOROANISOLE
  • 4-Bromo-1H-pyridin-2-one
  • 4-Bromo-2(1H)-pyridinone
  • 4-Bromopyridin-2-ol, 4-Bromopyridin-2(1H)-one
  • 2(1H)-Pyridinone,4-broMo-
  • 4-BroMopyridin-2-ol, 98%+
  • 4-Bromo-2-hydroxypyridine,97%
  • 4-bromo-1,2-dihydropyridin-2-one
  • 4-Bromo-2-hydroxypyridine&gt
  • 4-Bromo-2-pyridone
  • 4-BROMOPYRIDIN-2-OL ISO 9001：2015 REACH
  • 36953-37-4
  • 3695-37-4
  • Heterocycle-Pyridine series
  • pharmacetical
  • Halides
  • Pyridines
  • Pyridine
  • Pyridine Series