ChemicalBook > CAS DataBase List > 3-Dimethylaminophenol

3-Dimethylaminophenol

Product Name
3-Dimethylaminophenol
CAS No.
99-07-0
Chemical Name
3-Dimethylaminophenol
Synonyms
3-n,n-dimethylaminophenol;DIMETHYLAMINOPHENOL;N,N-DIMETHYL-3-AMINOPHENOL;Phenol, 3-(dimethylamino)-;3-DMAP;M-DIMETHYLAMINOPHENOL;Neostigmine impurity B;NSC 62017;JACS-99-07-0;3-DIMETHYLAMINPHENOL
CBNumber
CB9177961
Molecular Formula
C8H11NO
Formula Weight
137.18
MOL File
99-07-0.mol
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3-Dimethylaminophenol Property

Melting point:
82-84 °C(lit.)
Boiling point:
265-268°C
Density 
1.0976 (rough estimate)
refractive index 
1.5895 (estimate)
Flash point:
148 °C
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Powder
pka
10.06±0.10(Predicted)
color 
violet
PH
7 (10g/l, H2O, 20℃)(slurry)
Water Solubility 
SLIGHTLY SOLUBLE
Sensitive 
Light Sensitive
BRN 
774631
Stability:
Stable. May be air-sensitive. Combustible. Incompatible with strong oxidizing agents.
InChIKey
MESJRHHDBDCQTH-UHFFFAOYSA-N
CAS DataBase Reference
99-07-0(CAS DataBase Reference)
NIST Chemistry Reference
Phenol, 3-(dimethylamino)-(99-07-0)
EPA Substance Registry System
m-(Dimethylamino)phenol (99-07-0)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-20/21/22
Safety Statements 
26-36-36/37/39-22
WGK Germany 
3
RTECS 
SL1050000
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29222900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D144002
Product name
3-(Dimethylamino)phenol
Purity
97%
Packaging
5g
Price
$57.6
Updated
2024/03/01
Sigma-Aldrich
Product number
D144002
Product name
3-(Dimethylamino)phenol
Purity
97%
Packaging
25g
Price
$118
Updated
2024/03/01
TCI Chemical
Product number
D0657
Product name
3-(Dimethylamino)phenol
Purity
>97.0%(GC)(T)
Packaging
25g
Price
$83
Updated
2024/03/01
TCI Chemical
Product number
D0657
Product name
3-(Dimethylamino)phenol
Purity
>97.0%(GC)(T)
Packaging
100g
Price
$224
Updated
2024/03/01
Alfa Aesar
Product number
B23067
Product name
3-Dimethylaminophenol, 97+%
Packaging
5g
Price
$31.65
Updated
2024/03/01
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3-Dimethylaminophenol Chemical Properties,Usage,Production

Chemical Properties

Brown to Purple Solid

Uses

3-Dimethylaminophenol can be used as neostigmine bromide intermediate and dye intermediate.

General Description

Needles (from ligroin) or a dark gray solid.

Air & Water Reactions

Sensitive to prolonged exposure to air. Insoluble in water.

Reactivity Profile

An amine and phenol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Phenols do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has Ka = 1.3 x 10^[-10]). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Such heating may initiate polymerization of the organic compound. Phenols are sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid.

Fire Hazard

Flash point data for 3-Dimethylaminophenol are not available. 3-Dimethylaminophenol is probably combustible.

Synthesis

3-Dimethylaminophenol is used to synthesize dyes and pharmaceutical intermediates. The traditional production process of this compound is to react m-aminophenol with dimethyl sulfate and then purify it in multiple steps to obtain 3-(N, N-dimethylamino)phenol. The production process requires highly toxic dimethyl sulfate, which has high requirements for safe production and raw material transportation and is not conducive to industrial production. Another method is to first react resorcinol with dimethylamine aqueous solution to obtain 3-(N, N-dimethylamino)phenol crude product, then add industrial liquid alkali to the crude product, and then add toluene to extract by-products. After neutralising the aqueous phase, wash to remove the unreacted resorcinol and then distil under reduced pressure to obtain 3-(N, N-dimethylamino)phenol. The operation is simple, the product purity is high, the raw materials are easy to store and transport, and it is easy to industrialize and produce safely.

3-Dimethylaminophenol Preparation Products And Raw materials

Raw materials

3-Aminophenol

Preparation Products

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3-Dimethylaminophenol Suppliers

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View Lastest Price from 3-Dimethylaminophenol manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
3-Dimethylaminophenol 99-07-0
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-11-07
Jinan Finer Chemical Co., Ltd
Product
3-Dimethylaminophenol 99-07-0
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
≥99%
Supply Ability
200mt/year
Release date
2021-07-28
Hebei Weibang Biotechnology Co., Ltd
Product
3-Dimethylaminophenol 99-07-0
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-28

99-07-0, 3-DimethylaminophenolRelated Search:

3-Chloroaniline N,N-Dimethyl-1,4-phenylenediamine ETHANE Dimethyl sulfide Dimethyl sulfoxide Dimethyl fumarate Dimethyl ether 3-Hydroxybenzoic acid 2,3,4-Trihydroxybenzoic acid 2,3-Dimethylaniline 3,4-Dimethylaniline N,N-Dimethylaniline 4-Aminophenol m-Toluidine N,N-Dimethylformamide Dimethyl phthalate 3-Aminophenol 3,5-Dihydroxybenzoic acid

  • N N DIMETHYL-M-AMINOPHENOL
  • N,N-DIMETHYL-M-HYDROXYANILINE
  • N,N-DIMETHYL-3-AMINOPHENOL
  • (3-Hydroxyphenyl)dimethylamine
  • 3-(dimethylamino)-pheno
  • JACS-99-07-0
  • 3-(Dimethylamlno)phenol
  • Phenol, m-(dimethylamino)-
  • 3-DIMETHYLAMINOPHENOL
  • M-DIMETHYLAMINOPHENOL
  • 3-Dimethylaminophenol, 97+%
  • Phenol, 3-amino-N,N-dimethyl
  • DIMETHYLAMINOPHENOL
  • NSC 62017
  • m-(N,N-Dimethylamino)phenol
  • 3-(Dimethylamino)phenol ,98%
  • 3-DMAP
  • 3-DiMethylaMinophenol, 97% 25GR
  • 3-DIMETHYLAMINPHENOL
  • Neostigmine Impurity 3
  • 3-Hydroxydimethylaminobenzene
  • 3-Hydroxy-N,N-dimethylaniline
  • 3-n,n-dimethylaminophenol
  • Neostigmine impurity B
  • m-(dimethylamino)-pheno
  • m-Hydroxydimethylaniline
  • Neostigmine EP Impurity B
  • 3-(Dimethylamino)phenol &gt
  • Phenol, 3-(dimethylamino)-
  • Neostigmine Impurity 2(Neostigmine EP Impurity B)
  • 1. 3-(DIMETHYLAMINO)PHENOL
  • Neostigmine bromide EP Impurity B
  • 99-07-0 3-Dimethylaminophenol
  • M-dimethylaminophenol/3-hydroxy-N, N-dimethylaniline
  • n,n-3-dimethylamino phenol
  • Neostigmine methylsulfate Intermediate 1
  • Neostigmine bromide Impurity B
  • Edrophonium Chloride EP Impurity A
  • 99-07-0
  • 90-07-0
  • 97-07-0
  • CH32NC6H4OH
  • ALCOHOL
  • Building Blocks
  • Oxygen Compounds
  • Phenols
  • Organic Building Blocks
  • Building Blocks
  • C6 to C8
  • Chemical Synthesis
  • Organic Building Blocks
  • Oxygen Compounds
  • Phenols
  • Phenoles and thiophenoles
  • Aromatic Phenols
  • benzene derivative
  • Amines
  • Aromatics