ChemicalBook > CAS DataBase List > 3-Hydroxy-2-methylbenzoic acid
3-Hydroxy-2-methylbenzoic acid
- Product Name
- 3-Hydroxy-2-methylbenzoic acid
- CAS No.
- 603-80-5
- Chemical Name
- 3-Hydroxy-2-methylbenzoic acid
- Synonyms
- HMBA;NSC 73133;3,2-Cresotic Acid;Hydroxytoluicacid,98%;3-HYDROXY-2-TOLUIC ACID;3-HYDROXY-O-TOLUIC ACID;2-Methyl-3-Hydroxybenzoic;3-Hydroxy-2-methylbenzoicaci;2-Methyl-3-hydroxybenzoicacid;3-HYDROXY-2-METHYLBENZOIC ACID
- CBNumber
- CB9179596
- Molecular Formula
- C8H8O3
- Formula Weight
- 152.15
- MOL File
- 603-80-5.mol
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3-Hydroxy-2-methylbenzoic acid Property
- Melting point:
- 143-148°C
- Boiling point:
- 336.6±30.0 °C(Predicted)
- Density
- 1.304±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 3.83±0.10(Predicted)
- color
- Light Yellow
- BRN
- 2613791
- InChI
- InChI=1S/C8H8O3/c1-5-6(8(10)11)3-2-4-7(5)9/h2-4,9H,1H3,(H,10,11)
- InChIKey
- RIERSGULWXEJKL-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC=CC(O)=C1C
- CAS DataBase Reference
- 603-80-5(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- PH005167
- Product name
- 3-hydroxy-2-methylbenzoic acid
- Purity
- AldrichCPR
- Packaging
- 5mg
- Price
- $172
- Updated
- 2023/06/20
TCI Chemical
- Product number
- H0885
- Product name
- 3-Hydroxy-2-methylbenzoic Acid
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $20
- Updated
- 2025/07/31
TCI Chemical
- Product number
- H0885
- Product name
- 3-Hydroxy-2-methylbenzoic Acid
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $41
- Updated
- 2025/07/31
TCI Chemical
- Product number
- H0885
- Product name
- 3-Hydroxy-2-methylbenzoic Acid
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $117
- Updated
- 2025/07/31
Usbiological
- Product number
- 278679
- Product name
- 3-Hydroxy-2-methylbenzoic acid
- Packaging
- 5g
- Price
- $305
- Updated
- 2021/12/16
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3-Hydroxy-2-methylbenzoic acid Chemical Properties,Usage,Production
Chemical Properties
Light Yellow Crystalline Solid
Uses
3-Hydroxy-2-methylbenzoic Acid (cas# 603-80-5) is a compound useful in organic synthesis.
Synthesis
52130-17-3
603-80-5
General procedure for the synthesis of 2-methyl-3-hydroxybenzoic acid from 3-amino-2-methylbenzoic acid: to 5 mL of water containing 0.65 mL of concentrated sulfuric acid, a cold (0°C) suspension of 0.54 g (3.3 mmol) of 2-methyl-3-aminobenzoic acid was added, followed by 0.25 g (3.6 mmol) of solid sodium nitrite. After about 15 minutes of reaction, the mixture was poured into 20 mL of warm water containing 4 mL of concentrated sulfuric acid. The reaction mixture was slowly heated to 90°C and gas was observed to escape. When gas release ceased, the solution was cooled to room temperature and extracted with ethyl acetate. The organic layers were combined, washed with 0.5 N hydrochloric acid, dried and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: 5% dichloromethane solution in methanol) to give 350 mg of white solid (melting point: 137-138°C) in 69% yield.1H NMR (CDCl3) data: δ 8.18 (br.s, 1H), 7.42 (d, J = 7.7 Hz, 1H), 7.13 (t, J = 7.9 Hz, 1H) , 6.93 (d, J = 7.9 Hz, 1H), 2.46 (s, 3H). Elemental analysis (C8H8O3) results: calculated values: C, 63.15; H, 5.29; measured values: C, 63.32; H, 5.36.
References
[1] Patent: US6335/459, 2002, B1. Location in patent: Page column 29
[2] Patent: US6335459, 2002, B1. Location in patent: Page column 29
[3] Tetrahedron Letters, 2000, vol. 41, # 11, p. 1741 - 1745
[4] Patent: US5952343, 1999, A
[5] Patent: US5484926, 1996, A
3-Hydroxy-2-methylbenzoic acid Preparation Products And Raw materials
Raw materials
Sodium nitrite
3-Amino-2-methylbenzoic acid
Ethyl acetate
Hydrochloric acid
Dichloromethane
Methanol
Sulfuric acid
Preparation Products
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View Lastest Price from 3-Hydroxy-2-methylbenzoic acid manufacturers
Shaanxi Dideu New Materials Co. Ltd
- Product
- 3-Hydroxy-2-methylbenzoic acid 603-80-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-12
Henan Aochuang Chemical Co.,Ltd.
- Product
- 3-Hydroxy-2-methylbenzoic acid 603-80-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-27
Hebei Yanxi Chemical Co., Ltd.
- Product
- 3-Hydroxy-2-methylbenzoic acid 603-80-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98.00%
- Supply Ability
- 20tons
- Release date
- 2023-09-12
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