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PD 166285

Product Name
PD 166285
CAS No.
212391-63-4
Chemical Name
PD 166285
Synonyms
PD 166285;PD 166285 dihydrochloride;PD0166285 dihydrochloride;PD 166285 ISO 9001：2015 REACH;PD 166285 - CAS 212391-63-4 - Calbiochem;6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimi;6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylaMino)ethoxy]phenyl]aMino]-8-Methylpyrido[2,3-d]pyriMidin-7(8H)-one;6-(2,6-dichlorophenyl)-2-[4-[2-(diethylamino)ethoxy]anilino]-8-methylpyrido[2,3-d]pyrimidin-7-one,dihydrochloride;6-(2,6-Dichloro-phenyl)-2-[4-(2-diethylaMino-ethoxy)-phenylaMino]-8-Methyl-8H-pyrido[2,3-d]pyriMidin-7-one hydrochloride;6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one Hydrochloride
CBNumber
CB91873310
Molecular Formula
C26H29Cl4N5O2
Formula Weight
585.37
MOL File
212391-63-4.mol
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PD 166285 Property

Melting point:
239-242?C
storage temp. 
Desiccate at RT
solubility 
DMSO, Methanol
form 
Pale yellow solid
color 
Yellow
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
513028
Product name
PD 166285 - CAS 212391-63-4 - Calbiochem<br />A cell-permeable, orally bioavailable, ATP-competitive, broad-spectrum tyrosine kinase inhibitor that suppresses angiogenesis both in vitro and in vivo.
Packaging
5mg
Price
$216
Updated
2024/03/01
Tocris
Product number
3785
Product name
PD166285dihydrochloride
Purity
≥99%(HPLC)
Packaging
1
Price
$118
Updated
2021/12/16
Usbiological
Product number
019157
Product name
PD-166285
Packaging
5mg
Price
$460
Updated
2021/12/16
Usbiological
Product number
286681
Product name
PD 166285
Packaging
2mg
Price
$460
Updated
2021/12/16
TRC
Product number
P217500
Product name
PD-166285
Packaging
25mg
Price
$565
Updated
2021/12/16
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PD 166285 Chemical Properties,Usage,Production

Chemical Properties

Yellow Solid

Uses

A broad-spectrum receptor tyrosine kinase (RTK) inhibitor which shows anti-angiogenic activity and anti-tumor efficacy in combination with photodynamic therapy (PDT).

General Description

A cell-permeable, orally bioavailable, ATP-competitive, broad-spectrum tyrosine kinase inhibitor (IC50 against against c-Src, Wee1, FGFR-1, Myt1, EGFR, and PDGFRβ = 8.4, 24, 39.3, 72, 87.5 and 98.3 nM, respectively) that suppresses angiogenesis both in vitro (max inhibition dose at 100 nM in HUVEC microcapillary formation assays) and in vivo (max inhibition achieved via 5 mg/kg p.o. in murine Matrigel plug angiogenesis assays), while exhibiting much reduced potency against Chk1, MAPK, and PKC (IC50 = 3.4, 5, and 22.7 μM, respectively) and little activity toward IRTK and Cdk4/D1 even at concentrations as high as 50 μM. Shown to effectively block PDGF-, EGF-, and bFGF-stimulated receptor phosphorylations (IC50 = 6.5, 1600, and 97.3 nM, respectively) and other cellular responses in rat aortic smooth muscle cells. Inhibition of cellular Wee1 activity by 500 nM PD 166285 in combination with 50 ng/ml nocodazole (Cat. No. 487928) treatment is also reported to result in a blockage of radiation-induced Cdc2 phosphorylation on Tyr15 and Thr14 in 7 human cancer cells and specifically demonstrated to sensatize PA-1 cultures to radiation-induced cell death in a p53-dependent manner.

Biological Activity

Potent inhibitor of the tyrosine kinases c-Src, fibroblast growth factor receptor 1 (FGFR1), and platelet-derived growth factor receptor β (PDGFR β ) (IC 50 values are 8.4, 39.3 and 98.3 nM respectively). Also inhibits the checkpoint kinases Wee1 and Myt1; abolishes Cdc2 phosphorylation in numerous tumor cell lines and abrogates the G 2 checkpoint.

storage

Desiccate at RT

PD 166285 Preparation Products And Raw materials

Raw materials

Preparation Products

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PD 166285 Suppliers

Canada 1 China 60 India 1 United Kingdom 1 United States 10 Global 73
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77
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View Lastest Price from PD 166285 manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
PD 166285 212391-63-4
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-04-30
Career Henan Chemical Co
Product
PD 166285 212391-63-4
Price
US $1.00/KG
Min. Order
1KG
Purity
97%-99.9%
Supply Ability
100kg
Release date
2019-12-26

212391-63-4, PD 166285Related Search:

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  • 6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one Hydrochloride
  • PD 166285
  • PD 166285 - CAS 212391-63-4 - Calbiochem
  • 6-(2,6-dichlorophenyl)-2-[4-[2-(diethylamino)ethoxy]anilino]-8-methylpyrido[2,3-d]pyrimidin-7-one,dihydrochloride
  • 6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-onedihydrochloride
  • PD 166285 dihydrochloride
  • 6-(2,6-Dichloro-phenyl)-2-[4-(2-diethylaMino-ethoxy)-phenylaMino]-8-Methyl-8H-pyrido[2,3-d]pyriMidin-7-one hydrochloride
  • 6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimi
  • 6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylaMino)ethoxy]phenyl]aMino]-8-Methylpyrido[2,3-d]pyriMidin-7(8H)-one
  • Pyrido[2,3-d]pyrimidin-7(8H)-one,6-(2,6-dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methyl-,hydrochloride(1:2)
  • PD 166285 ISO 9001：2015 REACH
  • PD0166285 dihydrochloride
  • 212391-63-4
  • C26H27Cl2N5O22HCl
  • C25H27Cl2N5O22HCl
  • C26H29Cl4N5O2
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Protein Kinase Inhibitors and Activators