1H-indazole-7-carboxylic acid

Product Name: 1H-indazole-7-carboxylic acid
CAS No.: 677304-69-7
Chemical Name: 1H-indazole-7-carboxylic acid
Synonyms: 7-Carboxy-1H-indazole;CgH6N2O2;Niraparib Intermediate4;7-INDAZOLE CARBOXYLIC ACID;7-INDAZOLE CARBOXYLLIC ACID;1H-Indazole-7-carboxylic aid;1H-Indazol-7-carboxylic acid;1H-INDAZOLE-7-CARBOXYLIC ACID;7-(1H)Indazole carboxylic acid;677304-69-7
CBNumber: CB9197275
Molecular Formula: C8H6N2O2
Formula Weight: 162.15
MOL File: 677304-69-7.mol

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1H-indazole-7-carboxylic acid Property

Melting point:: ca 240℃
Boiling point:: 443.7±18.0 °C(Predicted)
Density: 1.506±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Crystalline Powder
pka: 3.71±0.10(Predicted)
color: White to yellow

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Safety

HS Code: 29339980

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ANV00147
Product name: 1H-Indazole-7-carboxylic acid
Purity: AldrichCPR
Packaging: 1G
Price: $724
Updated: 2024/03/01

Alfa Aesar

Product number: H32463
Product name: 1H-Indazole-7-carboxylic acid, 95%
Packaging: 1g
Price: $405.65
Updated: 2024/03/01

Alfa Aesar

Product number: H32463
Product name: 1H-Indazole-7-carboxylic acid, 95%
Packaging: 250mg
Price: $164
Updated: 2023/06/20

TRC

Product number: H341003
Product name: 1H-indazole-7-carboxylicAcid
Packaging: 500mg
Price: $60
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: C11375
Product name: 1H-Indazole-7-carboxylicacid
Purity: 96%
Packaging: 1g
Price: $63
Updated: 2021/12/16

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1H-indazole-7-carboxylic acid Chemical Properties,Usage,Production

Uses

1H-indazole-7-carboxylic Acid is an inhibitor of nitric oxide synthases.

Preparation

Synthesis of 1H-indazole-7-carboxylic acid, H2L4: To 60 mL anhydrous toluene under a nitrogen atmosphere was added methyl-2-amino-3-methylbenzoate (1.8 g, 11 mmol) and KOAc (560 mg, 5.7 mmol), and the mixture heated to reflux, at which time acetic anhydride (3.2 mL, 34 mmol) was added and the mixture stirred at reflux for 10 min. Isoamyl nitrite (2.3 mL, 18 mmol) was added over 30 min and the mixture refluxed overnight. On cooling, the mixture was filtered and evaporated to dryness to give 1.6 g of a pale brown solid, which analysed for methyl 1H-indazole-7-carboxylate. This material was taken up in 40 mL THF, added to a solution of LiOH (5 g, 210 mmol) in 40 mL water, and heated at reflux for 48 h. On cooling, the mixture was concentrated on a rotary evaporator and the resulting aqueous phase filtered and adjusted to pH 4 with dilute HCl, to precipitate the product, which was filtered, washed with water and dried under vacuum. Yield 810 mg, 45%; mp 218–222 °C (decomp);
δH (500 MHz, d6-DMSO): 7.23 (t, 1H, J = 7.5 Hz, H4 ), 7.97 (dd, 1H, J = 7.5, 1.0 Hz, H3 ), 8.06 (dd, 1H, J = 7.8, 0.8 Hz, H5 ), 8.21 (s, 1H, H2 ), 13.1 (br s, 2H, H1 & H6 ); δc (125 MHz, d6-DMSO): 113.7, 120.1, 124.6, 126.5, 129.0, 134.3, 138.0, 167.0; HRMS-ESI m/z: found: 163.0503; C8H7N2O2 requires: 163.0502 [M + H+ ]; ˉνmax/cm?1 (KBr): 3316 s br, 1700 s, 1619 m, 1592 m, 1509 m, 1285 s, 1201 m, 1145 m, 1078 m, 1056 w, 943 m, 858 s, 745 s, 638 m, 601 m.

1H-indazole-7-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1H-indazole-7-carboxylic acid manufacturers

Nanjing Fred Technology Co., Ltd

Product: 1H-Indazole-7-carboxylic aid 677304-69-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-25

Shaanxi Dideu New Materials Co. Ltd

Product: 1H-indazole-7-carboxylic acid 677304-69-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2024-11-06

Hebei Weibang Biotechnology Co., Ltd

Product: 1H-indazole-7-carboxylic acid 677304-69-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-05

677304-69-7, 1H-indazole-7-carboxylic acidRelated Search:

1-[2,4-DICHLOROBENZYL]-1H-INDAZOLE-3-CARBOXYLIC ACID 1H-indazole-7-carboxylic acid 5-AMINO-1H-INDAZOLE-7-CARBOXYLIC ACID METHYL ESTER INDAZOLE-5-CARBOXYLIC ACID METHYL ESTER 1H-Indazole-3-carboxylic acid, 6-bromo- 5-Amino-1H-indazole-3-carboxylic acid methyl ester,1H-Indazole-3-carboxylic acid, 5-amino-, methyl ester Indazole 5-NITRO-1H-INDAZOLE-7-CARBOXYLIC ACID 3-FORMYL-7-INDAZOLE CARBOXYLIC ACID METHYL ESTER 5-AMINO-1H-INDAZOLE-7-CARBOXYLIC ACID 5-NITRO-1H-INDAZOLE-7-CARBOXYLIC ACID METHYL ESTER 6-AMINO-1H-INDAZOLE-7-CARBOXYLIC ACID 5-BROMO-7-INDAZOLECARBOXYLIC ACID METHYL ESTER 7-METHOXYCARBONYL-1H-INDAZOLE-3-CARBOXYLIC ACID 1H-INDAZOLE-7-CARBOXYLIC ACID ETHYL 1H-INDAZOLE-7-CARBOXYLATE 1-METHYL-1H-INDAZOLE-6-CARBOXYLIC ACID 7-ethyl-1H-indazole-3-carboxylic acid

7-INDAZOLE CARBOXYLLIC ACID

1H-INDAZOLE-7-CARBOXYLIC ACID

7-INDAZOLE CARBOXYLIC ACID

7-Carboxy-1H-indazole

7-(1H)Indazole carboxylic acid

1H-Indazol-7-carboxylic acid

Niraparib Intermediate4

CgH6N2O2

1H-Indazole-7-carboxylic aid

677304-69-7

Amines

C8

Chemical Synthesis

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Nitrogen Compounds

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Indazoles

Building Blocks

Indazole