ChemicalBook > CAS DataBase List > 3-Chloro-4-hydroxybenzaldehyde

3-Chloro-4-hydroxybenzaldehyde

Product Name
3-Chloro-4-hydroxybenzaldehyde
CAS No.
2420-16-8
Chemical Name
3-Chloro-4-hydroxybenzaldehyde
Synonyms
AKOS B028967;TIMTEC-BB SBB005887;TIMTEC-BB SBB004014;3-CHLORO-4-HYROXYBENZALDEHYDE;3-CHLORO-4-HYDROXYBENZALDEHYDE;Benzaldehyde, 3-chloro-4-hydroxy-;3-Chloro-4-hydroxybenzaldehyde >3-Chloro-4-hydroxybenzaldehyde 98%;3-Chloro-4-hydroxybenzaldehyde, 98%,;3-Chloro-4-hydroxybenzaldehyde, 99+%
CBNumber
CB9203815
Molecular Formula
C7H5ClO2
Formula Weight
156.57
MOL File
2420-16-8.mol
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3-Chloro-4-hydroxybenzaldehyde Property

Melting point:
133-137 °C (lit.)
Boiling point:
150 °C / 14mmHg
Density 
1.2683 (rough estimate)
refractive index 
1.5812 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
powder to crystal
pka
6.30±0.18(Predicted)
color 
White to Light yellow to Light orange
Sensitive 
Air Sensitive
InChI
InChI=1S/C7H5ClO2/c8-6-3-5(4-9)1-2-7(6)10/h1-4,10H
InChIKey
VGSOCYWCRMXQAB-UHFFFAOYSA-N
SMILES
C(=O)C1=CC=C(O)C(Cl)=C1
CAS DataBase Reference
2420-16-8(CAS DataBase Reference)
NIST Chemistry Reference
3-Chloro-4-hydroxybenzaldehyde(2420-16-8)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
36/37/38-43-41-37/38-22-20/21/22
Safety Statements 
26-37/39-36/37/39-36-37
WGK Germany 
3
Hazard Note 
Irritant/Air Sensitive
HS Code 
29130000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
644188
Product name
3-Chloro-4-hydroxybenzaldehyde
Purity
97%
Packaging
1g
Price
$34.2
Updated
2025/07/31
Sigma-Aldrich
Product number
644188
Product name
3-Chloro-4-hydroxybenzaldehyde
Purity
97%
Packaging
5g
Price
$142
Updated
2025/07/31
TCI Chemical
Product number
C2183
Product name
3-Chloro-4-hydroxybenzaldehyde
Purity
>97.0%(GC)(T)
Packaging
5g
Price
$334
Updated
2025/07/31
TCI Chemical
Product number
C2183
Product name
3-Chloro-4-hydroxybenzaldehyde
Purity
>97.0%(GC)(T)
Packaging
25g
Price
$1335
Updated
2025/07/31
TRC
Product number
C585768
Product name
3-Chloro-4-hydroxybenzaldehyde
Packaging
50mg
Price
$60
Updated
2021/12/16
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3-Chloro-4-hydroxybenzaldehyde Chemical Properties,Usage,Production

Chemical Properties

White solid

Synthesis

123-08-0

2420-16-8

The general procedure for the synthesis of 3-chloro-4-hydroxybenzaldehyde from 4-hydroxybenzaldehyde was as follows: N-chlorosuccinimide (1.1 g, 8.18 mmol) was added to a solution of 4-hydroxybenzaldehyde (1.0 g, 8.18 mmol) dissolved in 10 ml of chloroform. The reaction mixture was heated and stirred at 50°C for 15 hours. After completion of the reaction, it was cooled to room temperature and concentrated under reduced pressure to remove the solvent. The residue was dissolved in 25 ml of ethyl acetate, washed sequentially with water and saturated saline, and the organic phase was dried with anhydrous sodium sulfate. After filtration, the crude product was obtained by concentration under reduced pressure. The crude product was purified by silica gel column chromatography using 12% ethyl acetate in hexane solution as eluent to give 1.1 g (86% yield) of 3-chloro-4-hydroxybenzaldehyde.1H-NMR (400 MHz, CDCl3) δ (ppm): 9.840 (s, 1H), 7.898-7.894 (d, 1H, J = 1.6 Hz), 7.749- 7.724 (dd, 1H, J = 8.4Hz), 7.164-7.143 (d, 1H, J = 8.4Hz), 6.288 (s, 1H).

References

[1] Tetrahedron Letters, 1994, vol. 35, # 28, p. 5043 - 5046
[2] Patent: WO2010/127212, 2010, A1. Location in patent: Page/Page column 35
[3] Patent: WO2010/127208, 2010, A1. Location in patent: Page/Page column 55
[4] Tetrahedron Asymmetry, 1997, vol. 8, # 24, p. 4003 - 4006
[5] Synthetic Communications, 2012, vol. 42, # 24, p. 3655 - 3663,9

3-Chloro-4-hydroxybenzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Chloro-4-hydroxybenzaldehyde Suppliers

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View Lastest Price from 3-Chloro-4-hydroxybenzaldehyde manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
3-Chloro-4-hydroxybenzaldehyde 2420-16-8
Price
US $0.00-0.00/KG
Min. Order
10mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-15
Career Henan Chemical Co
Product
3-Chloro-4-hydroxybenzaldehyde 2420-16-8
Price
US $1.00/KG
Min. Order
1KG
Purity
95%-99%
Supply Ability
100KG
Release date
2019-08-29

2420-16-8, 3-Chloro-4-hydroxybenzaldehydeRelated Search:

3-Hydroxybenzaldehyde 3-CHLORO-4-HYDROXYBENZOIC ACID Protocatechuic acid Salicylaldehyde 4-Hydroxybenzaldehyde 2-Chloro-3-hydroxypyridine Benzaldehyde Difluorochloromethane Ethacrynic acid 5-CHLOROVANILLIC ACID METHYL 3,5-DICHLORO-4-HYDROXYBENZOATE METHYL 3-CHLORO-4-HYDROXYBENZOATE 3,5-Dichloro-4-hydroxybenzoic acid 3-CHLORO-4-METHOXYBENZALDEHYDE METHYL 3-CHLORO-4-METHOXYBENZOATE 3-CHLORO-4-METHOXYBENZOIC ACID ETHYL 3,5-DICHLORO-4-HYDROXYBENZOATE 5-Chlorosalicylaldehyde

  • Benzaldehyde, 3-chloro-4-hydroxy-
  • TIMTEC-BB SBB004014
  • TIMTEC-BB SBB005887
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