(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine

Product Name: (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine
CAS No.: 132335-44-5
Chemical Name: (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine
Synonyms: (s)-3-(dimethylamino)-1-(2-thienyl)-1-propanol;(S)-3-(Dimethylamino)-1-(2-thienyl)propan-1-ol;(S)-3-(dimethylamino)-1-(thiophen-2-yl)propan-1-ol;Duloxetine-18;Duloxetine Impurity49;Duloxetine intermediate AA;InterMediate of Duloxetine;Duloxetine Hydroxy IMpurity;Duloxetine S-Hydroxy Impurity;S-(-)-N,N-Dimethyl-3-hydroxy-3
CBNumber: CB9204180
Molecular Formula: C9H15NOS
Formula Weight: 185.29
MOL File: 132335-44-5.mol

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(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine Property

Melting point:: 78-80°C
Boiling point:: 290°C
Density: 1.111
Flash point:: 129°C
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 13.74±0.20(Predicted)
form: Solid
color: White
InChI: InChI=1/C9H15NOS/c1-10(2)6-5-8(11)9-4-3-7-12-9/h3-4,7-8,11H,5-6H2,1-2H3/t8-/s3
InChIKey: XWCNSHMHUZCRLN-SBYBRXNCNA-N
SMILES: C(N(C)C)C[C@H](O)C1SC=CC=1 |&1:5,r|
CAS DataBase Reference: 132335-44-5(CAS DataBase Reference)

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D4010
Product name: (S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $22
Updated: 2025/07/31

TCI Chemical

Product number: D4010
Product name: (S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $62
Updated: 2025/07/31

TRC

Product number: H961825
Product name: (S)-1-β-Hydroxy-1-(2-thienyl)-3-dimethylaminopropane
Packaging: 1g
Price: $50
Updated: 2021/12/16

Activate Scientific

Product number: AS34101
Product name: (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine
Purity: 98+% ee
Packaging: 5G
Price: $16
Updated: 2021/12/16

Activate Scientific

Product number: AS34101
Product name: (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine
Purity: 98+% ee
Packaging: 1g
Price: $18
Updated: 2021/12/16

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(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

A Duloxetine intermediate.

Synthesis

13196-35-5

132335-44-5

General procedure for the synthesis of (S)-N,N-dimethyl-3-hydroxy-3-(2-thienyl)propylamine from N/A (Example 23): under argon protection, (R,R)-Cl2((R)-hexylBINAP)((R)-DAIPEN) (30.5 mg, 0.025 mmol), 2-propanol (100 ml), 1.0 M tert-butyl potassium oxychloride solution of 2-propanol (7.5 ml, 7.5 mmol) and 3-(N,N-dimethylamino)-1-(2-thienyl)-1-propanone (22.9 g, 0.125 mol) were added sequentially to a glass autoclave. After the reaction system was degassed several times and replaced with argon, hydrogen was introduced to a predetermined pressure to start the reaction. After stirring the reaction at 28°C for 6 hours, the reaction system was returned to normal temperature and pressure. The reaction solution was concentrated, heptane was added and the precipitated solid was filtered. The resulting solid was dried under reduced pressure to afford (S)-N,N-dimethyl-3-hydroxy-3-(2-thienyl)propylamine 18.5 g in 80.0% yield. The optical purity of the product was determined by chiral column HPLC, and the result showed that the optical purity was 99% ee. Note: (R)-DAIPEN is (R)-1-isopropyl-2,2-bis(p-methoxyphenyl)ethylenediamine, and xylBINAP is 2,2'-bis(bis-3,5-dimethylphosphinodiphenyl)-1,1'-binaphthyl.

References

[1] Patent: EP1506965, 2005, A1. Location in patent: Page/Page column 35
[2] Angewandte Chemie (International ed. in English), 2004, vol. 43, # 21, p. 2816 - 2819
[3] Chemistry - A European Journal, 2011, vol. 17, # 28, p. 7760 - 7763
[4] Patent: US8426178, 2013, B2. Location in patent: Page/Page column
[5] Chemical Communications, 2015, vol. 51, # 61, p. 12328 - 12331

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine Suppliers

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View Lastest Price from (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine 132335-44-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-18

Hebei Dangtong Import and export Co LTD

Product: 132335-44-5 132335-44-5
Price: US $55.00-50.00/kg
Min. Order: 10kg
Purity: 99.99%
Supply Ability: 100Tons
Release date: 2023-03-03

Henan Bao Enluo International TradeCo.，LTD

Product: (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine 132335-44-5
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000tons
Release date: 2023-07-04

132335-44-5, (S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamineRelated Search:

Dimethyl disulfide ETHANE Dimethyl sulfoxide 3-Dimethylaminopropylamine Diisopropylamine Dimethyl sulfate Dimethyl ether Dimethyl carbonate Isopropylamine Tetrahydrothiophene Dimethyl fumarate 1-Propanol Cephalothin sodium Dacthal N,N-Dimethylformamide D/L-AMPHETAMINE HYDROCHLORIDE 3-(Dimethylamino)-1-(2-thienyl)-1-propanol (-)-2-[METHYLAMINO]-1-PHENYLPROPANE

(S)-1-HYDROXY-1-(2-THIENYL)-3-DIMETHYLAMINOPROPANE

(S)-1-BETA-HYDROXY-1-(2-THIENYL)-3-DIMETHYLAMINOPROPANE

(s)-3-(dimethylamino)-1-(2-thienyl)-1-propanol

(S)-(-)-N-DIMETHYL-3-HYDROXY-3-(2-THIENYL)-PROPANAMINE

S-(-)-N,N-DIMETHYL-3-HYDROXY-3-(2-THIENYL)PROPANAMINE

(S)-N,N-dimethyl-3-hydroxy-3-(2-thienyl)-2-propanamine

Duloxetine intermediate AA

(S)-(-)-N,N-dimethyl-3-hydroxy-3-(2-thienyl)propylamine

(S)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)-1-propylamine

S-(-)-N,N-Dimethyl-3-hydroxy-3

S-(-)-N,N-DIME-3-HY-3-(2-THIENYL)1PROPAMINE

(S)-3-(dimethylamino)-1-(thiophen-2-yl)propan-1-ol

S-(-)-N,N-Dime-3-Hy-3-(2-Thienyl)propamine

(1S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol

S-(-)-N,N-Dimethyl-3-hydroxy-(2-thienol)propanamine

(S)-(-)-N,N-DiMethyl-3-hydroxy-3-(2-thienyl)propan

(S)-N,N-DiMethyl-3-(2-thienyl)-3-hydroxypropanaMine

(S)-2-[3-(Dimethylamino)-1-hydroxypropyl]thiophene

InterMediate of Duloxetine

(S)-(-)-N,N-diMethyl-3-hydroxy-3-(2-thienyl)

Duloxetine Hydroxy IMpurity

(S)-(-)-alpha-methyl-1-naphthalenemethhanol

(<i>S</i>)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol

2-Thiophenemethanol, a-[2-(dimethylamino)ethyl]-, (aS)-

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propamine

(S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol,99%e.e.

Duloxetine S-Hydroxy Impurity

S-(-)-N, N-dimethyl-3-hydroxy-3- (2-thiophene) propylamine

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine in stock Factory

DUG-4 (S)-(-)-N,N-Dimethyl-3-Hydroxy-3-(2-Thienyl) Propanamine

Duloxetine-18

(1S)-3-(dimethylamino)-1-(thiophen-2-yl)propan-1-ol

(S)-3-(Dimethylamino)-1-(2-thienyl)propan-1-ol

(S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol&gt

(S)-3-dimethylamino-1-(2-thiophene)-1-propanol

Duloxetine Dimethylaminopropanol Impurity

2-Thiophenemethanol, α-[2-(dimethylamino)ethyl]-, (αS)-

(S)-(-)N, N-dimethyl-3-hydroxy 3-(2-thieyl)propanamine

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine(For export only)

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine ISO 9001：2015 REACH

(S)-1-β-Hydroxy-1-(2-thienyl)-3-dimethylaminopropane

S-(-)-N,N-dimethtl-3-hydroxy-3-(2-thienyl)propanamine

Duloxetine Dimethylaminopropanol Impurity/ Duloxetine Hydroxy Impurity

Duloxetine Impurity49

(S)-N,N-Dimethyl-3-(thiophen-2-yl)-3-hydroxy-propanamine

(s)-3-(dimethylamino)-1-(thiophen-2-yl)propan-1-Ol /mandelate salt

(S)-3-(Dimethylamino)-1-(2-thienyl)-1-propanol(DMTP)

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propana

(S)-(-)-3-(dimethylamino)-1-(2-thienyl)-1-propanol mandalate salt

(1S)-3-(dimethylamino)-1-(2-thienyl)propan-1-ol

N,N diethyl-3- hydroxy-3-(2- thienyl)- propanamine,Duloxetine Hydrochloride

(S)-(-)-N,N-Dimethyl-3-hydroxy-3-(thiophen-2-yl)-propanamine

132335-44-5

1323235-44-5

C9H15NOS2

C9H15NOS

Heterocycles

Intermediates & Fine Chemicals