ChemicalBook > CAS DataBase List > Tricaine methanesulfonate

Tricaine methanesulfonate

Product Name: Tricaine methanesulfonate
CAS No.: 886-86-2
Chemical Name: Tricaine methanesulfonate
Synonyms: MS-222;TRICAINE;ETHYL 3-AMINOBENZOATE METHANESULFONATE;MS-22;TS 222;TRICAIN;finquel;metacaine;MS-222, Tricaine;MS-22、MS-222、TRICAIN
CBNumber: CB9214426
Molecular Formula: C9H11NO2.CH4O3S
Formula Weight: 261.3
MOL File: 886-86-2.mol

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Tricaine methanesulfonate Property

Melting point:: 146-149 °C(lit.)
Density: 1.3799 (rough estimate)
refractive index: 1.5060 (estimate)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: H₂O: 50 mg/mL, clear, colorless
form: Fine Powder
color: White to off-white
Merck: 14,9621
BRN: 3775022
InChI: InChI=1S/C9H11NO2.CH4O3S/c1-2-12-9(11)7-4-3-5-8(10)6-7;1-5(2,3)4/h3-6H,2,10H2,1H3;1H3,(H,2,3,4)
InChIKey: FQZJYWMRQDKBQN-UHFFFAOYSA-N
SMILES: C1(C=CC=C(N)C=1)C(=O)OCC.S(=O)(=O)(O)C
CAS DataBase Reference: 886-86-2(CAS DataBase Reference)
EPA Substance Registry System: Benzoic acid, 3-amino-, ethyl ester, methanesulfonate (886-86-2)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: DG2455000
F: 10
HS Code: 29224999
Toxicity: LC50 (96hr) in rainbow trout: 50.50 mg/l (McKim)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A5040
Product name: Ethyl 3-aminobenzoate methanesulfonate salt
Purity: analytical standard
Packaging: 25g
Price: $123
Updated: 2025/07/31

Sigma-Aldrich

Product number: A5040
Product name: Ethyl 3-aminobenzoate methanesulfonate salt
Purity: analytical standard
Packaging: 100g
Price: $327
Updated: 2025/07/31

TCI Chemical

Product number: T0941
Product name: Tricaine
Purity: >97.0%(HPLC)(N)
Packaging: 25g
Price: $82
Updated: 2025/07/31

Cayman Chemical

Product number: 20660
Product name: Ethyl 3-Aminobenzoate (methanesulfonate)
Purity: ≥98%
Packaging: 10g
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 20660
Product name: Ethyl 3-Aminobenzoate (methanesulfonate)
Purity: ≥98%
Packaging: 25g
Price: $75
Updated: 2024/03/01

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Tricaine methanesulfonate Chemical Properties,Usage,Production

Chemical Properties

WHITE TO OFF-WHITE FINE POWDER

Uses

A benzocaine isomer derivative.

Uses

The anesthetic of choice for amphibians is tricaine methanesulfonate (MS - 222, tricaine, FINQUEL, Argent Chemical Laboratories, Redmond, WA) (Wright 2001f ). It is a white crystalline powder that may be mixed with water to anesthetize fi sh and amphibians. Amphibians are immersed in a bath of tricaine methanesulfonate until anesthesia is achieved and then maintained in fresh water for the particular procedure to be performed. For longer procedures, the patient may be immersed in a 50% dilution of the original induction solution or intubated and maintained on isofl urane.

Uses

Ethyl 3-Aminobenzoate Methanesulfonate is used as anesthetic for broodfish such as rainbow trout and red pacu. Ethyl 3-Aminobenzoate Methanesulfonate also acts as the sodium channel blocker which reverses the degenerative effects of fipronil insecticide.

Definition

ChEBI: A methanesulfonate salt obtained by reaction of tricaine with one molar equivalent of methanesulfonic acid. Used as an anaesthetic for fish.

General Description

Ethyl 3-aminobenzoate methanesulfonate is mainly used as an anesthetic for fish. It is also used for the euthanasia of all fish species especially zebrafish, which is commonly used in research.

Biological Activity

ethyl 3-aminobenzoate can block the generation of action potentials via voltage-dependent na+-channels.sodium channels play a critical role in physiology: they can rapidly transmit depolarizing impulses throughout cells and cell networks, therefore enabling co-ordination of higher processes. sodium channels are also of special importance for the history of physiology.

in vitro

the major mode of action for ethyl 3-aminobenzoate was found to be nervous system suppression whereby the entrance of sodium into the nerve was inhibited, therefore limiting nerve membrane excitability. in addition, the nerve inhibition was facilitated by the lipid solubility of ethyl 3-aminobenzoate, which allowed it to move easily into the cell membrane to bind with sodium channels [1].

in vivo

previous study evaluated the potency and dynamics of ethyl 3-aminobenzoate-induced effects on neuronal firing of sensory and motor nerves alongside a defined motor behavior in xenopus laevis tadpoles. electrophysiological recordings of extraocular motor discharge and nerve activity were measured before, during and after administration of drugs. results showed that ethyl 3-aminobenzoate and benzocaine, but not pancuronium could cause a dose-dependent, reversible blockade of extraocular motor and sensory nerve activity. such results indicated that ethyl 3-aminobenzoate was able to block the activity of both sensory and motor nerves compatible with the mechanistic action of effective anesthetics, suggesting that ethyl 3-aminobenzoate was effective as single-drug anesthetic for surgical interventions in anamniotes [2].

References

[1] k. m. carter, c. m. woodley and r. s. brown. a review of tricaine methanesulfonate for anesthesia of fish. rev. fish biol. fisheries 21, 51-59 (2011).
[2] c. ramlochansingh, f. branoner, b. p. chagnaud, et al. efficacy of tricaine methanesulfonate (ms-222) as an anesthetic agent for blocking sensory-motor responses in xenopus laevis tadpoles. plos one 9(7), e101606 (2014).

Tricaine methanesulfonate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Tricaine methanesulfonate manufacturers

HANGZHOU HAILAN CHEMICAL CO.,LTD.

Product: Tricaine methanesulfonate 886-86-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20tons
Release date: 2025-09-19

Henan Aochuang Chemical Co.,Ltd.

Product: Tricaine methanesulfonate 886-86-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-14

Shanghai Biolang Biotechnology Co., Ltd.

Product: Tricaine methanesulfonate 886-86-2
Price: US $99.99-77.77/g
Min. Order: 10g
Purity: 99.99%HPLC.USP42——Powder、Oil、Pills、Capsules、Tablets，Customiz
Supply Ability: 1000kgs
Release date: 2022-02-23

886-86-2, Tricaine methanesulfonateRelated Search:

Ethyl acetate ETHYL ANTHRANILATE Triethyl orthoformate Methanesulfonic acid Ethylbenzene Ethyl acrylate Ethyl benzoate Cyclohexanecarboxylic acid ethyl ester Ethyl cellulose Ethylparaben Ethanol Ethyl formate Urethane Ethyl methanesulfonate Benzyl 3-Aminopropionate Hydrochloride Ethyl chloroformate METHANE Diethyl ether

MS-22

MS-222

TRICAIN

TRICAINE

TRICAINE METHANESULFONATE

TRICAINE METHANSULFONATE

benzoicacid,3-amino-,ethylester,methanesulfonate

finquel

metacaine

Ethyl 3-aminobenzoate, methanesulfonic acid salt,98%

Ethyl 3-aMinobenzoate, Methanesulfonic acid salt, 98% 10GR

3-Aminobenzoic Acid Ethyl Ester Methanesulfonate Ethyl 3-Aminobenzoate Methanesulfonate

M-AMino benzoic acid ethyl ester Methanesulfonate

Uthyl meta-aminobenzoate, methanesulfonic acid salt, 98%

AMinobenzoic acid ethyl ester-Methanesulfonate pure

Ethyl 3-aMinobenzoate Methanesulfonate 98%

TS 222

ethyle3-aminobenzoate, methanesulfonic acid salt

MS-22、MS-222、TRICAIN

ethyl 3-aminobenzoate,methanesulfonic acid

3-AMINOBENZOIC ACID ETHYL ESTER METHANESULFONATE

3-AMINOBENZOIC ACID ETHYL ESTER METHANESULFONATE SALT

3-AMINOBENZOIC ACID ETHYL ESTER METHANESULFONIC SALT

3-Ethoxycarbonylanilinium methanesulphonate

M-AMINOBENZOIC ACID ETHYL ESTER METHANESULFONATE SALT

ETHYL M-AMINOBENZOATE METHANESULFONATE

ETHYL M-AMINOBENZOATE METHANESULFONATE SALT

ETHYL M-AMINOBENZOATE METHANESULFONIC ACID SALT

ETHYL 3-AMINOBENZOATE METHANESULFONATE

ETHYL 3-AMINOBENZOATE, METHANESULFONIC ACID SALT

Aminobenzoic acid ethyl ester-methanesulfonate

ethyl 3-aminobenzoate methanesulfonate salt

ETHYL3-AMINIBENZOATEMETHANESULFONICACIDSALT

TRICAINEMETHANESULPHONATE

METHANESULPHONATEOFMETA-AMINOBENZOICACIDETHYLESTER

3-AMINOBENZOICACIDETHYLESTERMETHANESULPHONATE

Ethyl 3-aminobenzoate methanesulphonate salt

Tricaine methansulphate

MS-222, Tricaine

Ethyl 3-aminobenzoate methanesulphonic acid

ETHYL 3-AMINOBENZOATE, METHANESULFONIC A

MS-222, Tricaine methanesulfonate, Tricaine

Ethyl 3-Aminobenzoate Methanesulfonate,>98%

Tricaine methanesulfonate ISO 9001：2015 REACH

fish population stability

Benzocaine Impurity C as Methanesulfonate

Benzocaine EP Impurity C as Methanesulfonate

Tricaine methanesulfonate-D5

C17669050 TricainEMethanesulfonate

Tricaine methanesulfonate, 10 mM in DMSO

886-86-2

C10H15NSO5

C9H11NO2xCH4O3S

H2NC6H4CO2C2H5CH3SO3H

C9H11NO2CH4O3S

C10H15NO5S

C9H11NO2CH4SO3

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