Nilvadipine

Product Name: Nilvadipine
CAS No.: 75530-68-6
Chemical Name: Nilvadipine
Synonyms: ESCOR;SKF-;fk235;ARC029;Nivadip;Nivadil;FR-34235;CL 287389;BAY-e-6927;SKF-102362
CBNumber: CB9223154
Molecular Formula: C19H19N3O6
Formula Weight: 385.37
MOL File: 75530-68-6.mol

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Nilvadipine Property

Melting point:: 148-150°C
Boiling point:: 511.83°C (rough estimate)
Density: 1.3937 (rough estimate)
refractive index: 1.5900 (estimate)
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: DMSO: soluble15mg/mL, clear
form: powder
pka: -0.81±0.70(Predicted)
color: white to beige
Merck: 14,6545
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3
RTECS: US7968300
HS Code: 2933.39.9200
Toxicity: LD50 oral in rat: 1560mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0945
Product name: Nilvadipine
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $58.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0945
Product name: Nilvadipine
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $163
Updated: 2024/03/01

TCI Chemical

Product number: N0899
Product name: Nilvadipine
Purity: >95.0%(N)
Packaging: 1g
Price: $108
Updated: 2024/03/01

TCI Chemical

Product number: N0899
Product name: Nilvadipine
Purity: >95.0%(N)
Packaging: 5g
Price: $322
Updated: 2024/03/01

Cayman Chemical

Product number: 21243
Product name: Nilvadipine
Purity: ≥98%
Packaging: 5mg
Price: $32
Updated: 2024/03/01

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Nilvadipine Chemical Properties,Usage,Production

Description

Nilvadipine is a new, second-generation calcium channel blocker effective in the treatment of hypertension and angina pectoris. Its potent inhibitory effect on the stimulated chemotaxis of smooth muscle cells and protective action against calcium deposition suggest that nilvadipine may be useful for preventing and treating atherosclerosis.

Chemical Properties

Yellow Prisms

Originator

Fujisawa (Japan)

Uses

Used as an antihypertensive and antianginal.

Uses

antihypertensive;calcium channel blocker

Definition

ChEBI: Nilvadipine is an isopropyl ester, a methyl ester, a nitrile and a dihydropyridine.

Manufacturing Process

To a solution of isopropyl ester of 6-formyl-5-methoxycarbonyl-2-methyl-4-(3- nitrophenyl)-1,4-dihydropyridine- 3-carboxylic acid (4.5 g) in acetic acid (35 ml) were added hydroxylamine hydrochloride (0.97 g) and sodium acetate (1.43 g), and the mixture was stirred at ambient temperature for 2.5 hours. After acetic anhydride (4.14 g) was added to this reaction mixture, the mixture was stirred at ambient temperature for 1.5 hours and at 95-100°C for additional 4 hours. The acetic acid and the excess of acetic anhydride were removed in vacuum, followed by adding water to the residue and it was neutralized with a saturated aqueous solution of sodium bicarbonate. This aqueous suspension was extracted twice with ethyl acetate, and the combined extract was washed with water, dried over anhydrous magnesium sulfate and evaporated to dryness under reduced pressure to give a reddish-brown oil (4.88 g), which was chromatographed over silica gel (150 g) with a mixture of benzene and ethyl acetate (10:1 by volume) as an eluent to give a crude crystals (2.99 g). These were recrystallized from ethanol to give yellow prisms (1.89 g) of isopropyl ester of 6-cyano-5-methoxycarbonyl-2-methyl-4-(3- nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid melting point 148-150°C (yellow prisms from ethanol); [α]D20 = 222.4° (c = 1 in methanol).

brand name

Nivadil

Therapeutic Function

Calcium entry blocker, Antihypertensive

References

1) Paris?et al. (2014),?The spleen tyrosine kinase (Syk) regulates Alzheimer amyloid-β production and Tau hyperphosphorylation; J. Biol. Chem.,?289?33927 2) Rosenthal (1994),?Nilvadipine: profile of a new calcium antagonist. An overview; J. Cardiovasc. Pharmacol. 24 Suppl 2?S92 3) Nimmrich and Eckert (2013),?Calcium channel blockers and dementia; Br. J. Pharmacol.?169?1203 4) Otori?et al. (2003),?Protective effect of nilvadipine against glutamate neurotoxicity in purified retinal ganglion cells; Brain Res.?961?213

Nilvadipine Preparation Products And Raw materials

Raw materials

Erythromycin Estolate Methyl 4,4-dimethoxyacetylacetate (2-METHYL-1H-INDOL-3-YL)-OXO-ACETIC ACID ETHYL ESTER Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Hydroxylamine hydrochloride Crotonic acid

Preparation Products

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Nilvadipine Suppliers

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View Lastest Price from Nilvadipine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Nilvadipine 75530-68-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-11

Career Henan Chemical Co

Product: Nilvadipine 75530-68-6
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000KG
Release date: 2018-08-21

Hebei Jiangkai Trading Co., Ltd

Product: Nilvadipine;;fk235;SKF-102362 75530-68-6
Price: US $3.00/KG
Min. Order: 1G
Purity: 98.67% ada@tuskwei.com sky;17197824028whapp;+00867197824028
Supply Ability: 6000g/day
Release date: 2018-01-29

75530-68-6, NilvadipineRelated Search:

ISOPROPYL LAURATE Methylparaben Tribenuron methyl Isopropyl acetate Isopropyl alcohol Dihydromyrcenol Propyl acetate Methanol Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Propyl gallate Nisoldipine Nitrendipine Methyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Methyl Ester M-NIFEDIPINE Nilvadipine (R)-(+)-Nilvadipine,(R)-Nilvadipine (S)-(-)-Nilvadipine,(S)-Nilvadipine

2-cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-5-pyridinedicarboxylicacid

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-isopropyl 5-methyl ester

BAY-e-6927

2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-isopropyl ester

2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid O5-isopropyl ester O3-methyl ester

3-O-methyl 5-O-propan-2-yl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

O3-methyl O5-propan-2-yl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 5-Isopropyl 3-Methyl Ester 5-Isopropyl 3-Methyl 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

Nilvadipine (ARC029)

Nivadip

3,5-Pyridinedicarboxylicacid, 2-cyano-1,4-dihydro-6-Methyl-4-(3-nitrophenyl)-, 3-Methyl5-(1-Methylethyl) ester

5-isopropyl 3-methyl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

ARC029

5-Isopropyl-3-methyl-2-cyano-1,4-dihydro-6-methyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate

Isopropyl 6-cyano-5-methoxycarbonyl-2-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate

SKF-

Nilvadipine-d4

Nilvadipine, >=99%

3-methyl-5-(1-methylethyl)ester

fk235

SKF-102362

NILVADIPINE

2-CYANO-1,4-DIHYDRO-6-METHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID 3-METHYL 5-(1-METHYLETHYL) ESTER

5-isopropyl-3-methyl 2-cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate

Isopropyl-6-formyl-5-methoxycarbonyl-2-methyl-4-(3-nitrophenyl)-1,4- dihydropyridine-3-carboxylate

FR-34235

ESCOR

Nilvaldipine

2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Methyl 5-(1-Methylethyl) Ester, FR-34235, SKF-102362, Escor,

3,5-Pyridinedicarboxylic acid, 2-cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-, 3-methyl 5-(1-methylethyl) ester (9CI)

CL 287389

dl-Nilvadipine

Nivadil

Escor：Nivadil

Nivadipine

Nivaldipine

Nilvadipine Impurity

FK235;ESCOR;FR34235;NIVADIL;NIVADIP

2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid O3-methyl ester O5-propan-2-yl ester

Nilvadipine&gt

Nilvadipine RS

2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 5-Isopropyl 3-Methyl Ester

Nilvadipine USP/EP/BP

Nilvadipine, ≥ 95.0%

75530-68-6

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